Hypertension produced by sodium depletion and unilateral nephrectomy: a new experimental model.
Hypertension
; 2(2): 125-9, 1980.
Article
em En
| MEDLINE
| ID: mdl-6991408
Unilateral nephrectomy of sodium-restricted male Sprague-Dawley rats produced a sustained elevation in systolic blood pressure (SBP) that was reversed by sodium repletion. A chronic intraperitoneal infuson of SQ14,225 prevented the development of hypertension in sodium-deplete unilaterally nephrectomized rats. Sodium depletion of two-kidney rats increased SBP to a lesser extent, while unilateral nephrectomy of sodium replete animals had no effect. These results provide evidence for a new model of experimental hypertension in the rat and emphasize the importance of a renal component, as demonstrated by unilateral nephrectomy, in the maintenance of normal pressure-volume relationships.
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Bases de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
/
Hipertensão
Limite:
Animals
Idioma:
En
Revista:
Hypertension
Ano de publicação:
1980
Tipo de documento:
Article