Detalhe da pesquisa
1.
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Antimicrob Agents Chemother
; 66(4): e0219221, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266826
2.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
3.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
4.
Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents.
Xenobiotica
; 47(1): 31-49, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27122100
5.
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc Natl Acad Sci U S A
; 111(46): 16274-9, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25368144
6.
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
J Biol Chem
; 290(34): 20984-20994, 2015 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26149691
7.
In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.
Antimicrob Agents Chemother
; 59(1): 467-74, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25385112
8.
In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase.
Xenobiotica
; 45(2): 158-70, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25142218
9.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
10.
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase.
ACS Infect Dis
; 9(3): 706-715, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802491
11.
Anti-infectives Developed as Racemic Drugs in the 21st Century: Norm or Exception?
ACS Med Chem Lett
; 14(7): 875-878, 2023 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37465315
12.
A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria.
Macromol Biosci
; 23(5): e2200518, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999404
13.
Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty.
Bioorg Med Chem Lett
; 22(17): 5600-7, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22877632
14.
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
J Med Chem
; 65(4): 3371-3387, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35113565
15.
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
J Med Chem
; 65(9): 6903-6925, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500229
16.
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
J Med Chem
; 64(1): 719-740, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33395287
17.
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
J Med Chem
; 64(17): 12790-12807, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34414766
18.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
19.
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.
ACS Infect Dis
; 6(11): 3048-3063, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32966036
20.
Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
J Med Chem
; 63(20): 11882-11901, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32914979