[Studies into human foetal pancreas--critical appraisal of methods for tissue preparation (author's transl)]. / Untersuchungen am humanen fetalen Prankreas--Methodenkritik zur Gewebegewinnung.

ABSTRACT

Three different methods of legal abortion were applied to 23 patients, who had asked for termination of pregnancy, between the eleventh and 14th weeks of pregnancy. In vitro studies into human foetal pancreas were taken into consideration, when the choice was made. Carbohydrate tolerance was normal in all cases (50 g oGTT). Timing of intra-uterine foetal death, in the context of the three above methods (B-scan ultrasonic diagnosis and HPL level measurement) as well as studies into in vitro stimulation of foetopancreatic insulin secretion have shown purely mechanical, surgical abortion, sometimes following prostaglandin cervical gel priming, to be indispensable a condition for successful in vitro elucidation of the aetiopathogenesis of foetal diabetes. Extra-amniotic prostaglandin induction of abortion has failed to yield any relevant information, in that context.

ABSTRACT

PIP 3 different methods of legal abortion were administered to 23 patients who had requested termination of pregnancy between weeks 11-14 of pregnancy. In vitro studies into human fetal pancreas were taken into consideration when the choice was made. Carbohydrate tolerance was normal in all cases (50 g oGTT). Timing of intrauterine fetal death, in the context of the 3 above methods (B-scan ultrasonic diagnosis and HPL level measurement), as well as studies into in vitro stimulation of fetopancreatic insulin secretion, have shown purely mechanical, surgical abortion, sometimes following prostaglandin (PG) cervical gel priming, to be indispensable as a condition for successful in vitro elucidation of the etiopathogenesis of fetal diabetes. Extraamniotic PG induction of abortion has failed to yield any relevant information in that context. (author's)