Studies on therapeutic activity of benzoxazinorifamycin KRM-1648 in combination with other antimicrobial agents and biological response modifiers interferon-gamma and granulocyte-macrophage colony-stimulating factor against M. leprae infection in athymic nude mice.
Int J Lepr Other Mycobact Dis
; 65(3): 345-51, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9401487
ABSTRACT
In the present study, we evaluated the in vivo anti-Mycobacterium leprae activities of KRM-1648 (KRM) given at long intervals in combination with ofloxacin (OFLX), clofazimine (CFZ), and dapsone (DDS). We also examined the combined effects of two biological response modifiers (BRMs), gamma interferon (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF), on the therapeutic efficacy of KRM. KRM exhibited potent therapeutic efficacy against M. leprae infection in mice even when given at 4-week intervals. KRM displayed increased efficacy in combination with OFLX, CFZ, and DDS (given three or six times per week) when given to mice in the multidrug combination KRM + OFLX + CFZ + DDS. The therapeutic efficacy of KRM given at 4-week intervals was increased by combined use with IFN-gamma but not by GM-CSF. Adoptive transfer of M. leprae antigen-primed lymphocytes of euthymic mice to recipient athymic nude mice with progressive M. leprae infection markedly enhanced host resistance.
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Bases de dados:
MEDLINE
Assunto principal:
Rifamicinas
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Interferon gama
/
Fatores Imunológicos
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Hansenostáticos
/
Hanseníase
Limite:
Animals
Idioma:
En
Revista:
Int J Lepr Other Mycobact Dis
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão