Detalhe da pesquisa
1.
The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human ß1-Adrenoceptor.
Mol Pharmacol
; 103(2): 89-99, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351797
2.
Asthma and COPD: A Focus on ß-Agonists - Past, Present and Future.
Handb Exp Pharmacol
; 2023 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37709918
3.
Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy.
Mol Pharmacol
; 96(6): 851-861, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31624135
4.
Novel selective ß1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.
FASEB J
; 31(7): 3150-3166, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400472
5.
ß-Blockers, heart disease and COPD: current controversies and uncertainties.
Thorax
; 72(3): 271-276, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27927840
6.
The structural basis for agonist and partial agonist action on a ß(1)-adrenergic receptor.
Nature
; 469(7329): 241-4, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21228877
7.
Negative cooperativity across ß1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 ß1-adrenoceptor binding conformation.
FASEB J
; 29(7): 2859-71, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25837585
8.
Salmeterol's extreme ß2 selectivity is due to residues in both extracellular loops and transmembrane domains.
Mol Pharmacol
; 87(1): 103-20, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25324048
9.
Case for continuing community NIV and CPAP during the COVID-19 epidemic.
Thorax
; 75(5): 368, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32273336
10.
Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human ß1-adrenoceptor.
Mol Pharmacol
; 85(5): 811-29, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24608857
11.
Structure of a beta1-adrenergic G-protein-coupled receptor.
Nature
; 454(7203): 486-91, 2008 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18594507
12.
Rational design, synthesis, and pharmacological evaluation of a cohort of novel beta-adrenergic receptors ligands enables an assessment of structure-activity relationships.
Eur J Med Chem
; 246: 114961, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36495629
13.
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Br J Pharmacol
; 180 Suppl 2: S23-S144, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123151
14.
Predicting in vivo cardiovascular properties of ß-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
FASEB J
; 25(12): 4486-97, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21865315
15.
The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and ß-adrenoceptors.
Pharmacol Res Perspect
; 10(2): e00936, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35224877
16.
The signaling and selectivity of α-adrenoceptor agonists for the human α2A, α2B and α2C-adrenoceptors and comparison with human α1 and ß-adrenoceptors.
Pharmacol Res Perspect
; 10(5): e01003, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36101495
17.
The selectivity of α-adrenoceptor agonists for the human α1A, α1B, and α1D-adrenoceptors.
Pharmacol Res Perspect
; 9(4): e00799, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355529
18.
Fragment evolution for GPCRs: the role of secondary binding sites in optimization.
Chem Commun (Camb)
; 57(81): 10516-10519, 2021 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34550124
19.
Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients.
Eur J Cancer
; 147: 106-116, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33639323
20.
The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors.
Pharmacol Res Perspect
; 8(4): e00602, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32608144