1.
J Org Chem
; 84(7): 3887-3903, 2019 04 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30862161
RESUMO
We here describe the use of three-component reactions to synthesize tricyclic pyridine ring-fused 2-pyridones. The developed protocols have a wide substrate scope and allow for the installation of diverse chemical functionalities on the tricyclic central fragment. Several of these pyridine-fused rigid polyheterocycles are shown to bind to Aß and α-synuclein fibrils, which are associated with neurodegenerative diseases.