[Effects of ubinon-9, a synthetic antioxidant, on intensity of lipid peroxidation in blood platelets and plasma of patients with ischemic heart disease]. / Vliianie sinteticheskogo antioksidanta ubinona-9 na intensivenost' perekisnogo okisleniia lipidov v thrombotsitakh i plazme krovi bol'nykh ishemicheskoi bolezn'iu serdtsa.

The antioxidant ubinon-9 was tested for its effects on platelet and plasma lipid peroxidation parameters in patients with acute ischemic heart diseases. The use of ubinon-9 in the multimodality therapy of patients with ischemic heart disease was shown to result in a significant decrease in lipid peroxidation intensity by enhancing superoxide dismutase activity in the platelets and plasma from the patients. Ubinon-9 equally prevented lipid peroxidation activation during enzymatic and nonenzymatic induction in the platelets of patients with unstable angina or acute myocardial infarction. Unlike a daily dose of 30 mg, 90 mg a day is a more effective dose in reducing platelet and plasma lipid peroxidation parameters. One may suggest that addition of ubinon-9 into the routine treatment regimen allows the therapy for acute ischemic heart disease to be optimize.

[Status of thrombocyte membranes and lipid peroxidation in patients with unstable stenocardia]. / Sostoianie membran i osobennosti perekisnogo okisleniia lipidov trombotsitov u bol'nykh s nestabil'noi stenokardiei.

Platelet and plasma lipid peroxidation (LPO) activity, and possible effect of LPO products on platelet membrane structure were examined in patients with unstable angina, an acute form of coronary disease. All parameters of LPO were increased both in the platelets and the plasma. It was demonstrated by spinning probes that platelet membrane S degree of order was increased significantly, an evidence of increased microviscosity, in patients with unstable angina. There also was a positive correlation between the S value and the level of LPO products. It is suggested that membrane disorders, in which CHD-related platelet hyperreactivity is rooted, may in part be due to PLO activation in the platelets.

[The possibility for the presumed detection of the obstructive lesion of the coronary arteries in stenocardia patients by the data from circadian ECG monitoring and stress tests]. / Vozmozhnost' predpolozhitel'nogo vyiavleniia obstruktivnogo porazheniia koronarnykh arterii u bol'nykh stenokardiei po dannym sutochnogo monitorirovaniia EKG i nagruzochnykh prob.

Whether 24-h ECG monitoring (ECGM) may be used in detection of multiple arterial obstructions in anginal patients and to compare diagnostic efficacy of ECGM and bicycle exercise (BE) in prediction of 2 or 3 lesions was investigated in 137 patients subjected to ECGM and selective coronarography. 117 of them did bicycle exercise. The number of episodes of painful and painless myocardial ischemia in ECGM was related with the extension and depth of the coronary flow obstruction. The overall index of myocardial ischemia has been estimated warranting higher probability of detection of subjects with obstruction in 1 or more coronary arteries. Sensitivity and prediction value of ECGM was similar to those of BE, but the latter was more specific.

[Kallikrein-kinin indices and biological composition of exhaled condensate in acute bronchitis patients with varying disease course]. / Pokazateli kallikrein-kininovoi sistemy krovi i biokhimicheskii sostav kondensata vlagi vydykhaemogo vozdukha u bol'nykh ostrym bronkhitom s razlichnymi variantami techeniia.

Parameters of blood kallikrein-kinin system (KKS) and biochemical composition of humor condensated from the exhaled air have been evaluated in 87 patients with acute bronchitis (36 cases with lingering course and 31 with recurrent). The progression of acute bronchitis is associated with elevated blood concentrations of acute-phase proteins, KKS activation in the blood and high serotonin and lactic acid content in the humor condensated from the exhaled air. Lingering and recurrent course of the disease are characterized by more pronounced reduction in inhibitory activity of kallikrein, in activity of angiotensin-converting enzyme and emergence of noradrenalin in high concentration.

[The use of halotherapy for the rehabilitation of patients with acute bronchitis and a protracted and recurrent course]. / Primenenie galoterapii dlia reabilitatsii bol'nykh ostrym bronkhitom s zatiazhnym i retsidiviruiushchim techeniem.

Halotherapy was used for rehabilitation in 25 patients with acute bronchitis of long-standing and recurrent types. The main therapeutic action was ensured by aerodispersed medium saturated with dry highly dispersed sodium chloride aerosol, the required mass concentration being maintained in the range of 1 to 5 mg/m3. Therapy efficacy was controlled through assessment of clinical, functional, immunological and microbiological findings. Metabolic activity values were taken into consideration as well. Positive dynamics of the function indices in the clinical picture resulted from elimination of pathogenic agents, control of slowly running inflammatory lesions and stimulation of some immune system factors. Favourable changes in metabolic activity were present: normalization of serotonin excretion, marked decrease of unbalance in lipid peroxidation-antioxidant system.