Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs.
Cardiovasc Res
; 32(6): 1008-15, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-9015403
ABSTRACT
OBJECTIVES:
Free fatty acid (FFA) oxidation is depressed in the postischaemic stunned myocardium and recovers in parallel with the normalization of contractile performance. Assuming a causal role for this metabolic disturbance in the pathogenesis of stunning, we questioned whether exogenous administration of high dose triglycerides during reperfusion of postischaemic myocardium, could improve its functional recovery.METHODS:
Thirteen dogs were chronically instrumented to measure global and regional haemodynamics and to produce a 10 min episode of regional myocardial ischaemia. In 7 dogs, Intralipid 20% was administered i.v. during the reperfusion phase. Contractile recovery of stunned myocardium was compared with control saline treatments. The series were repeated in another 6 animals, but oxfenicine (CPT I inhibitor) preceeded Intralipid during reperfusion.RESULTS:
Contractile recovery of stunned myocardium was faster and more extensive when Intralipid was administered during reperfusion than with saline treatment (wall thickening fraction 86 +/- 6% of preischaemic controls versus 52 +/- 11% at 90 min post-reperfusion; P < 0.05). Oxfenicine pretreatment completely abolished this beneficial effect.CONCLUSIONS:
Exogenous administration of triglycerides during reperfusion of postischaemic myocardium improves functional recovery from stunning. This beneficial effect most likely operates through enhanced FFA availability and/or oxidation since it could be abolished by selective inhibition of the carnitine palmitoyl I enzyme.
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Bases de dados:
MEDLINE
Assunto principal:
Triglicerídeos
/
Miocárdio Atordoado
/
Emulsões Gordurosas Intravenosas
/
Contração Miocárdica
Limite:
Animals
Idioma:
En
Revista:
Cardiovasc Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Bélgica