Normal values of cerebrovascular reserve capacity after stimulation with acetazolamide measured by xenon 133 single-photon emission CT.
AJNR Am J Neuroradiol
; 15(7): 1327-32, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7976945
ABSTRACT
PURPOSE:
To determine whether a standardized stimulation challenge with acetazolamide will be helpful for assessing the vasodilatory capacity in patients with obstructive cerebrovascular disease.METHODS:
To establish normative data of the cerebrovascular reserve capacity, a group of 41 control patients was investigated. The regional cerebral blood flow was measured quantitatively before and after stimulation with acetazolamide using the xenon 133 inhalation method and dynamic single-photon emission CT.RESULTS:
A significant increase of regional cerebral blood flow was found after administration of 1 g of acetazolamide. By doubling the dose no significant further increase was measured. We found no correlation of either baseline or stimulated flow values with age. However, a linear dependence between the stimulated flow values and their respective baseline values was observed.CONCLUSION:
The standardized challenge with acetazolamide seems to be a reliable method to determine cerebrovascular reserve capacity quantitatively.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vasodilatação
/
Radioisótopos de Xenônio
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Encéfalo
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Transtornos Cerebrovasculares
/
Acetazolamida
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha