Detalhe da pesquisa
1.
Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening.
J Enzyme Inhib Med Chem
; 35(1): 1137-1144, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32367744
2.
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.
Bioorg Med Chem
; 18(10): 3506-17, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413313
3.
Synthetic applications of polystyrene-supported 1,1,3,3-tetramethylguanidine.
Comb Chem High Throughput Screen
; 11(10): 843-7, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19075606
4.
4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action.
J Med Chem
; 50(16): 3945-53, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17629262
5.
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.
J Med Chem
; 49(26): 7826-35, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181165
6.
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.
J Med Chem
; 49(17): 5363-71, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913726
7.
Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.
ACS Med Chem Lett
; 4(11): 1031-6, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900602
8.
Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors.
J Enzyme Inhib Med Chem
; 22(3): 309-18, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17674813
9.
4-Amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: Synthesis, SARs, and preliminary studies on the mechanism of action.
Bioorg Med Chem
; 15(16): 5563-75, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17548197