Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 36
Filtrar
1.
Molecules ; 29(9)2024 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-38731641

RESUMO

With accelerated advancements in various industries, water pollution has emerged as a significant issue characterized by two features: (1) the rapid increase in population and corresponding demands, leading to a sharp rise in wastewater discharge, and (2) the development of new technologies, contributing to a significant increase in the variety of emerging contaminants, resulting in a more complex wastewater composition [...].

2.
Molecules ; 29(10)2024 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-38792046

RESUMO

In response to the need for improvement in the utilization of ammonium-rich solutions after the electrochemical reduction of nitrate (NO3--RR), this study combined phosphorus-containing wastewater and adopted the electrochemical precipitation method for the preparation of struvite (MAP) to simultaneously recover nitrogen and phosphorus resources. At a current density of 5 mA·cm-2 and an initial solution pH of 7.0, the recovery efficiencies for nitrogen and phosphorus can reach 47.15% and 88.66%, respectively. Under various experimental conditions, the generated struvite (MgNH4PO4·6H2O) exhibits a typical long prismatic structure. In solutions containing nitrate and nitrite, the coexisting ions have no significant effect on the final product, struvite. Finally, the characterization of the precipitate product by X-ray diffraction (XRD) revealed that its main component is struvite, with a high purity reaching 93.24%. Overall, this system can effectively recover ammonium nitrogen from the NO3--RR solution system after nitrate reduction, with certain application prospects for the recovery of ammonium nitrogen and phosphate.

3.
J Environ Sci (China) ; 142: 21-32, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38527886

RESUMO

In the context of carbon capture, utilization, and storage, the high-value utilization of carbon storage presents a significant challenge. To address this challenge, this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na2CO3 products using simulated seawater concentrate, achieving simultaneous saline wastewater utilization, carbon storage and high-value production of Na2CO3. The effects of various factors, including concentration of simulated seawater concentrate, current density, CO2 aeration rate, and circulating flow rate of alkali chamber, on the quality of Na2CO3 product, carbon sequestration rate, and energy consumption were investigated. Under the optimal condition, the CO32- concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol% purity. The resulting carbon fixation rate was 70.50%, with energy consumption for carbon sequestration and product production of 5.7 kWhr/m3 CO2 and 1237.8 kWhr/ton Na2CO3, respectively. This coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.


Assuntos
Dióxido de Carbono , Carbono , Carbonatos , Água do Mar , Sódio
4.
BMC Surg ; 23(1): 142, 2023 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-37231385

RESUMO

BACKGROUND: The Parkland Grading Scale (PGS) is an intraoperative grading scale to stratify gallbladder disease severity during laparoscopic cholecystectomy (LC). We evaluated the usefulness of the PGS in predicting the difficulty levels of LC procedures using a novel approach. METHODS: A total of 261 patients diagnosed with cholelithiasis and cholecystitis who underwent LC were assessed. The PGS and the surgical difficulty grading system were used to evaluate surgical procedures by reviewing the operation videos. Clinical baseline characteristics and post-treatment outcomes were also recorded. Differences between the five PGS grades in terms of surgical difficulty scores were analyzed using the Jonckheere-Terpstra test. The relationship between PGS grades and surgical difficulty scores was assessed using Spearman's Rank correlation. Finally, the linear trends between morbidity scores and PGS grades were evaluated using the Mantel-Haenszel test. RESULTS: There was a significant difference in the surgical difficulty scores for the five PGS grades (p < 0.001). In pairwise comparison, each grade (1-5) was significantly different from the others (p < 0.05) in terms of surgical difficulty, except Grade 2 vs. 3 (p = 0.07) and Grade 3 vs. 4 (p = 0.08). There was a significant correlation between PGS grades and surgical difficulty scores (rs = 0.681, p < 0.001). There was also a significant linear association between morbidity and PGS grades (p < 0.001). Spearman's R value was 0.176 (p = 0.004). CONCLUSION: The PGS can accurately assess the surgical difficulty level of LC. The precision and conciseness of the PGS make it suitable for use in future research.


Assuntos
Colecistectomia Laparoscópica , Colecistite , Doenças da Vesícula Biliar , Humanos , Colecistectomia Laparoscópica/métodos , Colecistite/diagnóstico , Duração da Cirurgia , Doenças da Vesícula Biliar/cirurgia
5.
BMC Surg ; 23(1): 277, 2023 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-37704959

RESUMO

BACKGROUND: Percutaneous transhepatic gallbladder drainage (PTGBD) is a relatively less invasive alternative treatment to cholecystostomy. However, the influence of the difficulty of delayed laparoscopic cholecystectomy (DLC) after PTGBD on clinical outcomes remains unknown. This study aimed to evaluate the clinical effects of DLC following PTGBD. METHODS: The clinical data of 113 patients diagnosed with moderate (grade II) acute cholecystitis according to the 2018 Tokyo Guidelines in the acute phase and who underwent DLC in our hospital from January 2018 to February 2022 were retrospectively collected and separated into two groups according to whether they received PTGBD treatment in the acute stage. The PTGBD group comprised 27 cases, and the no-PTGBD group included 86 cases. The TG18 difficulty score was used to evaluate every surgical procedure in the cases by reviewing the surgical videos. The clinical baseline characteristics and post-treatment outcomes were also evaluated. RESULTS: Both groups showed significant differences in length of postoperative stay, blood loss, operation time, and difficulty score. The PTGBD group showed a significantly longer postoperative stay and operation time, more blood loss, and a much higher difficulty score than the no-PTGBD group. Conversion rates did not differ. The morbidity rate in the PTGBD group was statistically higher. CONCLUSIONS: PTGBD is an efficient way to relieve the symptoms of acute cholecystitis. However, it may increase the difficulty and complications of DLC.


Assuntos
Colecistectomia Laparoscópica , Colecistite Aguda , Colecistostomia , Humanos , Estudos Retrospectivos , Colecistectomia Laparoscópica/efeitos adversos , Colecistite Aguda/cirurgia , Drenagem
6.
Molecules ; 28(4)2023 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-36838610

RESUMO

The discharge of saline wastewater has significantly increased due to rapid urbanization and industrialization [...].


Assuntos
Urbanização , Águas Residuárias , Desenvolvimento Industrial , Tecnologia
7.
Molecules ; 28(2)2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36677780

RESUMO

In this paper, methyl glycine diacetic acid (MGDA) was found to have great influence on the morphology and particle size of barium sulfate. The effects of additive, concentration, value of pH and reaction temperature on the morphology and particle size of barium sulfate were studied in detail. The results show that the concentration of reactant and temperature have little effect on the particle size of barium sulfate. However, the pH conditions of the solution and the dosage of MGDA can apparently affect the particle size distribution of barium sulfate. The particle size of barium sulfate particles increases and the morphology changes from polyhedral to rice-shaped with the decreasing of the dosage of MGDA. In solution with higher pH, smaller and rice-shaped barium sulfate was obtained. To investigate the interacting mechanism of MGDA, the binding energy between MGDA and barium sulfate surface was calculated. It was found that the larger absolute value of the binding energy would result in stronger growth inhibition on the crystal face. Finally, the experimental data and theoretical calculations were combined to elucidate the interacting mechanism of the additive on the morphology and particle size of barium sulfate.


Assuntos
Sulfato de Bário , Sulfato de Bário/química , Sulfato de Bário/metabolismo , Tamanho da Partícula , Temperatura , Propriedades de Superfície
8.
Water Sci Technol ; 88(5): 1317-1331, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37771229

RESUMO

Selective electrodialysis is a promising approach to recovering K+ from complex coexisting ionic systems. In this study, the effects of current density, the concentration of K+ and Mg2+, as well as the operating temperature on the separation process of K+ and Mg2+ were explored to investigate the competitive migration of mono- and multivalent ions, offering a guide for the design of selective electrodialysis process, and therefore obtain the desired aqueous solutions containing K+ and Mg2+. The results show that ion concentration played a critical role in determining the selectivity of separation between K+ and Mg2+. High concentrations of K+ and Mg2+ led to a decrease in selectivity but the effect of concentration of K+ on selectivity was more pronounced. Although higher current density increased the flux of ions, their impact on separation selectivity was minimal. Furthermore, higher temperature increased the flux of ions but resulted in a decrease of K+ proportion in the solution. Overall, this study provides good guidance for studying the competitive migration of mono- and multivalent ions and the high-value recycling of potassium resources.

9.
BMC Emerg Med ; 22(1): 170, 2022 10 24.
Artigo em Inglês | MEDLINE | ID: mdl-36280806

RESUMO

BACKGROUND: Acute appendicitis is the most common cause of acute abdomen. During the pandemic, to contain the spread of COVID-19, there were some integral changes in the medical processes based on the pandemic prevention policy, especially regarding emergency surgery. This study was conducted to investigate whether this pandemic also impacted the decision-making for both patients and medical personnel along with the treatment outcomes. METHODS: Patients of age 18 years or older who were diagnosed clinically and radiologically with acute appendicitis between Jan 1, 2017, and Dec 31, 202,0 were reviewed. The data of 1991 cases were collected and used for this study. Two groups were formed, one group before and the other group after the outbreak. The gathered data included gender, age, appendiceal fecalith, outcomes of treatment, and long-term outcomes of non-operation (8 months follow-up). We also collected details of surgical cases from the above two groups. This data also included age, gender, appendiceal fecalith, fever, jaundice, length of onset before presenting to an emergency department (ED), anesthesia, surgery, white cell count, pathology, complications, and length of stay. We compared the above data respectively and analyzed the differences. RESULTS: Compared to the period before the outbreak, patient visits for acute appendicitis remarkably dropped (19.8%), but surgical cases showed no change (dropped by roughly 5%). There were significant differences (P < 0.05) in failure of non-operation(after the pandemic 8.31% vs. before pandemic 3.22%), interval appendectomy(after pandemic 6.29% vs. before pandemic 12.84%), recurrence(after pandemic 23.27% vs. before pandemic 14.46%), and outcomes of recurrence. There was a significant difference (P < 0.05) in anesthesia method, surgery way, and complications( before pandemic 4.15% vs. after pandemic9.89% P < 0.05) in patients who underwent the surgery. There was no statistical difference (P > 0.05) concerning age, gender, fever, jaundice, appendiceal fecalith, white cell count, and length of onset before presenting to the ED. CONCLUSION: The current pandemic prevention policy is very effective, but some decision-making processes of doctor-patient have changed in the context of COVID-19 pandemic, that further influenced some treatment outcomes and might lead to a potential economic burden. It is essential to address the undue concern of everyone and optimize the treatment process.


Assuntos
Apendicite , COVID-19 , Impacção Fecal , Humanos , Lactente , Adolescente , Apendicite/epidemiologia , Apendicite/cirurgia , Apendicite/diagnóstico , COVID-19/epidemiologia , Pandemias , Impacção Fecal/epidemiologia , Apendicectomia/métodos , Doença Aguda , Estudos Retrospectivos , Tempo de Internação
10.
Molecules ; 27(17)2022 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-36080342

RESUMO

The microstructure of a mixed KCl and K2SO4 aqueous solution was studied using X-ray scattering (XRS), Raman spectroscopy, and molecular dynamics simulation (MD). Reduced structure functions [F(Q)], reduced pair distribution functions [G(r)], Raman spectrum, and pair distribution functions (PDF) were obtained. The XRS results show that the main peak (r = 2.81 Å) of G(r) shifted to the right of the axis (r = 3.15 Å) with increased KCl and decreased K2SO4. The main peak was at r = 3.15 Å when the KCl concentration was 26.00% and the K2SO4 concentration was 0.00%. It is speculated that this phenomenon was caused by the main interaction changing, from K-OW (r = 2.80 Å) and OW-OW (r = 2.80 Å), to Cl−-OW (r = 3.14 Å) and K+-Cl− (r = 3.15 Å). According to the trend of the hydrogen bond structure in the Raman spectrum, when the concentration of KCl was high and K2SO4 was low, the destruction of the tetrahedral hydrogen bond network in the solution was more serious. This shows that the destruction strength of the anion to the hydrogen bond network structure in solution was Cl− > SO42−. In the MD simulations, the coordination number of OW-OW decreased with increasing KCl concentration, indicating that the tetrahedral hydrogen bond network was severely disrupted, which confirmed the results of the Raman spectroscopy. The hydration radius and coordination number of SO42− in the mixed solution were larger than Cl−, thus revealing the reason why the solubility of KCl in water was greater than that of K2SO4 at room temperature.


Assuntos
Simulação de Dinâmica Molecular , Análise Espectral Raman , Análise Espectral Raman/métodos , Sulfatos , Água/química , Raios X
11.
Med Sci Monit ; 27: e928719, 2021 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-33611335

RESUMO

BACKGROUND Balance dysfunction is common in adult outpatients with dizziness, especially those who are older, which can lead to catastrophic outcomes such as falls. The aim of this study was to investigate the association between chronic conditions and balance disorders in patients with dizziness, especially those who are elderly. MATERIAL AND METHODS A cross-sectional study was conducted in adult outpatients diagnosed with dizziness referred to the Department of Otolaryngology at Beijing Tongren Hospital from September 2017 to August 2018. All of the patients completed a self-administered, structured questionnaire. Demographic data and information on history of chronic conditions were collected and the patients were divided into 2 groups based on whether their balance was normal or abnormal. RESULTS Three hundred and thirty-two patients were included in this study, 168 in the normal balance group and 164 in the abnormal balance group. The incidence of chronic conditions, including hypertension and diabetes, in the abnormal balance group was higher than that in the normal balance group (all P<0.05). In subgroup analysis based on age, in those who were aged ≥60 years, the prevalence of chronic diseases was higher in the abnormal balance group than in the normal balance group (P=0.002), while there was no difference in age between the groups with abnormal and normal balance. Hypertension (OR: 2.268; 95%CI: 1.038-4.957; P<0.05) was a risk factor for balance disorders in elderly patients rather than those who were younger (P>0.05). CONCLUSIONS Our results show that chronic conditions are associated with balance function in older patients with dizziness. Thus, specialists should consider chronic conditions, especially hypertension, in elderly patients with dizziness.


Assuntos
Doença Crônica/epidemiologia , Tontura/fisiopatologia , Equilíbrio Postural/fisiologia , Acidentes por Quedas , Idoso , Estudos Transversais , Tontura/etiologia , Feminino , Hospitais , Humanos , Masculino , Pessoa de Meia-Idade , Pacientes Ambulatoriais , Prevalência , Fatores de Risco , Inquéritos e Questionários , Vertigem
12.
J Phys Chem B ; 128(1): 208-221, 2024 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-38113228

RESUMO

Aqueous solutions of magnesium chloride (MgCl2(aq)) are often used to test advances in the theory of electrolyte solutions because they are considered an ideal strong 2:1 electrolyte. However, there is evidence that some ion association occurs in these solutions, even at low concentrations. Even a small ion-pairing constant can have a significant impact on the chemical speciation of ions, so it is important to determine whether ion pairing actually occurs. In this study, MgCl2(aq) with concentrations ranging from 1 to 35% was studied using three methods: X-ray scattering (XRS) with the Shanghai Synchrotron Radiation Facility (SSRF) and silver-anode laboratory sources, Raman spectroscopy, and molecular dynamics (MD) simulations with the COMPASS-II and Madrid force fields. XRS results were analyzed in the framework of PDF theory to obtain the reduced structure function F(Q) and the reduced pair distribution function G(r). The F(Q) values from synchrotron radiation and laboratory sources both showed that the tetrahedral hydrogen bonds in bulk water were destroyed with the increased MgCl2 concentration. The results of G(r) indicated that the main peaks centered at 2.05 and 2.80 Å can be ascribed to the interactions of Mg-O and O-O, respectively. The peak at 3.10 Å is attributed to the combined effect of O-O and Cl-O. By comparing the structural information on MgCl2 solution obtained from the two light sources, it was found that both SSRF and silver-anode laboratory sources can reflect the above-mentioned structural information on MgCl2 solution. The radial distribution function (RDF) obtained from MD simulations of MgCl2 solutions assigned the peaks at 2.0, 2.8, and 3.2 Å to the Mg-O, O-O, and Cl-O interatomic pairs, respectively. The decrease in the O-O coordination number confirms that the hydrogen-bonding network of water is disrupted by increasing MgCl2 observed by X-ray scattering. The proportion of Mg-Cl contact ion pairs gradually increases with MgCl2 concentration as does the coordination number. Raman spectroscopy results show that the bond type changes from double donor double acceptor (DDAA) to single donor-single acceptor (DA) with increasing concentration, providing explicit details of the hydrogen-bond evolution in the aqueous solution.

13.
Sci Total Environ ; 904: 166949, 2023 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-37696408

RESUMO

The treatment of wastewater has become increasingly challenging as a result of its growing complexity. To achieve synergistic removal of coexisting pollutants in wastewater, one promising approach involves the integration of electric fields. We conducted a comprehensive literature review to explore the potential of integrating electric fields and developing efficient electro-intensified simultaneous decontamination systems for wastewater containing coexisting pollutants. The review focused on comprehending the applications and mechanisms of these systems, with a particular emphasis on the deliberate utilization of positive and negative charges. After analyzing the advantages, disadvantages, and application efficacy of these systems, we observed electro-intensified systems exhibit flexible potential through their rational combination, allowing for an expanded range of applications in addressing simultaneous decontamination challenges. Unlike the reviews focusing on single elimination, this work aims to provide guidance in addressing the environmental problems resulting from the coexistence of hazardous contaminants.

14.
World J Clin Cases ; 10(30): 11037-11043, 2022 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-36338216

RESUMO

BACKGROUND: Alimentary tract duplication (ATD) is a rare congenital anomaly. Thus, a case of ATD with a complete colonic duplication isolated in the abdominal cavity with a fistula and multiple malformations is very distinctive. These characteristics show the variability of this disease and explain why it tends to be challenging to diagnose and treat. CASE SUMMARY: A 25-year-old woman with a history of a fistula opening in her right hip since birth presented with the irregular discharge of foul fluid from the fistula and intermittent abdominal pain. Contrast-enhanced computed tomography and magnetic resonance imaging findings revealed a duplicated tube isolated in her abdominal pelvic cavity along with a pelvic malformation and double ureter. Right foot radiographic examination showed pes cavus. During surgery, the tube appeared to be an almost complete colonic structure and was verified to be connected to the fistula. All of the involved tissue and fistula were removed, and the defect in the pelvic floor was closed by suturing after surgery. After 8 mo, the postoperative follow-up has been uneventful. CONCLUSION: ATD may be a differential diagnosis in sinus tract cases. Laparoscopy combined with open surgery is a viable treatment option.

15.
Water Res ; 226: 119274, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36332296

RESUMO

With the development of comprehensive utilization of high-salinity wastewater, salt resources regeneration has been considered as the fundamental requirement for process sustainability and economic benefits. As one of the potential candidates, bipolar membrane electrodialysis (BMED) was rapidly developed in recent years for the treatment of saline wastewater. Different from other methods directly obtaining salts or condensed wastewater, BMED could utilize and convert the dissolved waste salt into higher-value acid and alkali simultaneously, which has various advantages including outstanding environmental effects and economic benefits. In this review, the recent applications of BMED for waste salt recovery and high-value acid/alkali generation from saline wastewater were systematically outlined. Based on the summary above, the economy analysis of BMED was further reviewed from the roles of desalination and resources recovery. In addition, the BMED-based processes integrated with in-situ utilization of the generated acid/alkali resources were discussed. Furthermore, the influence of operating factors on BMED performance were outlined. Finally, the strategies for improving BMED performance were concluded. Furthermore, the future application and prospects of BMED was presented. This work would provide guidance for the applications of bipolar membrane electrodialysis in saline wastewater treatment and the high-value conversion of salt resources into acids and alkalis.


Assuntos
Águas Residuárias , Purificação da Água , Álcalis , Membranas Artificiais , Purificação da Água/métodos , Membranas , Cloreto de Sódio
16.
ACS Omega ; 7(21): 17811-17821, 2022 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-35664623

RESUMO

Iron- and cobalt-based heterogeneous catalysts are widely applied for activating peroxymonosulfate (PMS) to degrade organic pollutants. However, few studies have unveiled the clear synergistic mechanism of iron and cobalt in ZSM-5. In this paper, the synergistic mechanism of enhanced PMS activation was revealed by constructing iron and cobalt bimetal modified ZSM-5 zeolite catalysts (FeCo-ZSM-5). The tetracycline hydrochloride (TCH) degradation experiments showed that the catalytic activity of FeCo-ZSM-5-2:3 was much higher than those of Fe-ZSM-5 and Co-ZSM-5. In addition, the influences of catalyst dosage, PMS concentration, reaction temperature, initial pH, and coexisting ions on TCH removal were systematically investigated in this paper. Density functional theory calculations indicated that Co was the main active site for PMS adsorption, and Fe increased the area of Co's positive potential mapped to the electron cloud. The Fe-Co bimetallic doping increased the area of positive potential mapped to the electron cloud and benefited the adsorption of PMS on the catalyst surface, which revealed the synergistic mechanism of bimetals. Electron paramagnetic resonance spectra and quenching experiments showed that sulfate radicals, singlet oxygen, and hydroxyl radicals were involved in the degradation of TCH. Furthermore, liquid chromatography-mass spectrometry was conducted to propose possible degradation pathways. This work provides certain guiding significance in understanding the synergistic effect of heterogeneous catalysts for tetracycline wastewater treatment.

17.
Sci Total Environ ; 820: 153272, 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35074375

RESUMO

Carbon dioxide (CO2) capture coupled with further mineralization in high value-added form is a great challenge for carbon capture utilization and storage (CCUS) processes. In this work, a bipolar membrane electrodialysis (BMED) technique integrated with crystallization chamber was proposed to utilize CO2-derived carbonates and the residual magnesium resource from seawater to produce functional nesquehonite. To ensure the stable CO2 storage and magnesium extraction by BMED process, the metastable zone during nesquehonite crystallizing was first measured to modulate crystallization rate, obtain high-quality crystal products and inhibit membrane fouling states. Subsequently, the effects of current density, temperature, and CO2 flow rate during the whole BMED-crystallization process were further investigated. The increase in current density and temperature was conducive for the extraction of magnesium while the enlarged gas flow rate induced higher absorption of CO2. Under the current density at 22 A/m2, CO2 flow rate at 50 mL/min and temperature at 30 °C, the optimal carbon absorption ratio and the magnesium extraction ratio reached 50.85% and 56.71%, respectively. Under this condition, the explosion nucleation of the nesquehonite was effectively avoided to inhibit membrane fouling and the generation of magnesium hydroxide was depressed to obtain the target product nesquehonite. This study on simultaneous carbon capture and magnesium utilization provides theoretical guidance for the industrial green storage of CO2 and development of valuable magnesium products.


Assuntos
Dióxido de Carbono , Magnésio , Dióxido de Carbono/química , Carbonatos , Magnésio/química , Água do Mar/química , Temperatura
18.
J Investig Med ; 70(6): 1392-1398, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35318276

RESUMO

To explore the molecular pathogenesis of primary hyperparathyroidism (PHPT), we investigated the proliferation and apoptosis of parathyroid cells in a rabbit model of diet-induced PHPT. A total of 120 adult Chinese rabbits were randomly divided into normal diet (Ca:P, 1:0.7) group (control group) or a high-phosphate diet (Ca:P, 1:7) group (experimental group). The thyroid and parathyroid complexes were harvested for 1-month interval from month 1 to month 6. The expression of proliferation markers, including proliferating cell nuclear antigen (PCNA) and cyclin-D1, and B cell lymphoma-2 (Bcl-2), were evaluated by immunohistochemistry in thyroid and parathyroid tissues. Apoptosis was quantified by DNA-fragment terminal labeling. Our results demonstrated that parathyroid cells in the experimental group started proliferating from the end of the 2nd month, the expression of PCNA, Bcl-2, and cyclin-D1 were significantly higher in the PHPT group than those of the control group (p<0.05). Furthermore, the apoptosis index (AI) was positively correlated with the glandular cell count and expression of PCNA in the 6th month in the PHPT group. Overall, our results suggested that excessive proliferation and apoptosis of parathyroid cells may contribute to the pathogenesis of PHPT through PCNA-related, Bcl-2-related, and cyclin-D1-related pathways.


Assuntos
Hiperparatireoidismo Primário , Animais , Apoptose , Proliferação de Células , Hiperparatireoidismo Primário/metabolismo , Antígeno Nuclear de Célula em Proliferação/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2 , Coelhos
19.
Otol Neurotol ; 42(6): e744-e749, 2021 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-33606471

RESUMO

OBJECTIVE: To investigate the correlation between benign paroxysmal positional vertigo (BPPV) and abnormal bone metabolism and to evaluate the value of otoconial protein otoconin-90 in the pathogenesis research and clinical treatment of BPPV. STUDY DESIGN: Prospective pilot clinical trial (Level of Evidence: 2b). SETTING: Outpatient otolaryngologic department. PATIENTS: Twenty seven patients with a diagnosis of BPPV referred to the otolaryngologic department and 25 controls with no history of dizziness from 2018.4 to 2018.9 were reviewed. INTERVENTIONS: No. MAIN OUTCOME MEASURES: Dual-energy x-ray absorptiometry scanning (DEXA), bone mineral density (BMD) measurement, and assessment of serum levels of otoconin-90 and bone metabolism indices (osteocalcin, OC; 25-OH Vitamin D; total procollagen type 1 N-peptide, TP1NP; ß-C-terminal telopeptide of type 1 collagen, ß-CTX). RESULTS: 1) The average serum level of otoconin-90 in the BPPV group was significantly higher than that in the control group (p < 0.05), whereas both the BMD T scores and serum 25-OH Vitamin D levels of the BPPV group were significantly lower than those of the control group (p < 0.05). 2) There was a strong positive correlation between serum otoconin-90 and age (r = 0.44, p < 0.05) and a moderate negative correlation between otoconin-90 and the bone metabolism indices OC (r = -0.33, p > 0.05), 25-OH Vitamin D (r = -0.35, p > 0.05), and TP1NP (r = -0.30, p > 0.05). 3) Logistic regression analysis showed that serum otoconin-90 level was an independent risk factor for BPPV (odd ratio = 0.998, 95% confidence interval 0.997-0.999, p < 0.01). CONCLUSION: A correlation between BPPV and abnormal bone metabolism was found. Moreover, otoconin-90 could serve as a research tool for BPPV.


Assuntos
Vertigem Posicional Paroxística Benigna , Deficiência de Vitamina D , Densidade Óssea , Humanos , Estudos Prospectivos , Vitamina D
20.
Chemosphere ; 263: 127889, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32828053

RESUMO

Fe2O3 and its composites have been extensively investigated and employed for the remediation of contaminated water with the characteristics of low cost, outstanding chemical stability, high efficiency of visible light utilization, excellent magnetic ability and abundant active sites for adsorption and degradation. In this review, the potentials of Fe2O3 in water remediation were discussed and summarized in detail. Firstly, various synthesis methods of Fe2O3 and its composites were reviewed and compared. Based on the structures and characteristics of the obtained materials, their applications and related mechanisms in pollutants removal were surveyed and discussed. Furthermore, several strategies for optimizing the remediation processes, including dispersion, immobilization, nano/micromotor construction and simultaneous decontamination, were also highlighted and discussed. Finally, recommendations for further work in the development of novel Fe2O3-related materials and its practical applications were proposed.


Assuntos
Eliminação de Resíduos Líquidos/métodos , Poluentes Químicos da Água/química , Adsorção , Compostos Férricos/química , Águas Residuárias/química , Água , Poluentes Químicos da Água/análise , Purificação da Água/métodos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA