In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands.
Eur J Pharmacol
; 74(1): 73-81, 1981 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-7318895
ABSTRACT
Administration of the muscarinic agonist oxotremorine led to a decrease in the number of muscarinic receptors, as determined by specific binding of [3H]quinuclidinyl benzilate ([3H]QNB), in several rat brain regions both during development and at maturity. In contrast, administration of the muscarinic antagonist scopolamine led to an increase in the number of [3H]QNB-binding sites in various brain regions. Scopolamine also prevented the decrease in the number of [3H]QNB-binding sites induced by administration of an organophosphorus drug. The results are compatible with the hypothesis that the number of brain muscarinic receptors, or at least of a sub-class of them, is regulated by their transmitter.
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Bases de dados:
MEDLINE
Assunto principal:
Oxotremorina
/
Escopolamina
/
Receptores Colinérgicos
/
Receptores Muscarínicos
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1981
Tipo de documento:
Article