Trihexyphenidyl treatment of clozapine-induced hypersalivation.
Int Clin Psychopharmacol
; 12(4): 213-5, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9347382
ABSTRACT
The objective of this study was to investigate the efficacy of the anticholinergic agent trihexyphenidyl in the treatment of clozapine-induced hypersalivation. Fourteen chronic schizophrenic patients who exhibited nocturnal hypersalivation during clozapine treatment were coadministered trihexyphenidyl (5-15 mg/day, at bedtime) for 15 days. Salivation was assessed by a single-item 5-point scale. A reduction of 44% in the reported nocturnal hypersalivation was observed after trihexyphenidyl treatment. These results indicate that at least some chronic schizophrenic patients with clozapine-induced nocturnal hypersalivation may benefit from anticholinergic treatment.
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Bases de dados:
MEDLINE
Assunto principal:
Sialorreia
/
Antipsicóticos
/
Triexifenidil
/
Clozapina
/
Antagonistas Muscarínicos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int Clin Psychopharmacol
Assunto da revista:
PSICOFARMACOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Israel