The minimal amino acid sequence of the insulin-potentiating fragments of human growth hormone: its mechanism of action.
Diabetes
; 29(10): 782-7, 1980 Oct.
Article
em En
| MEDLINE
| ID: mdl-6777219
ABSTRACT
A series of synthetic peptides corresponding to the amino-terminal sequence of human growth hormone (hGH) has been studied for insulin-potentiating effects using three different bioassay systems (1) intravenous insulin tolerance tests, (2) insulin binding to specific receptors of hepatic plasma membranes and isolated hepatocytes, and (3) modulation of insulin-dependent glycogen synthase and glycogen phosphorylase in muscle and adipose tissue. The results establish that the minimum active sequence is the hexapeptide (hGH 8-13) containing H2N-Arg-Leu-Phe-Asp-Asn-Ala-COOH and strongly indicate that the insulin-potentiating action of the active peptides is to increase the binding of insulin to specific receptors and thus modulate the action of glycogen synthase and phosphorylase, producing hypoglycemia as the result of increased glycogen storage in liver, muscle, and adipose tissue.
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Bases de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Hormônio do Crescimento
/
Insulina
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Diabetes
Ano de publicação:
1980
Tipo de documento:
Article