Detalhe da pesquisa
1.
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
Mol Cell
; 81(2): 239-254.e8, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33301730
2.
Molecular basis of polycomb group protein-mediated fetal hemoglobin repression.
Blood
; 141(22): 2756-2770, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893455
3.
The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine.
Blood
; 140(15): 1723-1734, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35977098
4.
The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression.
Blood
; 135(24): 2121-2132, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32299090
5.
Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts.
Blood
; 135(22): 1957-1968, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32268371
6.
Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia.
Haematologica
; 107(2): 532-540, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33567814
7.
Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies.
Mol Ther
; 29(4): 1625-1638, 2021 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515514
8.
Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities.
Int J Mol Sci
; 23(13)2022 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35806451
9.
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
Molecules
; 27(20)2022 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36296435
10.
2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 ß-thalassemia patient cells restoring HbA production and chain rebalance.
Haematologica
; 106(5): 1433-1442, 2019 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32439726
11.
Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients.
Am J Hematol
; 94(5): 575-584, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30784099
12.
Erythropoietin Prevents Anemia and Transfusions in Extremely Premature Lambs Supported by an EXTrauterine Environment for Neonatal Development (EXTEND).
Fetal Diagn Ther
; 46(4): 231-237, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30703769
13.
Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy.
Can Vet J
; 60(5): 502-506, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31080263
14.
T2 -prepared balanced steady-state free precession (bSSFP) for quantifying whole-blood oxygen saturation at 1.5T.
Magn Reson Med
; 79(4): 1893-1900, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28718522
15.
Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.
Blood
; 128(8): 1139-43, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27405777
16.
A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.
Mol Pharm
; 15(5): 1954-1963, 2018 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29634905
17.
Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.
Bioorg Med Chem
; 26(9): 2530-2538, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29655608
18.
Correction of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants.
Blood
; 126(10): 1245-54, 2015 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124498
19.
Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.
Mol Pharm
; 14(10): 3499-3511, 2017 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28858508
20.
Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation.
J Struct Biol
; 194(3): 446-50, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27085422