Further studies on the inhibition of monoamine synthesis by monofluoromethyldopa.
Br J Pharmacol
; 70(4): 571-6, 1980 Dec.
Article
em En
| MEDLINE
| ID: mdl-7470730
ABSTRACT
1 alpha-Monofluoromethyldopa (MFMD, RMI 71963), a potent and selective enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase produces a substantial and long-lasting decrease in the catecholamine content of mouse brain, heart and kidney. 2 Single doses of MFMD reduce the 5-hydroxytryptamine concentration of mouse brain without altering the tryptophan concentration. 3 In animals treated with MFMD, peripheral but not brain noradrenaline is restored within 1 h to control levels by an intraperitoneal injection of dopamine.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Catecolaminas
/
Inibidores das Descarboxilases de Aminoácidos Aromáticos
/
Metildopa
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1980
Tipo de documento:
Article