Culture substrate-specific expression of P2Y2 receptors in distal lung epithelial cells isolated from foetal rats.
Br J Pharmacol
; 124(5): 845-7, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9692767
ABSTRACT
ATP and UTP did not evoke [Ca2+]i signals in rat foetal lung epithelial cells grown on glass but elicited clear responses in cells grown into functionally polarised epithelia on permeable supports. Moreover, P2Y2 receptor mRNA could not be detected in cells on glass by the polymerase chain reaction but this mRNA species was clearly expressed by polarised cells. P2Y2 receptor expression thus appears to be a feature of the polarised phenotype.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptores Purinérgicos P2
/
Células Epiteliais
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1998
Tipo de documento:
Article