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1.
Psychol Res ; 84(1): 111-119, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29349507

RESUMO

Two hallmarks of insightful problem solving are thought to be suddenness in the emergence of solution due to changes in problem representation, and the subjective Aha! experience. Although a number of studies have explored the Aha! experience, few studies have attempted to measure representational change. Following the lead of Durso et al. (Psychol Sci 5(2):94-97, 1994) and Cushen and Wiley (Conscious Cognit 21(3):1166-1175, 2012), in this study, participants made importance-to-solution ratings throughout their solution attempts as a way to assess representational change. Participants viewed a set of magic trick videos with the task of finding out how each trick worked, and rated six action verbs for each trick (including one that implied the correct solution) multiple times during solution. They were also asked to indicate the extent to which they experienced an Aha! moment. Patterns of ratings that showed a sudden change towards a correct solution led to stronger Aha! experiences than patterns that showed a more incremental change towards a correct solution, or a change towards incorrect solutions. The results show a connection between sudden changes in problem representations (leading to correct solutions) and the subjective appraisal of solutions as an Aha! experience. This offers the first empirical support for a close relationship between two theoretical constructs that have traditionally been assumed to be related to insightful problem solving.


Assuntos
Estado de Consciência/fisiologia , Criatividade , Tomada de Decisões/fisiologia , Emoções/fisiologia , Resolução de Problemas/fisiologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Meio-Oeste dos Estados Unidos , Estudantes , Universidades , Adulto Jovem
2.
Cogn Behav Neurol ; 26(4): 208-17, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24378606

RESUMO

OBJECTIVE: We introduce a novel test that allows pictorial, nonverbal assessment of action understanding. BACKGROUND: Focusing on action goals and the sequential nature of actions, the "Tomato and Tuna Test" tests whether exposure to the accomplished goal of an action is sufficient to infer the preceding action. This aspect has rarely been addressed in conventional paradigms. METHODS: We used the Tomato and Tuna Test in conjunction with another task, the Kissing and Dancing Test, to detect action understanding deficits in 11 patients (mean age 72 ± 6 years) with chronic brain lesions ± aphasia. We compared their performance to an age- and education-matched control group and to 15 young controls (mean age 24 ± 3 years). To investigate the influence of language deficits on test performance, we compared the scores of our patients with and without aphasia. RESULTS: Our patients were less accurate than the matched controls on the Tomato and Tuna Test, though not slower. The Kissing and Dancing Test did not differentiate between patients and matched controls. Young controls performed better than patients on both tests. CONCLUSIONS: We found no performance differences between our aphasic and nonaphasic patients, confirming our assumption that both tests measure action understanding without requiring intact language abilities. We recommend the "Tomato and Tuna Test" as a new nonverbal measure of action understanding that can reveal subtle deficits.


Assuntos
Afasia/psicologia , Compreensão , Testes Neuropsicológicos , Idoso , Animais , Afasia/diagnóstico , Estudos de Casos e Controles , Feminino , Humanos , Idioma , Solanum lycopersicum , Masculino , Atum
3.
Psychol Res ; 77(5): 659-69, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23007629

RESUMO

The present study investigates a possible memory advantage for solutions that were reached through insightful problem solving. We hypothesized that insight solutions (with Aha! experience) would be remembered better than noninsight solutions (without Aha! experience). 34 video clips of magic tricks were presented to 50 participants as a novel problem-solving task, asking them to find out how the trick was achieved. Upon discovering the solution, participants had to indicate whether they had experienced insight during the solving process. After a delay of 14 days, a recall of solutions was conducted. Overall, 55 % of previously solved tricks were recalled correctly. Comparing insight and noninsight solutions, 64.4 % of all insight solutions were recalled correctly, whereas only 52.4 % of all noninsight solutions were recalled correctly. We interpret this finding as a facilitating effect of previous insight experiences on the recall of solutions.


Assuntos
Rememoração Mental/fisiologia , Resolução de Problemas/fisiologia , Adulto , Conscientização/fisiologia , Criatividade , Feminino , Humanos , Masculino , Adulto Jovem
4.
J Intell ; 11(5)2023 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-37233335

RESUMO

Insight problems are likely to trigger an initial, incorrect mental representation, which needs to be restructured in order to find the solution. Despite the widespread theoretical assumption that this restructuring process happens suddenly, leading to the typical "Aha!" experience, the evidence is inconclusive. Among the reasons for this lack of clarity is that many measures of insight rely solely on the solvers' subjective experience of the solution process. In our previous paper, we used matchstick arithmetic problems to demonstrate that it is possible to objectively trace problem-solving processes by combining eye movements with new analytical and statistical approaches. Specifically, we divided the problem-solving process into ten (relative) temporal phases to better capture possible small changes in problem representation. Here, we go a step further to demonstrate that classical statistical procedures, such as ANOVA, cannot capture sudden representational change processes, which are typical for insight problems. Only nonlinear statistical models, such as generalized additive (mixed) models (GAMs) and change points analysis, correctly identified the abrupt representational change. Additionally, we demonstrate that explicit hints reorient participants' focus in a qualitatively different manner, changing the dynamics of restructuring in insight problem solving. While insight problems may indeed require a sudden restructuring of the initial mental representation, more sophisticated analytical and statistical approaches are necessary to uncover their true nature.

5.
J Vet Intern Med ; 24(5): 1203-10, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20673319

RESUMO

BACKGROUND: Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves. OBJECTIVE: To describe previously unreported kidney lesions and diagnostic test results in doxycycline-overdosed calves and to compare these results with other findings reported previously. ANIMALS: Thirty-two calves that presented with adverse effects after receiving high doses of doxycycline as a treatment for mild respiratory disorders. METHOD: Retrospective review of medical records. RESULTS: Clinical examination identified mainly lethargy, dyspnea, cough, tongue paresia or paralysis associated with dysphagia and sialorrhea, tachycardia, tachypnea, and signs of myopathy. Blood analysis indicated increases in creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and sorbitol dehydrogenase activities and increased serum creatinine and urea concentrations. ECG recordings and Doppler echocardiography examination identified ventricular premature beats and a decrease in left ventricular global and systolic function, respectively. Necropsy and histopathology disclosed necrosis of the myocardium, tongue, and some striated muscles, acute renal tubular necrosis, and fatty degeneration or congestion of the liver. CONCLUSIONS: Most of these findings corroborate previous observations made in doxycycline-overdosed calves, and further suggest myocardial and striated muscular toxicity as well as renal toxicity in doxycycline-overdosed calves.


Assuntos
Antibacterianos/administração & dosagem , Antibacterianos/efeitos adversos , Doenças dos Bovinos/induzido quimicamente , Doxiciclina/administração & dosagem , Doxiciclina/efeitos adversos , Animais , Bovinos , Doenças dos Bovinos/mortalidade , Relação Dose-Resposta a Droga , Overdose de Drogas , Feminino , Masculino , Músculo Esquelético/patologia , Miocárdio/patologia , Estudos Retrospectivos , Língua/patologia
6.
Cognition ; 205: 104411, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32762872

RESUMO

Prior research indicates that solutions accompanied by an Aha! experience are remembered better than those missing this feeling of epiphany. The question for the present studies was whether this insight memory advantage for problem solutions is modulated by the affective component of insight (the strong feelings that typically accompany the Aha! experience), or by the cognitive component (the restructuring or representational change that occurs during insightful problem solving). In both studies, participants viewed a set of magic trick videos to generate solutions for how each trick was done, and memory for the generated solutions was tested after a week delay. They also indicated the extent to which they experienced an Aha! moment at solution along with other perceptions of their experience. In the second study, they additionally rated the relevance of five action verbs for each trick (including one that implied the correct solution) multiple times during solution as a measure of restructuring the problem representation. The explanation for the insight memory advantage that was best supported by the results is that it is the joint consequence of finding correct solutions, the subjective feeling that one has found a correct solution (certainty), and experiencing an emotional pleasurable reaction during the problem solving process that all contribute to better memory for the solution. However, it did not seem to rely on having reached the solution via a sudden restructuring process.


Assuntos
Emoções , Resolução de Problemas , Humanos , Rememoração Mental , Gravação de Videoteipe
7.
J Vet Cardiol ; 31: 8-14, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32858392

RESUMO

A partial atrioventricular septal defect, represented as a large ostium primum atrial septal defect and common (bridging) atrioventricular valve leaflets with cleft septal leaflet of the mitral valve, was diagnosed incidentally in a nine-year-old warmblood gelding used for show jumping. Initial examination findings and a three-year follow-up are documented in this report. The horse was first presented for the evaluation of chronic coughing. A left-sided, grade 4/6 holosystolic (band-shaped) murmur was identified along with a similar right-sided, grade 3/6 heart murmur. Echocardiography revealed a 6.4 cm diameter communication in the ventral atrial septum, considered an ostium primum atrial septal defect, with bidirectional shunting. A hypertrophic septomarginal trabecula, a thickened tricuspid valve, a cleft septal leaflet of the mitral valve, moderate mitral and tricuspid regurgitation likely related to leaflet prolapse, mild aortic regurgitation, and signs of moderate right ventricular volume overload were found as well. Electrocardiography showed no arrhythmias neither at rest nor during treadmill exercise. The owner continued to use the horse for show jumping. No exercise intolerance or other signs of disease were noted. Follow-up examination was performed three years after initial presentation. Contrast echocardiography confirmed the presence of right-to-left shunting through the atrial septal defect. Compared with the initial examination, the left ventricular internal diameter on M-mode echocardiography had increased. Occasional ventricular premature depolarizations were noted on the resting and exercise electrocardiogram. This is the first description of a clinically asymptomatic partial atrioventricular septal defect in an adult sport horse.


Assuntos
Comunicação Interventricular/veterinária , Doenças dos Cavalos/diagnóstico , Condicionamento Físico Animal , Animais , Diagnóstico Diferencial , Ecocardiografia/veterinária , Comunicação Interventricular/diagnóstico por imagem , Doenças dos Cavalos/diagnóstico por imagem , Cavalos , Masculino
8.
AIMS Neurosci ; 6(2): 60-84, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32341969

RESUMO

Sometimes, the solution to a difficult problem simply pops into mind. Such a moment of sudden comprehension is known as "insight". This fundamental cognitive process is crucial for problem solving, creativity and innovation, yet its true nature remains elusive, despite one century of psychological research. Typically, insight is investigated by using spatial puzzles or verbal riddles. Broadening the traditional approach, we propose to tackle this question by presenting magic tricks to participants and asking them to find out the secret method used by the magician. Combining this approach with cueing in an fMRI experiment, we were able to break down the insight process into two underlying components: cognitive conflict and restructuring. During cognitive conflict, problem solvers identify incongruent information that does not match their current mental representation. In a second step this information is restructured, thereby allowing them to correctly determine how the magic trick was done. We manipulated the occurrence of cognitive conflict by presenting two types of cues that lead participants to either maintain their perceptual belief (congruent cue) or to change their perceptual belief (incongruent cue) for the mechanism behind the magic trick. We found that partially overlapping but distinct networks of brain activity were recruited for cognitive conflict and restructuring. Posterior, predominantly visual brain activity during cognitive conflict reflected processes related to prediction error, attention to the relevant cue-specific sensory domain, and the default brain state. Restructuring on the other hand, showed a highly distributed pattern of brain activity in regions of the default mode, executive control networks, and salience networks. The angular gyrus and middle temporal gyrus were active in both cognitive conflict and restructuring, suggesting that these regions are important throughout the insight problem solving process. We believe this type of approach towards understanding insight will give lead to a better understanding of this complex process and the specific role that different brain regions play in creative thought.

9.
Cogn Sci ; 43(8): e12771, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31446653

RESUMO

Insight problems are difficult because the initially activated knowledge hinders successful solving. The crucial information needed for a solution is often so far removed that gaining access to it through restructuring leads to the subjective experience of "Aha!". Although this assumption is shared by most insight theories, there is little empirical evidence for the connection between the necessity of restructuring an incorrect problem representation and the Aha! experience. Here, we demonstrate a rare case where previous knowledge facilitates the solving of insight problems but reduces the accompanying Aha! experience. Chess players were more successful than non-chess players at solving the mutilated checkerboard insight problem, which requires retrieval of chess-related information about the color of the squares. Their success came at a price, since they reported a diminished Aha! experience compared to controls. Chess players' problem-solving ability was confined to that particular problem, since they struggled to a similar degree to non-chess players to solve another insight problem (the eight-coin problem), which does not require chess-related information for a solution. Here, chess players and non-chess players experienced the same degree of insight.


Assuntos
Conhecimento , Resolução de Problemas , Logro , Adolescente , Adulto , Feminino , Humanos , Masculino , Adulto Jovem
10.
Equine Vet J ; 40(2): 185-8, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18267887

RESUMO

Polyneuritis equi (PNE) is a rare neurological disease in the horse. Because of the suspicion in PNE of a T-lymphocyte mediated immune response against the myelin, the objective of this study was to determine the composition of the inflammatory infiltrate in the involved nerves of 3 horses with PNE, studied retrospectively. T-lymphocytes were demonstrated in the lesions, which suggests a T-lymphocyte mediated immune response against myelin. In addition, the presence of B-lymphocytes indicated a local production of antibodies. More research, involving a prospective study, is needed to determine whether the T-lymphocytes are cytotoxic or T-helper lymphocytes.


Assuntos
Linfócitos B/imunologia , Cauda Equina , Doenças dos Cavalos/imunologia , Doenças do Sistema Nervoso Periférico/veterinária , Linfócitos T/imunologia , Animais , Feminino , Cavalos , Imuno-Histoquímica/veterinária , Masculino , Doenças do Sistema Nervoso Periférico/imunologia , Estudos Retrospectivos
11.
J Vet Intern Med ; 22(6): 1411-6, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19000251

RESUMO

BACKGROUND: Endocarditis is a rare heart condition with variable clinical expressions in equids. Risk factors for this disease are incompletely understood. OBJECTIVE: Describe risk factors for endocarditis in equids. ANIMALS: One hundred and fifty-three equids admitted to Liège University, 9 diagnosed with endocarditis and 144 free from endocarditis but admitted to the hospital with a differential diagnosis including this disease. METHODS: Retrospective case-control study. RESULTS: Equids with endocarditis were significantly younger (mean age = 4.84 +/- 5.74 years) than control equids (mean age = 10.8 +/- 7.73 years) (P = .01). No sex or breed predisposition was observed. Animals with hyperthermia (odds ratio [OR] = 24.4; confidence interval [CI] = 1.40-428), synovial distension (OR = 13.4; CI = 3.00-59.8), lameness (OR = 6.52; CI = 1.63-26.1), hyperglobulinemia (OR = 26.4; CI = 3.03-229), hypoalbuminemia (OR = 11.4; CI = 1.34-96.8), hyperfibrinogenemia (OR = 9.81; CI = 1.16-82.7), or leukocytosis (OR = 7.12; CI = 1.40-36.4) presented a significantly higher risk of having endocarditis than control horses. The presence of two of the clinical signs mentioned above significantly increased the probability of a diagnosis of endocarditis (P< or = .05). CONCLUSIONS AND CLINICAL IMPORTANCE: Age is associated with equine endocarditis. The diagnostic value of certain clinical signs and abnormalities in blood parameters in this disease are described.


Assuntos
Endocardite Bacteriana/veterinária , Equidae , Animais , Estudos de Casos e Controles , Endocardite Bacteriana/diagnóstico , Endocardite Bacteriana/patologia , Estudos Retrospectivos
12.
J Vet Pharmacol Ther ; 31(2): 108-16, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18307502

RESUMO

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy-terminal cross-linking telopeptide of type I collagen (CTX-1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX-1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX-1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX-1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses.


Assuntos
Conservadores da Densidade Óssea/farmacocinética , Remodelação Óssea/efeitos dos fármacos , Colágeno Tipo I/efeitos dos fármacos , Difosfonatos/farmacocinética , Cavalos/metabolismo , Animais , Área Sob a Curva , Conservadores da Densidade Óssea/administração & dosagem , Conservadores da Densidade Óssea/farmacologia , Química Farmacêutica , Colágeno Tipo I/sangue , Colágeno Tipo I/urina , Difosfonatos/administração & dosagem , Difosfonatos/sangue , Difosfonatos/farmacologia , Feminino , Infusões Intravenosas/veterinária , Injeções Intravenosas/veterinária , Masculino
13.
Tijdschr Diergeneeskd ; 133(12): 512-7, 2008 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-18615902

RESUMO

BACKGROUND: Few studies exist about factors affecting the outcome of horses with tetanus. ANIMALS: 31 equids (30 horses and 1 donkey) with a clinical diagnosis of tetanus admitted to the Equine Clinic of the University of Liege between 1991 and 2006. The cases were divided into two groups according to the outcome (survivors and non-survivors). METHODS: The clinical data of survivors and non-survivors were compared using an ANOVA (continuous data) or a Fisher's test (discrete data). RESULTS: The survival rate was 32%. Most animals were 5 years or younger, and none had been appropriately vaccinated. The non-survivors were significantly younger than the survivors. The development of dyspnoea, recumbency, and the combination of dysphagia, dyspnoea, and recumbency was observed significantly more in the non-survivors than in the survivors. The timing of tetanus antitoxin administration (either immediately after the onset of suggestive signs or after a delay) was not different between the two groups. The time between the occurrence of a wound and the first signs ranged from 2 days to 2 months and was not significantly different between groups. All non-survivors died within 8 days of the first signs. CONCLUSIONS & CLINICAL IMPORTANCE: This study suggests that young animals are affected more often and more severely by tetanus than older animals. Dyspnoea, recumbency, and the combination of dysphagia, dyspnoea, and recumbency can be considered as indicators of a poor prognosis in equids suffering from tetanus.


Assuntos
Equidae , Doenças dos Cavalos/mortalidade , Antitoxina Tetânica/uso terapêutico , Tétano/veterinária , Fatores Etários , Análise de Variância , Animais , Estudos de Casos e Controles , Feminino , Doenças dos Cavalos/tratamento farmacológico , Doenças dos Cavalos/patologia , Cavalos , Masculino , Países Baixos/epidemiologia , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Análise de Sobrevida , Tétano/tratamento farmacológico , Tétano/mortalidade , Tétano/patologia , Fatores de Tempo , Resultado do Tratamento
14.
J Vet Cardiol ; 20(1): 45-54, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29395940

RESUMO

OBJECTIVES: To assess the feasibility and repeatability of two-dimensional speckle tracking echocardiography for the evaluation of left ventricular function in healthy calves. ANIMALS: 12 Holstein calves, 62 ± 11.6 days old; 75.25 ± 5.4 Kg. METHODS: Observational study. Right parasternal short-axis views at papillary muscle level were recorded in standing calves and subsequently analyzed by two-dimensional speckle tracking for global and regional radial and circumferential strains and strain rates and radial displacement. Echocardiographic examinations were performed by 2 observers to evaluate intra- and interobserver repeatability and variability. RESULTS: Two-dimensional speckle tracking was feasible in all calves. Automated tracking was better in systole than in diastole. Repeatability of the technique was good in calves. Systolic radial strain and strain rate peak values showed little variability compared with systolic circumferential strain and strain rate and to all diastolic measurements. Variability of the interobserver measurements was greater than the intraobserver measurements. CONCLUSIONS: Two-dimensional speckle tracking is feasible in calves. As in other species, evaluation of systolic radial left ventricular function is more reliable than circumferential and diastolic left ventricular function.


Assuntos
Bovinos/fisiologia , Ecocardiografia/veterinária , Função Ventricular Esquerda , Animais , Estudos de Viabilidade , Feminino , Masculino , Reprodutibilidade dos Testes
15.
Front Hum Neurosci ; 12: 72, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29535620

RESUMO

During creative problem solving, initial solution attempts often fail because of self-imposed constraints that prevent us from thinking out of the box. In order to solve a problem successfully, the problem representation has to be restructured by combining elements of available knowledge in novel and creative ways. It has been suggested that sleep supports the reorganization of memory representations, ultimately aiding problem solving. In this study, we systematically tested the effect of sleep and time on problem solving, using classical insight tasks and magic tricks. Solving these tasks explicitly requires a restructuring of the problem representation and may be accompanied by a subjective feeling of insight. In two sessions, 77 participants had to solve classical insight problems and magic tricks. The two sessions either occurred consecutively or were spaced 3 h apart, with the time in between spent either sleeping or awake. We found that sleep affected neither general solution rates nor the number of solutions accompanied by sudden subjective insight. Our study thus adds to accumulating evidence that sleep does not provide an environment that facilitates the qualitative restructuring of memory representations and enables problem solving.

16.
Bone ; 41(3): 414-21, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17604709

RESUMO

INTRODUCTION: Tiludronate, a bisphosphonate, has recently been introduced in veterinary medicine to treat orthopedic conditions in the horse. This study was designed to evaluate its effects on biochemical biomarkers of bone metabolism and on bone density and structure in an experimental model of disuse osteoporosis induced by cast application in horses. METHODS: Two groups of eight horses were immobilized during 8 weeks. The first group (P-group) received a placebo, and the second group (T-group) received tiludronate 1 mg/kg by slow IV infusion. Both treatments were administered twice, 28 days apart. Immobilization consisted of stall rest with the left forelimb packed in a fiberglass cast. It was followed by a 4-week remobilization period and an 8-week standardized training protocol. One biomarker of bone resorption, the C-telopeptides of type I collagen cross-links (CTX-1) and one biomarker of bone formation, the bone isoenzyme of alkaline phosphatase (bone ALP), were assessed. Metacarpus III (MCIII) bone mineral density (BMD) and speed of sound (SOS) were evaluated respectively by dual energy X-ray absorptiometry (DEXA) and quantitative ultrasonography (QUS). Lameness was regularly assessed during the remobilization and training periods. Group- and time-related effects were tested by analysis of variance on repeated measurements. RESULTS: A rapid, transient and significant decrease in CTX-1 concentration was seen after each treatment in the T-group only. No significant differences between groups were seen in the evolution of bone ALP activity. At the end of the experiment, the loss of MCIII BMD measured by DEXA in the immobilized limb was significantly less in the T-group than in the P-group. The MCIII SOS measured by QUS did not significantly vary within or between groups throughout the study. DISCUSSION AND CONCLUSIONS: Tiludronate was found to significantly reduce bone resorption during immobilization, as well as to prevent long-term osteopenia in the immobilized limb. Disuse osteopenia did not affect the lateral superficial cortex of MCIII.


Assuntos
Conservadores da Densidade Óssea/farmacologia , Doenças Ósseas Metabólicas/prevenção & controle , Remodelação Óssea/efeitos dos fármacos , Osso e Ossos/efeitos dos fármacos , Difosfonatos/farmacologia , Absorciometria de Fóton , Fosfatase Alcalina/sangue , Fosfatase Alcalina/efeitos dos fármacos , Animais , Densidade Óssea/efeitos dos fármacos , Colágeno Tipo I/sangue , Colágeno Tipo I/efeitos dos fármacos , Cavalos , Masculino , Peptídeos/sangue , Peptídeos/efeitos dos fármacos , Restrição Física
17.
Equine Vet J ; 39(1): 26-32, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17228591

RESUMO

REASONS FOR PERFORMING STUDY: There is a lack of well documented studies about muscular lesions in equine atypical myopathy (EAM). OBJECTIVES: To characterise morphopathological changes of striated muscles and myocardium, to progress understanding of this disease. METHODS: Thirty-two horses age 0.5-7 years kept on pasture were referred for a sudden ataxia/myoglobinuria syndrome. Clinical examination (stiffness, muscle pain, muscle fasciculations, abnormal gait, recumbency, myoglobinuria, tachycardia, sweating) and plasma CPK, LDH and AST levels were consistent with extensive myonecrosis and, together with anamnestic data, with so-called 'equine atypical myopathy' (EAM), a disease of unknown aetiology reported since 1939. Macroscopic and microscopic (histology, histoenzymology, ultrastructure) lesions were evaluated. RESULTS: Necropsic examination revealed large areas of muscle necrosis, the extent and severity of which varied between cases and muscles, but which were clearly more constant and severe in respiratory and postural muscles and in the myocardium. Histology highlighted a multifocal and monophasic process compatible with Zenker degeneration/necrosis that mostly and segmentally affected type 1 fibres. Histochemical evaluation revealed a weak and disorganised pattern of NADH tetrazolium reductase staining, the absence of calcium salts precipitates and a dramatic accumulation of lipid droplets. Ultrastructural examination often revealed fibres of which the sole modifications were altered mitochondria and sarcoplasmic lipidosis. CONCLUSIONS: Taken together, the data suggest that a primary alteration of mitochondria should be considered, although secondary mitochondrial abnormalities have yet to be ruled out. POTENTIAL RELEVANCE: The morphological features gathered here reveal that EAM shares most of the characteristics of toxic myopathies.


Assuntos
Doenças dos Cavalos/metabolismo , Mitocôndrias Cardíacas/metabolismo , Mitocôndrias Musculares/metabolismo , Músculo Esquelético/metabolismo , Rabdomiólise/veterinária , Animais , Feminino , Doenças dos Cavalos/patologia , Cavalos , Masculino , Mitocôndrias Cardíacas/patologia , Mitocôndrias Cardíacas/ultraestrutura , Mitocôndrias Musculares/patologia , Mitocôndrias Musculares/ultraestrutura , Necrose/veterinária , Oxirredução , Rabdomiólise/metabolismo , Rabdomiólise/patologia
18.
J Vet Cardiol ; 19(6): 492-501, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29111285

RESUMO

INTRODUCTION: The aim of this study was to establish echocardiographic reference values for the equine species using allometric regression equations based on body weight (BW) and thoracic circumference (TC). ANIMALS: A total of 239 horses or ponies were studied, including 65 warmbloods, 33 Standardbreds, 41 Thoroughbreds, 32 Arabian horses, 28 draft horses, and 40 ponies aged from 1 day to 30 years, weighing from 18 to 890 kg, with no evidence of cardiac disease. METHODS: For each horse or pony, a two-dimensional and M-mode echocardiography was performed. Within each breed, the relationships between BW or TC and echocardiographic dimensions were examined using power regression equations. Predictions and their 95% prediction intervals were calculated for the echocardiographic measurements. RESULTS: Within each breed, all echocardiographic measurements showed a significant and positive relationship with a high coefficient of determination for the estimation of the regression equations using BW and TC as the main explanatory variables. Breed-specific power regression equations as well as the 95% prediction intervals were calculated for each echocardiographic measurement as a function of BW and TC. CONCLUSIONS: In the future, the body size-corrected and breed-specific echocardiographic reference values calculated in the present study could be used to discriminate between normal and abnormal values in a given animal.


Assuntos
Ecocardiografia/veterinária , Coração/diagnóstico por imagem , Cavalos/fisiologia , Animais , Tamanho Corporal , Feminino , Coração/fisiologia , Masculino , Linhagem , Valores de Referência
19.
Equine Vet J ; 38(1): 47-51, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16411586

RESUMO

REASONS FOR PERFORMING STUDY: Equine motor neuron disease (EMND) was diagnosed in 3 horses maintained on lush, grass-based pasture. This contrasted with North American studies which identified limited or no access to green herbage as an important risk factor for EMND. HYPOTHESIS: Grazing horses that have an apparently adequate intake of pasture herbage to meet normal equine vitamin E requirements can develop EMND. METHODS: Owners of 32 European horses diagnosed with EMND completed a questionnaire regarding intrinsic, managemental, nutritional and environmental factors that could potentially be risk factors for EMND, and also regarding clinical signs, treatments and case outcome. Plasma/serum vitamin E data for these horses were supplied by the veterinarians. No control population was studied. RESULTS: Thirteen of 32 horses (termed the 'grazing' group) had part- or full-time access to grass-based pasture at the onset of EMND (median duration at pasture 12 h/day, range 3-24 h). Five of these horses were at pasture for at least 235 h/day at the onset of EMND, 2 of which were at pasture for at least 23.5 h/day throughout the year. Despite grazing, all these horses had a low vitamin E status. The remaining 19 horses resembled those cases reported from North America, in that they had no or limited access to pasture. CONCLUSIONS AND POTENTIAL RELEVANCE: A diagnosis of EMND should not be discounted on the basis that a horse has access, even full-time, to lush grass-based pasture. Inadequate vitamin E intake was probably not the sole cause of either the EMND or the low vitamin E status in the grazing horses; the latter was probably the result of abnormal bioavailability or excessive utilisation of vitamin E.


Assuntos
Fenômenos Fisiológicos da Nutrição Animal , Doenças dos Cavalos/etiologia , Doença dos Neurônios Motores/veterinária , Poaceae , Vitamina E , Ração Animal , Animais , Disponibilidade Biológica , Cruzamento , Meio Ambiente , Feminino , Doenças dos Cavalos/sangue , Cavalos , Masculino , Doença dos Neurônios Motores/sangue , Doença dos Neurônios Motores/etiologia , Necessidades Nutricionais , Estado Nutricional , Fatores de Risco , Inquéritos e Questionários , Vitamina E/administração & dosagem , Vitamina E/sangue , Deficiência de Vitamina E/sangue , Deficiência de Vitamina E/complicações , Deficiência de Vitamina E/veterinária , Vitaminas/administração & dosagem , Vitaminas/sangue
20.
Front Psychol ; 7: 2077, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-28163687

RESUMO

The subjective Aha! experience that problem solvers often report when they find a solution has been taken as a marker for insight. If Aha! is closely linked to insightful solution processes, then theoretically, an Aha! should only be experienced when the correct solution is found. However, little work has explored whether the Aha! experience can also accompany incorrect solutions ("false insights"). Similarly, although the Aha! experience is not a unitary construct, little work has explored the different dimensions that have been proposed as its constituents. To address these gaps in the literature, 70 participants were presented with a set of difficult problems (37 magic tricks), and rated each of their solutions for Aha! as well as with regard to Suddenness in the emergence of the solution, Certainty of being correct, Surprise, Pleasure, Relief, and Drive. Solution times were also used as predictors for the Aha! EXPERIENCE: This study reports three main findings: First, false insights exist. Second, the Aha! experience is multidimensional and consists of the key components Pleasure, Suddenness and Certainty. Third, although Aha! experiences for correct and incorrect solutions share these three common dimensions, they are also experienced differently with regard to magnitude and quality, with correct solutions emerging faster, leading to stronger Aha! experiences, and higher ratings of Pleasure, Suddenness, and Certainty. Solution correctness proffered a slightly different emotional coloring to the Aha! experience, with the additional perception of Relief for correct solutions, and Surprise for incorrect ones. These results cast some doubt on the assumption that the occurrence of an Aha! experience can serve as a definitive signal that a true insight has taken place. On the other hand, the quantitative and qualitative differences in the experience of correct and incorrect solutions demonstrate that the Aha! experience is not a mere epiphenomenon. Strong Aha! experiences are clearly, but not exclusively linked to correct solutions.

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