Spin-label studies of erythrocytes in myotonic dystrophy: no increase in membrane fluidity.
Neurology
; 30(3): 272-6, 1980 Mar.
Article
em En
| MEDLINE
| ID: mdl-7189026
ABSTRACT
The basic defect in myotonic dystrophy is thought to involve muscle cell membranes. Butterfield and associates have recently presented electron spin resonance data that suggest increased fluidity of erythrocyte membranes in patients with myotonic dystrophy. We studied erythrocytes from 11 patients with myotonic dystrophy and 14 age-matched controls, using spin-labeled fatty acid and ester probes. Despite attempts to reproduce the previously reported experimental conditions exactly, we found no significant differences in the electron spin resonance spectra of erythrocytes from normal and myotonic dystrophy subjects. These findings do not provide evidence of increased erythrocyte membrane fluidity in myotonic dystrophy; they fail to support the concept of an intrinsic defect of the lipid membrane in this disorder.
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Bases de dados:
MEDLINE
Assunto principal:
Membrana Eritrocítica
/
Eritrócitos
/
Distrofias Musculares
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
1980
Tipo de documento:
Article