Assessment of the effect of pulsed electromagnetic field application on the healing of bone defects in rats with heparin-induced osteoporosis.

Osteoporosis is a systemic skeletal disease characterized by an increase in bone fragility and fracture risk due to low bone mass and deterioration of bone tissue. Application of pulsed electromagnetic fields (PEMF), a non-invasive method with a low complication risk, is known to stimulate bone formation. The present study examines the histomorphometric and biochemical effects of PEMF application on the healing of bone defects in rats with heparin-induced secondary osteoporosis. Briefly, 12-month-old male Sprague-Dawley rats were examined in a prospective, randomized, single-blind study. Osteoporosis was induced by administering a daily dose of 2 IU/g heparin for 33 days. Bone defects were created on the right femur on Day 35. PEMF of an average intensity of 0.8 ± 0.2 mT and a frequency of 7.3 Hz, was applied for 1 h/day, for 28 days following surgery. Bone healing was evaluated by histomorphometric and biochemical analyses. The heparin + PEMF group displayed the largest amount of new bone area (P = .002) and the lowest mean CTx on Day 63 (P = .05). This study demonstrates that heparin administration leads to bone loss and osteoporosis, whereas the application of PEMF decreases this effect.

Distribution and pattern of implant therapy in a part of the Turkish population.

OBJECTIVE: To report the distribution and pattern of implant replacement of missing tooth/teeth. METHODS: This retrospective study was conducted at the Suleyman Demirel University, Isparta, Turkey, and used data of patients who had undergone implant replacement of missing teeth/tooth from May 2008 to May 2013. Data analysis included age, gender, number of implants placed, implant location distribution, additional surgery protocol, type of dentures and failure rate. SPSS 12 was used for data analysis. RESULTS: A total of 843 dental implants were performed on 280 patients, 143(51.1%) of whom were men and 137(48.9%) women. Besides, 89(31.8%) of all the participants were aged between 40-49 years. Moreover, 218(77.9%) patients received fixed dentures and 62(22.1%) received overdentures. The posterior region of mandible was the location in 281(33.3%) implants. Bone augmentation was performed in 152(54.3%) patients. Hard tissue grafting with sentetic bone grafts was used in 125(63.8%) patients. Failure was observed in 23(2.7%) implants. CONCLUSIONS: The relationships between denture type and age, and denture type and additional surgery were statistically significant.

Clinical impact of ectopic teeth in the maxillary sinus.

OBJECTIVE: To evaluate the clinical features, aetiologic factors, challenging properties (such as radio opacity in Water's view in a patient with no sinusitis), signs and symptoms of the ectopic teeth in the maxillary sinus. STUDY DESIGN: Clinical symptoms and radiographic findings of 14 patients with ectopic teeth in the maxillary sinus were evaluated. Computed tomography (CT) and conventional radiographic images of maxillary sinus and clinical findings were compared with each other with regard to the final diagnosis. RESULTS: Water's view is inadequate to diagnose ectopic tooth in the maxillary sinus in some cases. Panoramic radiographs may be preferred before CT to evaluate the ectopic tooth in the maxillary sinus as structure of a tooth can be clearly detected on panoramic radiographs. Crowding was the most common aetiologic factor among the 14 cases. CONCLUSION AND SIGNIFICANCE: The patients with ectopic tooth in the maxillary sinus should be evaluated thoroughly by complete otorhinolaryngologic, intraoral examinations and proper diagnostic imaging procedures in order to avoid misdiagnosis of maxillary sinusitis. As the opacity of the maxillary sinus in Water's view due to ectopic tooth can be misinterpreted as maxillary sinusitis, patients who have sinusitis-like complaints and opacity of maxillary sinus in Water's view who are resistant to medical treatment should be evaluated with respect to the presence of ectopic tooth.

Effects of resveratrol and cigarette smoking onbone healing: histomorphometric evaluation.

BACKGROUND/AIM: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. MATERIALS AND METHODS: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number of osteoblasts and osteoclasts, as well as new bone area, was conducted. RESULTS: Investigations were carried out on 33 rats. Differences between osteoblast numbers in the control and CS groups were significant, and CS caused a reduction in the number of osteoblasts. Areas of new bone formation in the resveratrol and control groups were higher than in the smoking and smoking+resveratrol groups. CONCLUSION: Smoking appeared to have adverse effects upon bone healing and resveratrol administration helped to reduce these effects.

The role of thrombofilia related to Factor V Leiden and Factor II G20210A mutations in recurrent abortions.

OBJECTIVE: To study, the impact of thrombophilia caused by Factor V, Factor ll G20210A mutations on recurrent abortions, the prevelance of Factor V Leiden and Factor II G20210A mutation in patients with habitual abortions. METHODS: Forty one patients with a diagnosis of habitual abortion were enrolled in the study. Control group consisted of 50 women without a history of poor obstetric outcome. 10 ml. peripheral venous blood was taken from study and control groups and transferred to EDTA tubes, and were tested for Factor V Leiden and Factor II G20210A mutations by PCR in genetics laboratory. RESULTS: Phenotypes of 91 cases were determined by PCR for Factor V Leiden. It was established that of 41 patients in the study group, 31 (75.6%) had GG genotype, 9 (22%) had GA genotype and 1 (2.4%) had AA genotype. In the control group, 45 (90%) of 50 women had GG genotype and 5 (10%) had GA genotype. A allele carrier status was found to be 24.4% in study group and 10% in the control group. The difference between them was not statistically significant (p = 0.06). CONCLUSIONS: The results obtained from patients and control group have no difference in Factor V Leiden and Factor II G20210A mutations.These results suggest that mutations have no role in etiology of 1. and 2. trimester recurrent abortions.

Unusual unilateral fracture of the condylar and coronoid processes of the mandible.

The incidence of condylar fracture is very high and most are not caused by direct trauma. On the other hand, fracture of the coronoid process is reported less often than fracture of other parts of the mandible. We report a case of right subcondylar and coronoid fractures without any evidence of direct trauma to the zygomatic area or an indirect trauma to the mandibular corpus or sypmheseal region. The possible cause was identified as acute reflex contraction of the temporalis muscles leading to coronoid and condylar stress fractures.

Garlic burn in a patient with trigeminal neuralgia: a case report.

Garlic is an herb which has been used by many cultures for treating various health problems for centuries. Uncontrolled use of herbal remedies, known as alternative treatment methods, may lead to side effects and serious treatment complications. This study aimed to draw attention to complications related to alternative treatment methods and to review the literature in the light of this case.A female patient who had been treated for trigeminal neuralgia was admitted to our clinic complaining of severe pain on the left side of her face. In anamnesis, the patient reported that she had applied garlic topically to this region. Extraoral examination revealed a broad cutaneous burn on the same region. According to a dermatology consultation, a treatment for cutaneous burns was applied and severe trigeminal neuralgia pain was eliminated with glycerol injection by an oral and maxillofacial surgeon.