Dependence of BSAP repressor and activator functions on BSAP concentration.
Science
; 279(5358): 1961-4, 1998 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-9506950
During a B cell immune response, the transcription factor BSAP maintains its activator functions but is relieved of its repressor functions. This selective targeting of BSAP activities was shown to be regulated by a concentration-dependent mechanism whereby activator motifs for BSAP had a 20-fold higher binding affinity than repressor motifs. An exchange of activator and repressor motifs, however, showed that the context of the motif, rather than the affinity, determined whether BSAP operated as an activator or repressor.
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Bases de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Nucleares
/
Linfócitos B
/
Sequências Reguladoras de Ácido Nucleico
/
Regulação da Expressão Gênica
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos