GC/MS analysis of m-hydroxybenzoylecgonine in urine. Forensic implication in cocaine use.
Clin Lab Med
; 18(4): 699-704, ix, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9891608
ABSTRACT
m-Hydroxybenzoylecgonine (m-OH-BE) and d3-m- hydroxybenzoylecgonine (d3-m-OH-BE) have been synthesized, and a GC/MS procedure with d3-m-OH-BE as internal standard has been developed. Among 24 human urine specimens that were positive for BE, all of them have shown detectable levels of m-OH-BE with 75% of the specimens exceeding the LoQ (5 ng/mL), compared with only 50% of the specimens containing detectable levels of EME. The presence of m-OH-BE in urine suggested that this metabolite may serve as a valuable marker of cocaine use in addition to BE and EME.
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Bases de dados:
MEDLINE
Assunto principal:
Cocaína
/
Transtornos Relacionados ao Uso de Cocaína
/
Medicina Legal
/
Cromatografia Gasosa-Espectrometria de Massas
Limite:
Humans
Idioma:
En
Revista:
Clin Lab Med
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos