Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice.
J Clin Invest
; 99(3): 526-33, 1997 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-9022088
ABSTRACT
These studies tested the hypothesis that L-selectin plays a role in neutrophil traffic in the lungs, particularly in neutrophil margination, sequestration, and emigration, using L-selectin-deficient mice. No defect in neutrophil margination within either capillaries or arterioles and venules was observed in uninflamed lungs of L-selectin-deficient mice. The initial rapid sequestration of neutrophils within the pulmonary capillaries 1 min after intravascular injection of complement fragments was not prevented. In contrast, L-selectin did contribute to the prolonged neutrophil sequestration (> or = 5 min). Interestingly, neutrophil accumulation within noncapillary microvessels required L-selectin at both 1 and 5 min after complement injection. During bacterial pneumonias, L-selectin played a role in neutrophil accumulation within noncapillary microvessels in response to either Escherichia coli or Streptococcus pneumoniae and within capillaries in response to E. coli but not S. pneumoniae. However, L-selectin was not required for emigration of neutrophils or edema in response to either organism. These studies demonstrate a role for L-selectin in the prolonged sequestration of neutrophils in response to intravascular complement fragments, in the intracapillary accumulation of neutrophils during E. coli-induced pneumonia, and in the accumulation of neutrophils within noncapillary microvessels when induced by either intravascular complement fragments or
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Adesão Celular
/
Movimento Celular
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Mutagênese
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Selectina L
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Inflamação
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Pulmão
/
Neutrófilos
Limite:
Animals
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos