HIV-1 gp41 shares a common immunologic determinant with human T, B and monocyte cell lines.
Immunol Lett
; 39(3): 219-22, 1994 Mar.
Article
em En
| MEDLINE
| ID: mdl-7518416
ABSTRACT
Several examples of molecular mimicry between HIV-1 and human proteins are reported in the literature. Here we report on yet another example. The monoclonal antibody 3D6 recognized a 17-amino-acid region in HIV-1 gp41 (amino acids 602-618) and could bind to the human T-cell lines H9 and Molt4, B cell lines Raji and Bjab, and monocyte cell lines U937 and HL60. By Western blot using 3D6, a strong band of 43 kDa and a very weak band of 80 kDa were detected in lysates of H9, Molt4, Raji and Bjab cell lines, but only a strong band of 43 kDa was observed in case of U937 and HL60 cells, under reducing or non-reducing conditions. The results indicate the presence of a common immunologic determinant between HIV-1 gp41 and membrane proteins of these human T, B and monocyte cells.
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Bases de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Monócitos
/
Linfócitos T
/
Proteína gp41 do Envelope de HIV
/
HIV-1
/
Leucócitos
Limite:
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Áustria