Pregnancy and its outcome in systemic lupus erythematosus.
QJM
; 87(12): 721-9, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7859048
ABSTRACT
In a multi-centre prospective study of systemic lupus erythematosus and pregnancy in France, 117 cases were identified from 1987 to 1992. We report significant morbidity and mortality for mother and fetus from an analysis of 103 cases. Pregnancy outcome was as follows 28 full-term births, 48 premature births, 18 fetal losses (13 early and two late spontaneous abortions, three stillbirths), five therapeutic abortions and four elective abortions (for unwanted pregnancy). Four preterm neonates died. Lupus was active at pregnancy onset in 28 patients. Of 75 patients with inactive lupus at conception, 27 relapsed during pregnancy, and seven postpartum. Two patients with nephrotic syndrome treated with high-dose corticosteroids died from opportunistic infections. Fetal loss correlated with a history of proteinuria and absence of anti-SSA antibodies. Prematurity was related to a history of fetal loss, active lupus at pregnancy onset, hypertension and > or = 20 mg/day prednisone during pregnancy. Intrauterine growth retardation correlated with pregnancy of short duration, low serum C3 or C4, hypertension, and absence of SSA antibodies. Three of 22 newborns whose mothers had anti-SSA antibodies developed neonatal lupus two with cutaneous involvement and one with complete atrioventricular block.
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Bases de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
/
Newborn
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
QJM
Assunto da revista:
MEDICINA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
França