p53 immunoreaction in hepatocellular carcinoma and its relationship to etiologic factors. A fine needle aspiration study.
Acta Cytol
; 40(6): 1148-53, 1996.
Article
em En
| MEDLINE
| ID: mdl-8960021
ABSTRACT
OBJECTIVE:
To determine immunohistochemically the expression of mutant p53 phosphoprotein in hepatocellular carcinoma (HCC) and its possible relationship to several etiologic factors. STUDYDESIGN:
The study group consisted of 62 samples of HCC, grades 2, 3 and 4, obtained by fine needle aspiration cytology. The associated risk factors detected in these patients were as follows ethanol abuse, ethanol abuse plus hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, HBV infection, HCV infection, non-A/ non-B hepatitis, hemochromatosis and obesity.RESULTS:
Mutant p53 expression was identified in 22% of HCC and seemed to correlate with tumor grade. Positive immunostaining was frequently associated with a history of alcohol abuse (42%) and also with viral infection (HBV, 21%; HCV, 7%; non-A/non-B hepatitis, 7%).CONCLUSION:
Mutant p53 seems to intervene in the progress of HCC through various grades of increasing malignancy. The association we found between alcohol intake and mutant p53 expression may deserve further investigation.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Proteína Supressora de Tumor p53
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Cytol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Espanha