Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Tipo de documento
Ano de publicação
Intervalo de ano de publicação
1.
Bioanalysis ; 15(15): 905-914, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37354101

RESUMO

Background: Workplace drug testing primarily relies on urine analysis, targeting multiple compounds with varying physicochemical characteristics. Biocompatible solid-phase microextraction (BioSPME) is a miniaturized solid-phase extraction technique that enables the simultaneous extraction and preconcentration of analytes directly from the biological matrix. Methods: The BioSPME procedure consisted of the sequential extraction of 50-µl urine samples using LC Tips C18 in basic and acidic pH, followed by desorption with methanol and n-hexane, respectively. The extracts were analyzed by ultra-performance LC-MS/MS. Results: Intra-day precision was 1.2-8.6% and inter-day precision was 1.8-14.2%. Accuracy was 96.8-107.4%. The extraction yields were 62.8-109.4%. The matrix effects were -3.98% to 1%. Conclusion: BioSPME shows promise as an alternative method for preparing urine samples prior to drug measurement by ultra-performance LC-MS/MS.


Assuntos
Cocaína , Dronabinol , Cromatografia Líquida/métodos , Cocaína/análise , Analgésicos Opioides , Espectrometria de Massas em Tandem/métodos , Extração em Fase Sólida , Anfetaminas/análise , Cromatografia Líquida de Alta Pressão/métodos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA