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1.
Proc Natl Acad Sci U S A ; 115(11): E2566-E2574, 2018 03 13.
Artigo em Inglês | MEDLINE | ID: mdl-29483247

RESUMO

Elephantids are the world's most iconic megafaunal family, yet there is no comprehensive genomic assessment of their relationships. We report a total of 14 genomes, including 2 from the American mastodon, which is an extinct elephantid relative, and 12 spanning all three extant and three extinct elephantid species including an ∼120,000-y-old straight-tusked elephant, a Columbian mammoth, and woolly mammoths. Earlier genetic studies modeled elephantid evolution via simple bifurcating trees, but here we show that interspecies hybridization has been a recurrent feature of elephantid evolution. We found that the genetic makeup of the straight-tusked elephant, previously placed as a sister group to African forest elephants based on lower coverage data, in fact comprises three major components. Most of the straight-tusked elephant's ancestry derives from a lineage related to the ancestor of African elephants while its remaining ancestry consists of a large contribution from a lineage related to forest elephants and another related to mammoths. Columbian and woolly mammoths also showed evidence of interbreeding, likely following a latitudinal cline across North America. While hybridization events have shaped elephantid history in profound ways, isolation also appears to have played an important role. Our data reveal nearly complete isolation between the ancestors of the African forest and savanna elephants for ∼500,000 y, providing compelling justification for the conservation of forest and savanna elephants as separate species.


Assuntos
Elefantes/genética , Mamutes/genética , Mastodontes/genética , Animais , Elefantes/classificação , Evolução Molecular , Extinção Biológica , Fósseis , Fluxo Gênico , Genoma , Genômica/história , História Antiga , Mamutes/classificação , Mastodontes/classificação , Filogenia
2.
Nucleic Acids Res ; 46(D1): D221-D228, 2018 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-29126148

RESUMO

The Consensus Coding Sequence (CCDS) project provides a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assembly in genome annotations produced independently by NCBI and the Ensembl group at EMBL-EBI. This dataset is the product of an international collaboration that includes NCBI, Ensembl, HUGO Gene Nomenclature Committee, Mouse Genome Informatics and University of California, Santa Cruz. Identically annotated coding regions, which are generated using an automated pipeline and pass multiple quality assurance checks, are assigned a stable and tracked identifier (CCDS ID). Additionally, coordinated manual review by expert curators from the CCDS collaboration helps in maintaining the integrity and high quality of the dataset. The CCDS data are available through an interactive web page (https://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi) and an FTP site (ftp://ftp.ncbi.nlm.nih.gov/pub/CCDS/). In this paper, we outline the ongoing work, growth and stability of the CCDS dataset and provide updates on new collaboration members and new features added to the CCDS user interface. We also present expert curation scenarios, with specific examples highlighting the importance of an accurate reference genome assembly and the crucial role played by input from the research community.


Assuntos
Sequência Consenso , Bases de Dados Genéticas , Fases de Leitura Aberta , Animais , Curadoria de Dados/métodos , Curadoria de Dados/normas , Bases de Dados Genéticas/normas , Guias como Assunto , Humanos , Camundongos , Anotação de Sequência Molecular , National Library of Medicine (U.S.) , Estados Unidos , Interface Usuário-Computador
3.
Nucleic Acids Res ; 45(D1): D635-D642, 2017 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-27899575

RESUMO

Ensembl (www.ensembl.org) is a database and genome browser for enabling research on vertebrate genomes. We import, analyse, curate and integrate a diverse collection of large-scale reference data to create a more comprehensive view of genome biology than would be possible from any individual dataset. Our extensive data resources include evidence-based gene and regulatory region annotation, genome variation and gene trees. An accompanying suite of tools, infrastructure and programmatic access methods ensure uniform data analysis and distribution for all supported species. Together, these provide a comprehensive solution for large-scale and targeted genomics applications alike. Among many other developments over the past year, we have improved our resources for gene regulation and comparative genomics, and added CRISPR/Cas9 target sites. We released new browser functionality and tools, including improved filtering and prioritization of genome variation, Manhattan plot visualization for linkage disequilibrium and eQTL data, and an ontology search for phenotypes, traits and disease. We have also enhanced data discovery and access with a track hub registry and a selection of new REST end points. All Ensembl data are freely released to the scientific community and our source code is available via the open source Apache 2.0 license.


Assuntos
Biologia Computacional/métodos , Bases de Dados Genéticas , Genômica/métodos , Ferramenta de Busca , Software , Navegador , Animais , Mineração de Dados , Evolução Molecular , Regulação da Expressão Gênica , Variação Genética , Genoma Humano , Humanos , Anotação de Sequência Molecular , Especificidade da Espécie , Vertebrados
4.
Nature ; 491(7424): 393-8, 2012 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-23151582

RESUMO

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.


Assuntos
Genoma/genética , Filogenia , Sus scrofa/classificação , Sus scrofa/genética , Animais , Demografia , Modelos Animais , Dados de Sequência Molecular , Dinâmica Populacional
5.
Nucleic Acids Res ; 44(D1): D710-6, 2016 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-26687719

RESUMO

The Ensembl project (http://www.ensembl.org) is a system for genome annotation, analysis, storage and dissemination designed to facilitate the access of genomic annotation from chordates and key model organisms. It provides access to data from 87 species across our main and early access Pre! websites. This year we introduced three newly annotated species and released numerous updates across our supported species with a concentration on data for the latest genome assemblies of human, mouse, zebrafish and rat. We also provided two data updates for the previous human assembly, GRCh37, through a dedicated website (http://grch37.ensembl.org). Our tools, in particular the VEP, have been improved significantly through integration of additional third party data. REST is now capable of larger-scale analysis and our regulatory data BioMart can deliver faster results. The website is now capable of displaying long-range interactions such as those found in cis-regulated datasets. Finally we have launched a website optimized for mobile devices providing views of genes, variants and phenotypes. Our data is made available without restriction and all code is available from our GitHub organization site (http://github.com/Ensembl) under an Apache 2.0 license.


Assuntos
Bases de Dados Genéticas , Genômica , Anotação de Sequência Molecular , Animais , Genes , Variação Genética , Humanos , Internet , Camundongos , Proteínas/genética , Ratos , Sequências Reguladoras de Ácido Nucleico , Software
6.
Nucleic Acids Res ; 43(Database issue): D662-9, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25352552

RESUMO

Ensembl (http://www.ensembl.org) is a genomic interpretation system providing the most up-to-date annotations, querying tools and access methods for chordates and key model organisms. This year we released updated annotation (gene models, comparative genomics, regulatory regions and variation) on the new human assembly, GRCh38, although we continue to support researchers using the GRCh37.p13 assembly through a dedicated site (http://grch37.ensembl.org). Our Regulatory Build has been revamped to identify regulatory regions of interest and to efficiently highlight their activity across disparate epigenetic data sets. A number of new interfaces allow users to perform large-scale comparisons of their data against our annotations. The REST server (http://rest.ensembl.org), which allows programs written in any language to query our databases, has moved to a full service alongside our upgraded website tools. Our online Variant Effect Predictor tool has been updated to process more variants and calculate summary statistics. Lastly, the WiggleTools package enables users to summarize large collections of data sets and view them as single tracks in Ensembl. The Ensembl code base itself is more accessible: it is now hosted on our GitHub organization page (https://github.com/Ensembl) under an Apache 2.0 open source license.


Assuntos
Bases de Dados de Ácidos Nucleicos , Genômica , Animais , Epigênese Genética , Variação Genética , Genoma Humano , Humanos , Internet , Camundongos , Anotação de Sequência Molecular , Sequências Reguladoras de Ácido Nucleico , Software
7.
Proc Natl Acad Sci U S A ; 111(48): 17230-5, 2014 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-25385592

RESUMO

Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with behavior and reward in mouse models, as predicted by the domestication syndrome hypothesis. Our description of a previously unidentified allele for the gloving pigmentation pattern found in the Birman breed supports the hypothesis that cat breeds experienced strong selection on specific mutations drawn from random bred populations. Collectively, these findings provide insight into how the process of domestication altered the ancestral wildcat genome and build a resource for future disease mapping and phylogenomic studies across all members of the Felidae.


Assuntos
Animais Domésticos/genética , Animais Selvagens/genética , Gatos/genética , Genoma/genética , Genômica/métodos , Adaptação Fisiológica/genética , Sequência de Aminoácidos , Animais , Carnivoridade , Gatos/classificação , Mapeamento Cromossômico , Variações do Número de Cópias de DNA , Cães , Feminino , Deleção de Genes , Duplicação Gênica , Masculino , Proteínas de Membrana Transportadoras/classificação , Proteínas de Membrana Transportadoras/genética , Dados de Sequência Molecular , Filogenia , Seleção Genética/genética , Análise de Sequência de DNA , Homologia de Sequência de Aminoácidos , Especificidade da Espécie
8.
Nucleic Acids Res ; 42(Database issue): D749-55, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24316576

RESUMO

Ensembl (http://www.ensembl.org) creates tools and data resources to facilitate genomic analysis in chordate species with an emphasis on human, major vertebrate model organisms and farm animals. Over the past year we have increased the number of species that we support to 77 and expanded our genome browser with a new scrollable overview and improved variation and phenotype views. We also report updates to our core datasets and improvements to our gene homology relationships from the addition of new species. Our REST service has been extended with additional support for comparative genomics and ontology information. Finally, we provide updated information about our methods for data access and resources for user training.


Assuntos
Bases de Dados Genéticas , Genômica , Animais , Cordados/genética , Variação Genética , Humanos , Internet , Camundongos , Anotação de Sequência Molecular , Fenótipo , Ratos
9.
Genome Res ; 22(9): 1698-710, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22955982

RESUMO

Within the ENCODE Consortium, GENCODE aimed to accurately annotate all protein-coding genes, pseudogenes, and noncoding transcribed loci in the human genome through manual curation and computational methods. Annotated transcript structures were assessed, and less well-supported loci were systematically, experimentally validated. Predicted exon-exon junctions were evaluated by RT-PCR amplification followed by highly multiplexed sequencing readout, a method we called RT-PCR-seq. Seventy-nine percent of all assessed junctions are confirmed by this evaluation procedure, demonstrating the high quality of the GENCODE gene set. RT-PCR-seq was also efficient to screen gene models predicted using the Human Body Map (HBM) RNA-seq data. We validated 73% of these predictions, thus confirming 1168 novel genes, mostly noncoding, which will further complement the GENCODE annotation. Our novel experimental validation pipeline is extremely sensitive, far more than unbiased transcriptome profiling through RNA sequencing, which is becoming the norm. For example, exon-exon junctions unique to GENCODE annotated transcripts are five times more likely to be corroborated with our targeted approach than with extensive large human transcriptome profiling. Data sets such as the HBM and ENCODE RNA-seq data fail sampling of low-expressed transcripts. Our RT-PCR-seq targeted approach also has the advantage of identifying novel exons of known genes, as we discovered unannotated exons in ~11% of assessed introns. We thus estimate that at least 18% of known loci have yet-unannotated exons. Our work demonstrates that the cataloging of all of the genic elements encoded in the human genome will necessitate a coordinated effort between unbiased and targeted approaches, like RNA-seq and RT-PCR-seq.


Assuntos
Perfilação da Expressão Gênica/métodos , Genoma Humano , Transcriptoma , Biologia Computacional/métodos , Éxons , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Íntrons , Anotação de Sequência Molecular , Fases de Leitura Aberta , Isoformas de RNA , RNA Mensageiro/química , RNA Mensageiro/genética , Reprodutibilidade dos Testes , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Sensibilidade e Especificidade
10.
Genome Res ; 22(9): 1760-74, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22955987

RESUMO

The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation data set, few new protein-coding loci have been added, yet the number of alternative splicing transcripts annotated has steadily increased. The GENCODE 7 release contains 20,687 protein-coding and 9640 long noncoding RNA loci and has 33,977 coding transcripts not represented in UCSC genes and RefSeq. It also has the most comprehensive annotation of long noncoding RNA (lncRNA) loci publicly available with the predominant transcript form consisting of two exons. We have examined the completeness of the transcript annotation and found that 35% of transcriptional start sites are supported by CAGE clusters and 62% of protein-coding genes have annotated polyA sites. Over one-third of GENCODE protein-coding genes are supported by peptide hits derived from mass spectrometry spectra submitted to Peptide Atlas. New models derived from the Illumina Body Map 2.0 RNA-seq data identify 3689 new loci not currently in GENCODE, of which 3127 consist of two exon models indicating that they are possibly unannotated long noncoding loci. GENCODE 7 is publicly available from gencodegenes.org and via the Ensembl and UCSC Genome Browsers.


Assuntos
Bases de Dados Genéticas , Genoma Humano , Genômica/métodos , Anotação de Sequência Molecular , Animais , Biologia Computacional/métodos , DNA Complementar/química , DNA Complementar/genética , Evolução Molecular , Éxons , Loci Gênicos , Humanos , Internet , Modelos Moleculares , Fases de Leitura Aberta , Pseudogenes , Controle de Qualidade , Sítios de Splice de RNA , RNA Longo não Codificante , Reprodutibilidade dos Testes , Regiões não Traduzidas
11.
Nucleic Acids Res ; 41(Database issue): D48-55, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23203987

RESUMO

The Ensembl project (http://www.ensembl.org) provides genome information for sequenced chordate genomes with a particular focus on human, mouse, zebrafish and rat. Our resources include evidenced-based gene sets for all supported species; large-scale whole genome multiple species alignments across vertebrates and clade-specific alignments for eutherian mammals, primates, birds and fish; variation data resources for 17 species and regulation annotations based on ENCODE and other data sets. Ensembl data are accessible through the genome browser at http://www.ensembl.org and through other tools and programmatic interfaces.


Assuntos
Bases de Dados Genéticas , Genômica , Animais , Regulação da Expressão Gênica , Variação Genética , Humanos , Internet , Camundongos , Anotação de Sequência Molecular , Ratos , Software , Peixe-Zebra/genética
12.
Nucleic Acids Res ; 40(Database issue): D84-90, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22086963

RESUMO

The Ensembl project (http://www.ensembl.org) provides genome resources for chordate genomes with a particular focus on human genome data as well as data for key model organisms such as mouse, rat and zebrafish. Five additional species were added in the last year including gibbon (Nomascus leucogenys) and Tasmanian devil (Sarcophilus harrisii) bringing the total number of supported species to 61 as of Ensembl release 64 (September 2011). Of these, 55 species appear on the main Ensembl website and six species are provided on the Ensembl preview site (Pre!Ensembl; http://pre.ensembl.org) with preliminary support. The past year has also seen improvements across the project.


Assuntos
Bases de Dados Genéticas , Genômica , Animais , Regulação da Expressão Gênica , Variação Genética , Humanos , Camundongos , Anotação de Sequência Molecular , Ratos
13.
Nucleic Acids Res ; 39(Database issue): D800-6, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21045057

RESUMO

The Ensembl project (http://www.ensembl.org) seeks to enable genomic science by providing high quality, integrated annotation on chordate and selected eukaryotic genomes within a consistent and accessible infrastructure. All supported species include comprehensive, evidence-based gene annotations and a selected set of genomes includes additional data focused on variation, comparative, evolutionary, functional and regulatory annotation. The most advanced resources are provided for key species including human, mouse, rat and zebrafish reflecting the popularity and importance of these species in biomedical research. As of Ensembl release 59 (August 2010), 56 species are supported of which 5 have been added in the past year. Since our previous report, we have substantially improved the presentation and integration of both data of disease relevance and the regulatory state of different cell types.


Assuntos
Bases de Dados Genéticas , Genômica , Animais , Variação Genética , Humanos , Camundongos , Anotação de Sequência Molecular , Ratos , Sequências Reguladoras de Ácido Nucleico , Software , Peixe-Zebra/genética
14.
Nucleic Acids Res ; 38(Database issue): D557-62, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19906699

RESUMO

Ensembl (http://www.ensembl.org) integrates genomic information for a comprehensive set of chordate genomes with a particular focus on resources for human, mouse, rat, zebrafish and other high-value sequenced genomes. We provide complete gene annotations for all supported species in addition to specific resources that target genome variation, function and evolution. Ensembl data is accessible in a variety of formats including via our genome browser, API and BioMart. This year marks the tenth anniversary of Ensembl and in that time the project has grown with advances in genome technology. As of release 56 (September 2009), Ensembl supports 51 species including marmoset, pig, zebra finch, lizard, gorilla and wallaby, which were added in the past year. Major additions and improvements to Ensembl since our previous report include the incorporation of the human GRCh37 assembly, enhanced visualisation and data-mining options for the Ensembl regulatory features and continued development of our software infrastructure.


Assuntos
Biologia Computacional/métodos , Bases de Dados Genéticas , Bases de Dados de Ácidos Nucleicos , Acesso à Informação , Animais , Biologia Computacional/tendências , Bases de Dados de Proteínas , Variação Genética , Genômica/métodos , Humanos , Armazenamento e Recuperação da Informação/métodos , Internet , Estrutura Terciária de Proteína , Software , Especificidade da Espécie
16.
Nat Genet ; 49(12): 1714-1721, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29083405

RESUMO

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.


Assuntos
Chlorocebus aethiops/genética , Perfilação da Expressão Gênica , Variação Genética , Locos de Características Quantitativas/genética , Animais , Encéfalo/crescimento & desenvolvimento , Encéfalo/metabolismo , Chlorocebus aethiops/crescimento & desenvolvimento , Estudo de Associação Genômica Ampla , Genótipo , Humanos , Fenótipo , Polimorfismo de Nucleotídeo Único
17.
Artigo em Inglês | MEDLINE | ID: mdl-27337980

RESUMO

The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological sequences, including cDNAs, proteins and RNA-seq reads, to the target genome in order to construct candidate transcript models. Careful assessment and filtering of these candidate transcripts ultimately leads to the final gene set, which is made available on the Ensembl website. Here, we describe the annotation process in detail.Database URL: http://www.ensembl.org/index.html.


Assuntos
Bases de Dados de Ácidos Nucleicos , Bases de Dados de Proteínas , Internet , Anotação de Sequência Molecular/métodos , Animais , Humanos , Camundongos
18.
Genome Biol ; 16: 21, 2015 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-25723810

RESUMO

Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released by the Avian Phylogenomics Consortium.


Assuntos
Aves/genética , Bases de Dados Genéticas , Genoma , Genômica , Animais
19.
Science ; 344(6188): 1168-1173, 2014 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-24904168

RESUMO

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.


Assuntos
Metabolismo dos Lipídeos/fisiologia , Rúmen/fisiologia , Carneiro Doméstico/genética , Carneiro Doméstico/metabolismo , Sequência de Aminoácidos , Animais , Ácidos Graxos Voláteis/metabolismo , Ácidos Graxos Voláteis/fisiologia , Regulação da Expressão Gênica , Genoma , Queratinas Específicas do Cabelo/genética , Metabolismo dos Lipídeos/genética , Dados de Sequência Molecular , Filogenia , Rúmen/metabolismo , Carneiro Doméstico/classificação , Transcriptoma , Lã/crescimento & desenvolvimento
20.
Nat Genet ; 45(4): 415-21, 421e1-2, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23435085

RESUMO

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provide insight into the ancestry of vertebrate genomes and the underlying principles of vertebrate biology. Here, we present the first lamprey whole-genome sequence and assembly. We note challenges faced owing to its high content of repetitive elements and GC bases, as well as the absence of broad-scale sequence information from closely related species. Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages. Moreover, the results help define key evolutionary events within vertebrate lineages, including the origin of myelin-associated proteins and the development of appendages. The lamprey genome provides an important resource for reconstructing vertebrate origins and the evolutionary events that have shaped the genomes of extant organisms.


Assuntos
Mapeamento Cromossômico , Evolução Molecular , Genoma , Petromyzon/genética , Vertebrados/genética , Animais , Filogenia , Sequências Repetitivas de Ácido Nucleico , Análise de Sequência de DNA
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