Early Caregiver Predictability Shapes Neural Indices of Statistical Learning Later in Infancy.

Caregivers play an outsized role in shaping early life experiences and development, but we often lack mechanistic insight into how exactly caregiver behavior scaffolds the neurodevelopment of specific learning processes. Here, we capitalized on the fact that caregivers differ in how predictable their behavior is to ask if infants' early environmental input shapes their brains' later ability to learn about predictable information. As part of an ongoing longitudinal study in South Africa, we recorded naturalistic, dyadic interactions between 103 (46 females and 57 males) infants and their primary caregivers at 3-6 months of age, from which we calculated the predictability of caregivers' behavior, following caregiver vocalization and overall. When the same infants were 6-12-months-old they participated in an auditory statistical learning task during EEG. We found evidence of learning-related change in infants' neural responses to predictable information during the statistical learning task. The magnitude of statistical learning-related change in infants' EEG responses was associated with the predictability of their caregiver's vocalizations several months earlier, such that infants with more predictable caregiver vocalization patterns showed more evidence of statistical learning later in the first year of life. These results suggest that early experiences with caregiver predictability influence learning, providing support for the hypothesis that the neurodevelopment of core learning and memory systems is closely tied to infants' experiences during key developmental windows.

Visual and cognitive processes contribute to age-related improvements in visual selective attention.

Children (N = 103, 4-9 years, 59 females, 84% White, c. 2019) completed visual processing, visual feature integration (color, luminance, motion), and visual search tasks. Contrast sensitivity and feature search improved with age similarly for luminance and color-defined targets. Incidental feature integration improved more with age for color-motion than luminance-motion. Individual differences in feature search ( ß = .11) and incidental feature integration ( ß = .06) mediated age-related changes in conjunction visual search, an index of visual selective attention. These findings suggest that visual selective attention is best conceptualized as a series of developmental trajectories, within an individual, that vary by an object's defining features. These data have implications for design of educational and interventional strategies intended to maximize attention for learning and memory.

Pandemic beyond the virus: maternal COVID-related postnatal stress is associated with infant temperament.

BACKGROUND: Studies have shown that infant temperament varies with maternal psychosocial factors, in utero illness, and environmental stressors. We predicted that the pandemic would shape infant temperament through maternal SARS-CoV-2 infection during pregnancy and/or maternal postnatal stress. To test this, we examined associations among infant temperament, maternal prenatal SARS-CoV-2 infection, maternal postnatal stress, and postnatal COVID-related life disruptions. METHODS: We tested 63 mother-infant dyads with prenatal maternal SARS-CoV-2 infections and a comparable group of 110 dyads without infections. To assess postnatal maternal stress, mothers completed the Perceived Stress Scale 4 months postpartum and an evaluation of COVID-related stress and life disruptions 6 months postpartum. Mothers reported on infant temperament when infants were 6-months-old using the Infant Behavior Questionnaire-Revised (IBQ-R) Very Short Form. RESULTS: Maternal SARS-CoV-2 infection during pregnancy was not associated with infant temperament or maternal postnatal stress. Mothers with higher self-reported postnatal stress rated their infants lower on the Positive Affectivity/Surgency and Orienting/Regulation IBQ-R subscales. Mothers who reported greater COVID-related life disruptions rated their infants higher on the Negative Emotionality IBQ-R subscale. CONCLUSIONS: Despite no effect of prenatal maternal SARS-CoV-2 infection, stress and life disruptions incurred by the COVID-19 pandemic were associated with infant temperament at 6-months. IMPACT: SARS-CoV-2 infection during pregnancy is not associated with postnatal ratings of COVID-related life disruptions, maternal stress, or infant temperament. Postnatal ratings of maternal stress during the COVID-19 pandemic are associated with normative variation in maternal report of infant temperament at 6 months of age. Higher postnatal ratings of maternal stress are associated with lower scores on infant Positive Affectivity/Surgency and Orienting/Regulation at 6 months of age. Higher postnatal ratings of COVID-related life disruptions are associated with higher scores on infant Negative Emotionality at 6 months of age.

The Ecological Resilience Framework: The Justice Ambassadors Youth Council as a model for community-based resilience.

We present an 'Ecological Resilience Framework' (ERF) to demonstrate how resilience is created through the Justice Ambassadors Youth Council (JAYC) program. JAYC is a platform in which New York government representatives collaboratively learn and develop policy solutions alongside emerging adults who are criminal legal system impacted and reside in predominantly Black and Hispanic communities characterized by chronically high levels of poverty, violence, and incarceration. We focus our work on the process of developing resilience in the context of structural social inequity and injustice. We argue that resilience can best be understood in the context of the adversity to which it is a response, not as an isolated individual quality. Therefore, resilience science is at its best when it incorporates a multi-disciplinary scientific perspective, one that addresses a continuum from individual- to community- to society-level physical, cognitive, relationship, and mental health variables. To demonstrate how our ERF incorporates this approach, we outline how JAYC not only supports young adult participants in understanding their individual life trajectories and narrative identity, but also actively connects them within a diverse social network of mentors and to various opportunities that support a healthy transition to adult resilience.

Infants use contextual memory to attend and learn in naturalistic scenes.

Infants encounter new objects and learn about object features in relation to a rich and detailed visuospatial context. Using a contextual cueing task, recent work showed that 6- and 10-month-old infants search more efficiently for target objects in repeated rather than novel visuospatial contexts (i.e., arrays of shapes on a blank background). Here, we investigate whether infants' sensitivity to visuospatial context scales up to more complex and potentially more distracting, naturalistic scenes. In an eye-tracking task, 8-month-olds searched for a novel target object in colorful photographs of everyday environments (e.g., bedrooms and kitchens). Repeated ("Old") contexts co-varied with target locations, such that the target object appeared in exactly the same location on the same scene, while varying ("New") contexts contained target objects placed in different counterbalanced locations across a variety of scenes. Infants exhibited faster search times, more anticipation of target animation, and longer looking at targets that appeared in Old relative to New contexts. In a subsequent memory test, infants showed better recognition of label-object pairings for target objects that had appeared in Old, rather than New, contexts. These results indicate that infants can use visuospatial contextual information in complex naturalistic scenes to facilitate memory-guided attention and learning of object-paired labels.

The Ontogeny of Hippocampus-Dependent Memories.

The formation of memories that contain information about the specific time and place of acquisition, which are commonly referred to as "autobiographical" or "episodic" memories, critically relies on the hippocampus and on a series of interconnected structures located in the medial temporal lobe of the mammalian brain. The observation that adults retain very few of these memories from the first years of their life has fueled a long-standing debate on whether infants can make the types of memories that in adults are processed by the hippocampus-dependent memory system, and whether the hippocampus is involved in learning and memory processes early in life. Recent evidence shows that, even at a time when its circuitry is not yet mature, the infant hippocampus is able to produce long-lasting memories. However, the ability to acquire and store such memories relies on molecular pathways and network-based activity dynamics different from the adult system, which mature with age. The mechanisms underlying the formation of hippocampus-dependent memories during infancy, and the role that experience exerts in promoting the maturation of the hippocampus-dependent memory system, remain to be understood. In this review, we discuss recent advances in our understanding of the ontogeny and the biological correlates of hippocampus-dependent memories.

All contexts are not created equal: Social stimuli win the competition for organizing reinforcement learning in 9-month-old infants.

Previous work has shown that infants as young as 8 months of age can use certain features of the environment, such as the shape or color of visual stimuli, as cues to organize simple inputs into hierarchical rule structures, a robust form of reinforcement learning that supports generalization of prior learning to new contexts. However, especially in cluttered naturalistic environments, there are an abundance of potential cues that can be used to structure learning into hierarchical rule structures. It is unclear how infants determine what features constitute a higher-order context to organize inputs into hierarchical rule structures. Here, we examine whether 9-month-old infants are biased to use social stimuli, relative to non-social stimuli, as a higher-order context to organize learning of simple visuospatial inputs into hierarchical rule sets. Infants were presented with four face/color-target location pairings, which could be learned most simply as individual associations. Alternatively, infants could use the faces or colorful backgrounds as a higher-order context to organize the inputs into simpler color-location or face-location rules, respectively. Infants were then given a generalization test designed to probe how they learned the initial pairings. The results indicated that infants appeared to use the faces as a higher-order context to organize simpler color-location rules, which then supported generalization of learning to new face contexts. These findings provide new evidence that infants are biased to organize reinforcement learning around social stimuli.

The value of proactive goal setting and choice in 3- to 7-year-olds' use of working memory gating strategies in a naturalistic task.

Rule-guided behavior depends on the ability to strategically update and act on content held in working memory. Proactive and reactive control strategies were contrasted across two experiments using an adapted input/output gating paradigm (Neuron, 81, 2014 and 930). Behavioral accuracies of 3-, 5-, and 7-year-olds were higher when a contextual cue appeared at the beginning of the task (input gating) rather than at the end (output gating). This finding supports prior work in older children, suggesting that children are better when input gating but rely on the more effortful output gating strategy for goal-oriented action selection (Cognition, 155, 2016 and 8). A manipulation was added to investigate whether children's use of working memory strategies becomes more flexible when task goals are specified internally rather than externally provided by the experimenter. A shift toward more proactive control was observed when children chose the task goal among two alternatives. Scan path analyses of saccadic eye movement indicated that giving children agency and choice over the task goal resulted in less use of a reactive strategy than when the goal was determined by the experimenter.

The attentive brain: insights from developmental cognitive neuroscience.

Visual attention functions as a filter to select environmental information for learning and memory, making it the first step in the eventual cascade of thought and action systems. Here, we review studies of typical and atypical visual attention development and explain how they offer insights into the mechanisms of adult visual attention. We detail interactions between visual processing and visual attention, as well as the contribution of visual attention to memory. Finally, we discuss genetic mechanisms underlying attention disorders and how attention may be modified by training.

What underlies visual selective attention development? Evidence that age-related improvements in visual feature integration influence visual selective attention performance.

Visual selective attention (VSA) improves across childhood. Conjunction search tasks require integrating multiple visual features in order to find a target among distractors and are often used to measure VSA. Motivated by the visual system's architecture and developmental changes in neural connectivity, we predicted that feature integration across separate visual pathways (e.g., color and motion) should develop later than feature integration within the same visual pathways (e.g., luminance and motion). A total of 89 4- to 10-year-old children completed a visual search task that manipulated whether feature integration was between separate parallel visual pathways or within the same visual pathway. We first examined whether color-motion integration was associated with a performance cost relative to luminance-motion integration across childhood. We found that color-motion integration was worse than luminance-motion integration in early childhood but that this difference decreased with age. We also examined whether luminance-motion and color-motion visual search performance developed differently across childhood. Reaction time (RT) visual search slopes for the luminance-motion condition were both stable across childhood and steeper overall than those for the color-motion condition. In contrast, RT search slopes for the color-motion condition became steeperincrease across childhood. Finally, we found that age-related improvements in color-motion integration, relative to luminance-motion integration, were associated with longer color-motion search rates across childhood. These data suggest that age-related improvements in color-motion feature integration may increase competition between color-motion targets and distractors, thereby increasing the amount of time needed to process distractors as nontargets during the selection process.

Adaptive rule learning of event sequences during the A-not-B task in 9-month-old infants.

Prior work indicates that infants can use social information to organize simple audiovisual inputs into predictable rules by 8 months of age. However, it is unclear whether infants can use social information to organize more complex events into predictable rules that can be used to guide motor action. To examine these issues, we tested 9-month-old infants using a modified version of an A-not-B task, in which hiding event sequences were paired with different experimenters, who could be used to organize the events into rules that guide action. We predicted that infants' reaching accuracy would be better when the experimenter changes when the toy's hiding location changes, relative to when the experimenter stays the same, as this should cue a novel rule used to guide action. Experiments 1 and 2 validated this prediction. Experiment 3 showed that reaching accuracy was better when the toy's hiding location switched but was consistent with the rule associated with the experimenter, relative to when the toy's hiding location repeated but was inconsistent with the rule associated with the experimenter. These data suggest that infants can use the identities of experimenters to organize events into predictable rules that guide action in the A-not-B task.

The relationship between cognitive enrichment and cognitive control: A systematic investigation of environmental influences on development through socioeconomic status.

We measured the impact of socioeconomic status (SES) on cognitive processes. We examined cognitive control, specifically working memory (WM), in a sample of N = 141 7- to 17-year-olds using rule-guided behavior tasks. Our hypothesis is based on computational modeling data that suggest that the development of flexible cognitive control requires variable experiences in which to implement rule-guided action. We found that not all experiences that correlated with SES in our sample impacted task performance, and not all experiential variables that impacted performance were associated with SES. Of the experiential variables associated with task performance, only cognitive enrichment opportunities worked indirectly through SES to affect WM as tested with rule-guided behavior tasks. We discuss the data in the context of necessary precision in SES research.

The emergence of object-based visual attention in infancy: A role for family socioeconomic status and competing visual features.

The development of spatial visual attention has been extensively studied in infants, but far less is known about the emergence of object-based visual attention. We tested 3-5- and 9-12-month-old infants on a task that allowed us to measure infants' attention orienting bias toward whole objects when they competed with color, motion, and orientation feature information. Infants' attention orienting to whole objects was affected by the dimension of the competing visual feature. Whether attention was biased toward the whole object or its salient competing feature (e.g., "ball" or "red") changed with age for the color feature, with infants biased toward whole objects with age. Moreover, family socioeconomic status predicted feature-based attention in the youngest infants and object-based attention in the older infants when color feature information competed with whole-object information.

Top-down contextual knowledge guides visual attention in infancy.

The visual context in which an object or face resides can provide useful top-down information for guiding attention orienting, object recognition, and visual search. Although infants have demonstrated sensitivity to covariation in spatial arrays, it is presently unclear whether they can use rapidly acquired contextual knowledge to guide attention during visual search. In this eye-tracking experiment, 6- and 10-month-old infants searched for a target face hidden among colorful distracter shapes. Targets appeared in Old or New visual contexts, depending on whether the visual search arrays (defined by the spatial configuration, shape and color of component items in the search display) were repeated or newly generated throughout the experiment. Targets in Old contexts appeared in the same location within the same configuration, such that context covaried with target location. Both 6- and 10-month-olds successfully distinguished between Old and New contexts, exhibiting faster search times, fewer looks at distracters, and more anticipation of targets when contexts repeated. This initial demonstration of contextual cueing effects in infants indicates that they can use top-down information to facilitate orienting during memory-guided visual search.

Role of Prefrontal Cortex in Learning and Generalizing Hierarchical Rules in 8-Month-Old Infants.

Recent research indicates that adults and infants spontaneously create and generalize hierarchical rule sets during incidental learning. Computational models and empirical data suggest that, in adults, this process is supported by circuits linking prefrontal cortex (PFC) with striatum and their modulation by dopamine, but the neural circuits supporting this form of learning in infants are largely unknown. We used near-infrared spectroscopy to record PFC activity in 8-month-old human infants during a simple audiovisual hierarchical-rule-learning task. Behavioral results confirmed that infants adopted hierarchical rule sets to learn and generalize spoken object-label mappings across different speaker contexts. Infants had increased activity over right dorsal lateral PFC when rule sets switched from one trial to the next, a neural marker related to updating rule sets into working memory in the adult literature. Infants' eye blink rate, a possible physiological correlate of striatal dopamine activity, also increased when rule sets switched from one trial to the next. Moreover, the increase in right dorsolateral PFC activity in conjunction with eye blink rate also predicted infants' generalization ability, providing exploratory evidence for frontostriatal involvement during learning. These findings provide evidence that PFC is involved in rudimentary hierarchical rule learning in 8-month-old infants, an ability that was previously thought to emerge later in life in concert with PFC maturation. SIGNIFICANCE STATEMENT: Hierarchical rule learning is a powerful learning mechanism that allows rules to be selected in a context-appropriate fashion and transferred or reused in novel contexts. Data from computational models and adults suggests that this learning mechanism is supported by dopamine-innervated interactions between prefrontal cortex (PFC) and striatum. Here, we provide evidence that PFC also supports hierarchical rule learning during infancy, challenging the current dogma that PFC is an underdeveloped brain system until adolescence. These results add new insights into the neurobiological mechanisms available to support learning and generalization in very early postnatal life, providing evidence that PFC and the frontostriatal circuitry are involved in organizing learning and behavior earlier in life than previously known.

Across space and time: infants learn from backward and forward visual statistics.

This study investigates whether infants are sensitive to backward and forward transitional probabilities within temporal and spatial visual streams. Two groups of 8-month-old infants were familiarized with an artificial grammar of shapes, comprising backward and forward base pairs (i.e. two shapes linked by strong backward or forward transitional probability) and part-pairs (i.e. two shapes with weak transitional probabilities in both directions). One group viewed the continuous visual stream as a temporal sequence, while the other group viewed the same stream as a spatial array. Following familiarization, infants looked longer at test trials containing part-pairs than base pairs, although they had appeared with equal frequency during familiarization. This pattern of looking time was evident for both forward and backward pairs, in both the temporal and spatial conditions. Further, differences in looking time to part-pairs that were consistent or inconsistent with the predictive direction of the base pairs (forward or backward) indicated that infants were indeed sensitive to direction when presented with temporal sequences, but not when presented with spatial arrays. These results suggest that visual statistical learning is flexible in infancy and depends on the nature of visual input.

The effects of emotion priming on visual search in socially anxious adults.

This study examined the effects of emotion priming on visual search in participants characterised for different levels of social anxiety. Participants were primed with five facial emotions (angry, fear, happy, neutral, and surprised) and one scrambled face immediately prior to visual search trials involving finding a slanted coloured line amongst distractors, as reaction times and accuracy to target detection were recorded. Results suggest that for individuals low in social anxiety, being primed with an angry, surprised, or fearful face facilitated visual search compared to being primed with scrambled, neutral or happy faces. However, these same emotions degraded visual search in participants with high levels of social anxiety. This study expands on previous research on the impact of emotion on attention, finding that amongst socially anxious individuals, the effects of priming with threat extend beyond initial attention capture or disengagement, degrading later visual search.

Visual selective attention biases contribute to the other-race effect among 9-month-old infants.

During the first year of life, infants maintain their ability to discriminate faces from their own race but become less able to differentiate other-race faces. Though this is likely due to daily experience with own-race faces, the mechanisms linking repeated exposure to optimal face processing remain unclear. One possibility is that frequent experience with own-race faces generates a selective attention bias to these faces. Selective attention elicits enhancement of attended information and suppression of distraction to improve visual processing of attended objects. Thus attention biases to own-race faces may boost processing and discrimination of these faces relative to other-race faces. We used a spatial cueing task to bias attention to own- or other-race faces among Caucasian 9-month-old infants. Infants discriminated faces in the focus of the attention bias, regardless of race, indicating that infants remained sensitive to differences among other-race faces. Instead, efficacy of face discrimination reflected the extent of attention engagement.

Perception, as you make it.

The main question that Firestone & Scholl (F&S) pose is whether "what and how we see is functionally independent from what and how we think, know, desire, act, and so forth" (sect. 2, para. 1). We synthesize a collection of concerns from an interdisciplinary set of coauthors regarding F&S's assumptions and appeals to intuition, resulting in their treatment of visual perception as context-free.

Not all attention orienting is created equal: recognition memory is enhanced when attention orienting involves distractor suppression.

Learning through visual exploration often requires orienting of attention to meaningful information in a cluttered world. Previous work has shown that attention modulates visual cortex activity, with enhanced activity for attended targets and suppressed activity for competing inputs, thus enhancing the visual experience. Here we examined the idea that learning may be engaged differentially with variations in attention orienting mechanisms that drive eye movements during visual search and exploration. We hypothesized that attention orienting mechanisms that engaged suppression of a previously attended location would boost memory encoding of the currently attended target objects to a greater extent than those that involve target enhancement alone. To test this hypothesis we capitalized on the classic spatial cueing task and the inhibition of return (IOR) mechanism (Posner, 1980; Posner, Rafal, & Choate, 1985) to demonstrate that object images encoded in the context of concurrent suppression at a previously attended location were encoded more effectively and remembered better than those encoded without concurrent suppression. Furthermore, fMRI analyses revealed that this memory benefit was driven by attention modulation of visual cortex activity, as increased suppression of the previously attended location in visual cortex during target object encoding predicted better subsequent recognition memory performance. These results suggest that not all attention orienting impacts learning and memory equally.