Detalhe da pesquisa
1.
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Proc Natl Acad Sci U S A
; 118(21)2021 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34006641
2.
Allosteric pluripotency: challenges and opportunities.
Biochem J
; 479(7): 825-838, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35403669
3.
CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery.
Bioinformatics
; 37(8): 1176-1177, 2021 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32926121
4.
Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase.
J Biol Chem
; 295(25): 8480-8491, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32317283
5.
Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal 15N-R2 Correlation Matrices.
J Am Chem Soc
; 143(12): 4668-4679, 2021 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-33733753
6.
Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding.
Biophys J
; 119(6): 1135-1146, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882185
7.
Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone.
J Am Chem Soc
; 142(21): 9686-9699, 2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32383602
8.
Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia.
J Biol Chem
; 292(15): 6414-6428, 2017 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28174302
9.
Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.
PLoS Biol
; 13(11): e1002305, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26618408
10.
Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.
J Biol Chem
; 290(29): 17642-17654, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25944904
11.
Signaling through dynamic linkers as revealed by PKA.
Proc Natl Acad Sci U S A
; 110(35): 14231-6, 2013 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23946424
12.
A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins.
J Biol Chem
; 289(5): 2589-99, 2014 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-24285546
13.
A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.
J Biol Chem
; 289(32): 22205-20, 2014 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24878962
14.
Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR.
J Am Chem Soc
; 137(33): 10777-85, 2015 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26247242
15.
Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.
Biochem Soc Trans
; 42(2): 302-7, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646235
16.
Allosteric linkers in cAMP signalling.
Biochem Soc Trans
; 42(1): 139-44, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450641
17.
Early-Onset Parkinson Mutation Remodels Monomer-Fibril Interactions to Allosterically Amplify Synuclein's Amyloid Cascade.
JACS Au
; 3(12): 3485-3493, 2023 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38155658
18.
cAMP-dependent allostery and dynamics in Epac: an NMR view.
Biochem Soc Trans
; 40(1): 219-23, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22260694
19.
Non-Canonical Allostery in Cyclic Nucleotide Dependent Kinases.
J Mol Biol
; 434(17): 167584, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35427632
20.
QSAR models reveal new EPAC-selective allosteric modulators.
RSC Chem Biol
; 3(10): 1230-1239, 2022 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36320893