High IL-6 serum levels are associated with septic shock and mortality in septic patients with severe leukopenia due to hematological malignancies.
Scand J Infect Dis
; 27(4): 381-4, 1995.
Article
em En
| MEDLINE
| ID: mdl-8658074
ABSTRACT
The serum levels of immunoreactive interleukin-6 (IL-6) and tumor necrosis factor (TNF) were analyzed in 14 leukopenic patients with documented sepsis, at 60 min (T0), 24 h (T1), and one week (T3) after the onset of sepsis syndrome. Sera from 10 leukopenic patients without sepsis (controls) were also tested. All septic patients had high IL-6 levels at T0. These levels persisted only in the seven patients who died of septic shock, presenting a 30-fold increase (p<0.001) as compared to the survivors and the controls. At T3, 7 survivors had recovered from sepsis and showed low IL-6 serum levels. The TNF serum concentration always <30 pg/ml in both the subjects and in the controls. The C-reactive protein (CRP) and clinical parameters appeared to be less specifically associated with shock and mortality than IL-6.
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Bases de dados:
MEDLINE
Assunto principal:
Choque Séptico
/
Linfoma não Hodgkin
/
Leucemia
/
Interleucina-6
/
Síndrome de Resposta Inflamatória Sistêmica
/
Leucopenia
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Scand J Infect Dis
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Itália