On the white matter lesions of the Creutzfeldt-Jakob disease. Can a new subentity be recognized in man?
J Neurol Sci
; 63(2): 197-206, 1984 Feb.
Article
em En
| MEDLINE
| ID: mdl-6368755
ABSTRACT
One case of CJD with severe involvement of the white matter is discussed. The patient was admitted after a 3-month clinical course with rapidly increasing mental deterioration, coma vigil-like state, myoclonic twitching of the limbs and of the facial muscles. The EEG showed the typical features of CJD. The first CT scan, performed 3 months after onset, revealed only a mild cortical and subcortical atrophy of the brain. The second CT scan, 12 months later, showed a considerable cortical and subcortical atrophy of the brain. The patient died 18 months after onset. Neuropathological examination showed a severe degeneration in the gray matter, with spongiosis, loss of neurones and hypertrophic glial reaction. The white matter was also involved with severe spongiosis, demyelination and hypertrophic glial proliferation. The case is discussed in relation to the data in the literature. It is argued that cases of CJD with severe involvement of the white matter should be classified as a new neuropathological subentity of CJD.
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Bases de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Síndrome de Creutzfeldt-Jakob
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
1984
Tipo de documento:
Article