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Effects of aluminum on the mechanical and electrical activity of the Langendorff-perfused rat heart.
Gomes, M G; Moreira, C A; Mill, J G; Massaroni, L; Oliveira, E M; Stefanon, I; Vassallo, D V.
Afiliação
  • Gomes MG; Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Brasil.
Braz J Med Biol Res ; 27(1): 95-100, 1994 Jan.
Article em En | MEDLINE | ID: mdl-8173535
The effect of aluminum (Al3+) chloride (1, 5, 10, 50 and 100 microM) on myocardial electromechanical activity was studied in 10 Langendorff-perfused hearts from adult female Wistar rats. Al3+ decreased the development of isovolumic systolic pressure from 34.3 +/- 2.95 mmHg under control conditions to 11.8 +/- 1.53 mmHg at 100 microM AlCl3 (P < 0.01) (diastolic pressure = 0 mmHg). The atrial and ventricular rates also decreased, but only with AlCl3 concentrations greater than 1 microM (from 180 +/- 5 to 94 +/- 11 bpm for atrial rate and from 180 +/- 5 to 78 +/- 7 bpm for ventricular rate). Reduction of coronary flow was also observed, reaching 60% at 100 microM Al3+. A delay in atrioventricular conduction occurred at 10 microM Al3+, increasing progressively up to 100 microM (62.3 +/- 4 ms in the Al(3+)-free solution to 143 +/- 34 ms in the presence of 100 microM Al3+, P < 0.01, ANOVA). QRS duration did not change as a function of increasing Al3+ concentrations (37.1 +/- 1.7 ms in the Al(3+)-free solution vs 32.1 +/- 1.6 ms in the presence of 100 microM Al3+). No qualitative changes in ECG were observed. These data show that the toxic effects of Al3+ on the myocardium are reflected in reduced systolic pressure development and coronary flow and increased PR interval. These effects are discussed in terms of the inhibition of nucleotide hydrolysis by Al3+.
Assuntos
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Bases de dados: MEDLINE Assunto principal: Cloretos / Alumínio / Coração Tipo de estudo: Qualitative_research Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Brasil
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Bases de dados: MEDLINE Assunto principal: Cloretos / Alumínio / Coração Tipo de estudo: Qualitative_research Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Brasil