INTERACTION BETWEEN NATURAL POLYPHENOL RESVERATROL AND IMMUNE SYSTEM: BIOCHEMICAL ASPECTS.

The article explains the biochemical aspects of interaction of natural polyphenol resveratrol and immune system. The molecular mechanisms of action of resveratrol are given. The anti-inflammatory effect of resveratrol is described in detail. The relationship between resveratrol and tumor macrophages was analyzed. It has been shown that resveratrol can have an activating, suppressive and modeling effect on the cells of immune system, as well as exhibit a suppressive effect on inflammatory and tumor processes.

MOLECULAR EFFECTS OF RESVERATROL IN THE TREATMENT OF AUTOIMMUNE DISEASES.

The article represents the molecular effect of resveratrol on the course and progression of autoimmune processes. It has been shown that resveratrol in a low dose inhibits the formation and activity of some B-lymphocytes subpopulations. On the one hand, this leads to the use of resveratrol in the treatment of autoimmune diseases. On the other hand, it activates antitumor immunity. However, there are several problems that prevent the widespread use of resveratrol nowadays. In particular, its poor water solubility, bioavailability, and dosage. In order to place resveratrol as a cutting-edge molecule in medicine, additional multicenter and placebo-controlled trials have to be carried out.

THERAPEUTIC USE OF RESVERATROL IN THE TREATMENT OF NEUROLOGICAL AND ENDOCRINOLOGICAL PATIENTS.

The article represents the data characterizing the use of resveratrol in the treatment of various diseases, including endocrinological and neurological. It was shown that resveratrol is widely used in the treatment of various diseases due to its ability to actively suppress the inflammatory process. At the same time, in autoimmune diseases resveratrol inhibits the function of the entire population of T-cells, but when it comes to the neoplastic process, it only inhibits the activity of a subpopulation of T-cells (Treg). Thus, resveratrol can be recommended in the treatment of any diseases associated with the activation of the T-cell immunity.

VITAMIN D INSUFFICIENCY AS A RECENT PROBLEM FOR THE RESIDENTS OF TYUMEN CITY AND TYUMEN REGION.

The present work is dedicated to the study of vitamin D content among residents of Tyumen city and Tyumen region. The study analyzed the correlation between the level of vitamin D in the blood and the gender, age, place of residence and season of seeking medical care. This study was carried out on the basis of multidisciplinary clinic of Tyumen State Medical University (MDC of Tyumen SMU). During the research, 231 medical records were analyzed. It was estimated that 51% of patients (118 people) had insufficient blood content of vitamin D. This condition requires early and adequate treatment, since otherwise the risk of clinical manifestations of hypovitaminosis D increases. Considering the important biochemical role of this vitamin in the body (it is proved that vitamin D is not only involved in the regulation of phosphorus-calcium metabolism; almost all cells have receptors for it) and the increased risk of the consequences in case of hypovitaminosis, the conducted study is a pressing issue of our time.

FEATURES OF MANAGEMENT OF AUTOIMMUNE THYROIDITIS IN CHILDREN: A CASE REPORT.

The article reflects the main links of pathogenesis and diagnostic criteria for autoimmune thyroiditis (AIT) and subclinical hypothyroidism as well as presents formulated features of signs and symptoms, diagnosis, and therapy of this disease in children. Here, we present a case report of an adolescent patient with AIT that was treated with L-thyroxine. The feature of this case was the development of laboratory-confirmed drug-induced hyperthyroidism against the background of hypersensitivity to the drug, what required correction of the therapy.