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Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators.
Lecomte, E; Herbeth, B; Pirollet, P; Chancerelle, Y; Arnaud, J; Musse, N; Paille, F; Siest, G; Artur, Y.
Afiliação
  • Lecomte E; Laboratoire du Centre de Médecine Préventive (URA CNRS 597), Vandoeuvre-les-Nancy, France.
Am J Clin Nutr ; 60(2): 255-61, 1994 Aug.
Article em En | MEDLINE | ID: mdl-8030604
The effects of alcohol consumption on plasma concentrations of antioxidant vitamins (alpha-tocopherol and ascorbic acid), selenium, and markers of oxidative stress, especially malondialdehyde (MDA) and autoantibodies directed to MDA adducts to proteins (Ig-NH2-MDA) were investigated in a large population of 417 supposedly healthy men who consumed only low or moderate amounts of alcohol as compared with 102 alcoholic patients without severe liver disease, who were studied both before and after 21 d of withdrawal treatment. Plasma concentrations of alpha-tocopherol, ascorbic acid, and selenium were lower in alcoholics than in men who drank low amounts of alcohol (P < or = 0.001), whereas MDA and Ig-NH2-MDA were higher (P < or = 0.001). Plasma concentrations of alpha-tocopherol and selenium remained unchanged after the withdrawal period, whereas ascorbic acid (P < or = 0.01), MDA, and Ig-NH2-MDA concentrations decreased (P < or = 0.001). Adjustment of data for circulating lipids and nutritional intake suggests a specific effect of alcohol on antioxidant vitamins, independent of nutritional status.
Assuntos
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Bases de dados: MEDLINE Assunto principal: Ácido Ascórbico / Estresse Fisiológico / Vitamina E / Consumo de Bebidas Alcoólicas / Alcoolismo Limite: Adult / Humans / Male Idioma: En Revista: Am J Clin Nutr Ano de publicação: 1994 Tipo de documento: Article País de afiliação: França
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Bases de dados: MEDLINE Assunto principal: Ácido Ascórbico / Estresse Fisiológico / Vitamina E / Consumo de Bebidas Alcoólicas / Alcoolismo Limite: Adult / Humans / Male Idioma: En Revista: Am J Clin Nutr Ano de publicação: 1994 Tipo de documento: Article País de afiliação: França