Pesquisa | Biblioteca Virtual em Saúde Fiocruz

1.

Translational Pharmacology of PRAX-944, a Novel T-Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor.

Scott, Liam; Puryear, Corey B; Belfort, Gabriel M; Raines, Shane; Hughes, Zoë A; Matthews, Lillian G; Ravina, Bernard; Wittmann, Marion.

Mov Disord ; 37(6): 1193-1201, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35257414

2.

High-performance genetically targetable optical neural silencing by light-driven proton pumps.

Chow, Brian Y; Han, Xue; Dobry, Allison S; Qian, Xiaofeng; Chuong, Amy S; Li, Mingjie; Henninger, Michael A; Belfort, Gabriel M; Lin, Yingxi; Monahan, Patrick E; Boyden, Edward S.

Nature ; 463(7277): 98-102, 2010 Jan 07.

Artigo em Inglês | MEDLINE | ID: mdl-20054397

3.

The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.

Paul, Steven M; Doherty, James J; Robichaud, Albert J; Belfort, Gabriel M; Chow, Brian Y; Hammond, Rebecca S; Crawford, Devon C; Linsenbardt, Andrew J; Shu, Hong-Jin; Izumi, Yukitoshi; Mennerick, Steven J; Zorumski, Charles F.

J Neurosci ; 33(44): 17290-300, 2013 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-24174662

4.

Synchrony 2022: Roundtable Discussion on the Pathways and the Challenges of Getting Medications FDA Approved.

Belfort, Gabriel; Nanda, Heer; Slattery, John C; Sambor, Joanna; Rodakis, John; Frye, Richard E.

J Pers Med ; 13(5)2023 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-37240949

5.

T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.

Matthews, Lillian G; Puryear, Corey B; Correia, Susana S; Srinivasan, Sharan; Belfort, Gabriel M; Pan, Ming-Kai; Kuo, Sheng-Han.

Ann Clin Transl Neurol ; 10(4): 462-483, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36738196

6.

Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.

Bakirtzi, Kyriaki; Belfort, Gabriel; Lopez-Coviella, Ignacio; Kuruppu, Darshini; Cao, Lei; Abel, E Dale; Brownell, Anna-Liisa; Kandror, Konstantin V.

J Neurosci ; 29(16): 5193-201, 2009 Apr 22.

Artigo em Inglês | MEDLINE | ID: mdl-19386915

7.

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA_A receptor positive allosteric modulator.

Althaus, Alison L; Ackley, Michael A; Belfort, Gabriel M; Gee, Steven M; Dai, Jing; Nguyen, David P; Kazdoba, Tatiana M; Modgil, Amit; Davies, Paul A; Moss, Stephen J; Salituro, Francesco G; Hoffmann, Ethan; Hammond, Rebecca S; Robichaud, Albert J; Quirk, Michael C; Doherty, James J.

Neuropharmacology ; 181: 108333, 2020 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-32976892

8.

Neuroactive Steroids. 2. 3α-Hydroxy-3ß-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5ß-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (Î³-Aminobutyric Acid)_A Receptor.

Martinez Botella, Gabriel; Salituro, Francesco G; Harrison, Boyd L; Beresis, Richard T; Bai, Zhu; Blanco, Maria-Jesus; Belfort, Gabriel M; Dai, Jing; Loya, Carlos M; Ackley, Michael A; Althaus, Alison L; Grossman, Scott J; Hoffmann, Ethan; Doherty, James J; Robichaud, Albert J.

J Med Chem ; 60(18): 7810-7819, 2017 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-28753313

9.

Neuroactive Steroids. 1. Positive Allosteric Modulators of the (Î³-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21.

Martinez Botella, Gabriel; Salituro, Francesco G; Harrison, Boyd L; Beresis, Richard T; Bai, Zhu; Shen, Kaisheng; Belfort, Gabriel M; Loya, Carlos M; Ackley, Michael A; Grossman, Scott J; Hoffmann, Ethan; Jia, Shiling; Wang, Jiamiao; Doherty, James J; Robichaud, Albert J.

J Med Chem ; 58(8): 3500-11, 2015 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-25799373

10.

Npas4 regulates a transcriptional program in CA3 required for contextual memory formation.

Ramamoorthi, Kartik; Fropf, Robin; Belfort, Gabriel M; Fitzmaurice, Helen L; McKinney, Ross M; Neve, Rachael L; Otto, Tim; Lin, Yingxi.

Science ; 334(6063): 1669-75, 2011 Dec 23.

Artigo em Inglês | MEDLINE | ID: mdl-22194569

11.

Cellugyrin induces biogenesis of synaptic-like microvesicles in PC12 cells.

Belfort, Gabriel M; Bakirtzi, Kyriaki; Kandror, Konstantin V.

J Biol Chem ; 280(8): 7262-72, 2005 Feb 25.

Artigo em Inglês | MEDLINE | ID: mdl-15590695

12.

Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells.

Belfort, Gabriel M; Kandror, Konstantin V.

J Biol Chem ; 278(48): 47971-8, 2003 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-12928441

13.

Mother knows best.

Belfort, Gabriel M.

Nature ; 420(6913): 268, 2002 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-12447417

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