Gross and histopathologic diagnoses from North Atlantic right whale Eubalaena glacialis mortalities between 2003 and 2018.

Seventy mortalities of North Atlantic right whales Eubalaena glacialis (NARW) were documented between 2003 and 2018 from Florida, USA, to the Gulf of St. Lawrence, Canada. These included 29 adults, 14 juveniles, 10 calves, and 17 of unknown age class. Females represented 65.5% (19/29) of known-sex adults. Fourteen cases had photos only; 56 carcasses received external examinations, 44 of which were also necropsied. Cause of death was determined in 43 cases, of which 38 (88.4%) were due to anthropogenic trauma: 22 (57.9%) from entanglement, and 16 (42.1%) from vessel strike. Gross and histopathologic lesions associated with entanglement were often severe and included deep lacerations caused by constricting line wraps around the flippers, flukes, and head/mouth; baleen plate mutilation; chronic extensive bone lesions from impinging line, and traumatic scoliosis resulting in compromised mobility in a calf. Chronically entangled whales were often in poor body condition and had increased cyamid burden, reflecting compromised health. Vessel strike blunt force injuries included skull and vertebral fractures, blubber and muscle contusions, and large blood clots. Propeller-induced wounds often caused extensive damage to blubber, muscle, viscera, and bone. Overall prevalence of NARW entanglement mortalities increased from 21% (1970-2002) to 51% during this study period. This demonstrates that despite mitigation efforts, entanglements and vessel strikes continue to inflict profound physical trauma and suffering on individual NARWs. These cumulative mortalities are also unsustainable at the population level, so urgent and aggressive intervention is needed to end anthropogenic mortality in this critically endangered species.

Increased immunohistochemical expression of neutral metalloendopeptidase (enkephalinase; EC 3.4.24.11) in villi of the human placenta with pre-eclampsia.

The purpose of this study was to identify the presence of placental neutral metalloendopeptidase (NEP; enkephalinase; EC 3.4.24.11) in human normotensive and pre-eclamptic pregnancy. The localization of NEP in placentae from normotensive, chronic hypertensive and pre-eclamptic pregnancies was carried out on fresh frozen tissues by using a monoclonal primary antibody developed against human common acute lymphoblastic leukaemia antigen (CD10) together with the avidin-biotin-peroxidase method. In placentae from normotensive, chronic hypertensive and superimposed pre-eclamptic pregnancies, intense staining was found in the extravillous trophoblast, and also in fibroblasts of the chorionic plate and stem villi. Light to moderate staining was noted in the villous-associated trophoblast and in some cells from the villous core. In cases of pre-eclampsia, very intense staining was detected not only on the surface, but also in the cytoplasm of the villous-associated trophoblast. The increased expression of placental NEP in pre-eclampsia suggests that this enzyme may be involved in the regulation of the local concentration of circulating biologically active peptides at the fetomaternal interface, and thus could be implicated in the pathophysiological changes of this syndrome.

Risk factors associated with moderate and serious injuries attributable to the 1994 Northridge Earthquake, Los Angeles, California.

PURPOSE: The purpose of this study was to use emergency department data to estimate levels of morbidity and risk factors due to earthquake-related mechanisms of injury subsequent to an urban night-time earthquake. METHODS: Data were abstracted from 4190 medical records for the month of January, 1994. Injuries attributable to the earthquake were identified through emergency department and medical records. These injuries were: (a) categorized by mechanism of injury; (b) assigned an injury severity score; and (c) linked to structural and geologic data. Proportional polytomous and dichotomous logistic regression were used to estimate risk of more severe injury associated with demographic characteristics, injury characteristics, structural characteristics, and geologic factors. RESULTS: More severe earthquake-related injuries (serious versus moderate and moderate versus minor) were statistically significantly associated with patient age (> or = 60 years old), upper extremities, falling, multi-family structures, pre-1960 housing, and the 50th percentile of Peak Ground Acceleration, after adjusting for all other available demographic, injury, structural, and geologic characteristics. CONCLUSIONS: The current recommendation of 'duck, cover, and hold' might not be optimal during a nighttime earthquake, particularly if individuals are in the padded environment of the bed. Actions such as reaching for or catching objects, bracing, or holding onto perceived stable objects may increase risk for more serious injury. Alternate responses include assuming a tucked position (as in airline crashes) or staying in bed for non-ambulating people. Structural damage and structure size were not associated with more serious injuries, but structure use and age were, leading the authors to suspect that unmeasured socioeconomic factors might impact risk factors. The importance of including population demographic characteristics in hazard modeling is emphasized.

Fatal and hospitalized injuries resulting from the 1994 Northridge earthquake.

BACKGROUND: The Northridge earthquake struck Los Angeles on 17 January 1994, originating from a previously unknown thrust fault. The earthquake measured 6.7 on the Richter scale and caused extensive damage to buildings, utilities and roadways. This report describes injuries occurring in the Northridge earthquake which resulted in death or hospital admission. METHODS: Earthquake-related deaths were identified by the Los Angeles Department of the Coroner. All 78 hospitals in Los Angeles County were screened for earthquake-related admissions and were found in 16 of them. Coroner's records and medical records from the 16 hospitals were individually reviewed to identify earthquake-related injuries and to obtain information about the injury. RESULTS: A total of 171 earthquake-related injuries was identified in Los Angeles County, 33 were fatal and 138 required hospital admission. Injury rates were approximately equal by gender and increased significantly with increasing age. Most of the fatalities were due to building collapse, and most of the hospital-admitted injuries were caused by falls or being hit by objects. Motor vehicle injuries and burns were also common causes of injury. Head and chest injuries were common among fatalities, and extremity injuries were the most common among those admitted to a hospital. CONCLUSION: Earthquakes cause injuries through many mechanisms, and a clearer understanding of these pathways can help focus prevention strategies. Research combining comprehensive surveillance with risk factor assessment can help identify behaviours and circumstances increasing the risk of injury in an earthquake.

Reported satisfaction, fluctuation of vision, and glare among patients one year after surgery in the Prospective Evaluation of Radial Keratotomy (PERK) Study.

We studied satisfaction with the results of radial keratotomy one year after surgery on one eye as reported by 354 patients in the Prospective Evaluation of Radial Keratotomy (PERK) Study. We measured satisfaction using an index based on ten questions that were part of a longer psychometric questionnaire. Patients were generally satisfied with the results of radial keratotomy-48% were very satisfied, 42% were moderately satisfied, and 10% were dissatisfied. A lot of trouble with fluctuating vision was reported by 12% of patients before surgery and by 34% one year after surgery; 17% reported a lot of trouble with glare both before surgery and one year after surgery. The three major factors that influenced satisfaction were uncorrected visual acuity, residual refractive error, and subjective daily fluctuation in vision. A multiple regression equation that incorporated these three variables, glare, and patient sex was able to predict only 46% of the variance in patient satisfaction.

Psychosocial characteristics of candidates for the prospective evaluation of radial keratotomy (PERK) study.

The National Eye Institute Prospective Evaluation of Radial Keratotomy (PERK) Study is a multicenter clinical trial for the evaluation of radial keratotomy. This article describes the questionnaire data collected on PERK patients and compares them with a similar group of myopic persons studied during the Rand Health Insurance Experiment (heretofore referred to as the Rand study). The PERK patients are young, white myopes who dislike being dependent on corrective lenses but perceive themselves to be more visually impaired than do comparable Rand study myopes. Most female subjects and a plurality of the male subjects have tried contact lenses and quit wearing them mainly because use of the lenses was inconvenient or bothersome. There is no evidence that patients are psychologically or socially deviant. Both male and female subjects expressed a fear of being without vision and cited impatience with the lenses as their major motivation for wanting surgery.

Comparison of ketorolac tromethamine, diclofenac sodium, and moist drops for ocular pain after radial keratotomy.

PURPOSE: To compare the 2 most popular commercially available topical nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of ocular pain following radial keratotomy (RK). SETTING: Multicenter clinical trial. METHODS: Ninety-seven RK patients were randomly assigned to 1 of 3 treatment groups: ketorolac tromethamine, diclofenac sodium, and moist drops as a control. The patients used 1 drop of the masked medication and 1 drop of ofloxacin 3 times a day for 3 days prior to surgery. They received 1 drop of the masked medication 1 hour before surgery, immediately after surgery, and 4 times a day thereafter. Patients were given a written questionnaire preoperatively and were also instructed to call a central computerized telephone system to answer prerecorded questions about ocular comfort. The calls were placed 30 minutes and 1, 2, 3, 4, 5, 6, 24, and 48 hours after surgery. RESULTS: Two hundred ten statistical values were calculated to compare symptoms in the unoperated eye at baseline with symptoms in the operated eyes at each of 9 postoperative time points. Only 7 of the 210 values (3.3%) were significantly different among patient groups (operated versus unoperated eyes) by psychometric testing. CONCLUSIONS: Both ketorolac tromethamine and diclofenac sodium were more effective in reducing post-RK discomfort than the control (moist artificial tears). Given the large number of tests and the small number that tested as significant, the significant differences (7 of 210 measurements) observed among the 3 treatment groups probably occurred by chance, although the improved foreign-body sensation, functionality, and compliance scores in the ketorolac group during the first 4 hours might be clinically important.

Does the public understand the differences between ophthalmologists and optometrists?

Telephone interviews utilizing random digit dialing were conducted in Los Angeles County to assess the public's knowledge of differences between ophthalmologists and optometrists and to determine factors predictive of knowledge status. Knowledge status was determined by performance on a questionnaire specifically designed for this study. Using multiple logistic regression analysis for simultaneous evaluation of potentially predictive factors, higher education, history of prior eye examination as an adult, and history of prior or present contact lens or spectacle wear were associated with scoring as knowledgeable. Predicted probabilities of being knowledgeable and not knowledgeable were presented for all combinations of these predictive variables. Such information may be helpful in guiding public education campaigns regarding eye care.

Associations of self-reported dental health and general health measures in the Rand Health Insurance Experiment.

Data from the Rand Health Insurance Experiment (HIE) are used in exploratory analyses to examine the associations of self-reported dental health with general health measures. Responses of 1658 dentulous participants 18-61 yr of age are examined. Patterns of association among and between items of the physical, mental, social, and general health indices and a three-item measure of self-reported dental health are tested using principal component analyses. Findings suggest that dental health represents a separate dimension of health that is not fully accounted for by other health measures. However, while dental health may be considered an independent health construct, the dental health index was weakly but statistically significantly associated with the general health perceptions index and, to a lesser extent, to the mental health index and the two physical health indices. Improved self-reported measures of dental health status, studied in association with other general health measures, will allow us to better define oral health, and patients' perceptions of oral health, particularly in relation to other general health perceptions. In addition, a valid and reliable multidimensional oral health measure would be valuable as a potential cost-effective method of epidemiologic data collection, as well as a tool for evaluating the effectiveness of oral health interventions, and for providing data for dental health policy making and planning.

Occupational status and suicide.

The relationship between occupational status and suicide was examined using data from Sacramento County, California. Data were obtained from coroner's records filed routinely on all cases of sudden, violent, or unexpected death since 1925. Occupation- and age-specific suicide rates were calculated for males and age-adjusted for overall comparison for the decades 1945-1954, 1955-1964, and 1965-1974. Findings show an inverse relationship between occupational status and suicide for all age groups over the past 30 years. Over time, male suicide rates have increased particularly for employed males over 65, employed males aged 14 to 24, and males in low-status occupations. General economic insecurity among workers of low socioeconomic status (SES), particularly the elderly, is suggested as a contributing factor to these trends.

Attributes of suicide in females.

Long-term trends in suicides among females were investigated using data from Sacramento County, California. Of the 3,741 cases, 3,398 were Caucasian and 952 (25.4 percent) were females. These analyses focus on 837 Caucasian and Hispanic females. Female suicide rates in Sacramento County have increased gradually since 1925 with a corresponding decline in the male/female sex ratio. The suicide data suggest that a minimum of three types of female suicides can be identified and that the incidence of each type varies with the age of the women. Indicators that help in identifying cases and in tentatively describing an etiology include marital status, employment status and occupation, physical ill health, familial loss or disruption, and psychiatric symptoms.

Prevalence of assault and perception of risk of assault in urban public service employment settings.

This study describes the prevalence and correlates of physical assaults, threats of assault, and workers' perceptions of safety in selected urban employment settings. Questionnaires were mailed to a random sample of 1,763 persons working at various jobs and sites throughout Los Angeles County. Workers were asked to describe their work environments, their perceptions of personal safety at work, and physical assaults and threats they had experienced. Three percent of the respondents reported being assaulted within the previous year and 14% reported being threatened within the previous 30 days. Younger workers, more educated workers, and those who worked with clients or patients were more likely to report assaults. Approximately one third of those who reported threats or assaults described the perpetrator(s) as clients, patients, or persons in legal custody, and one third described the perpetrator(s) as co-workers or supervisors. Fifty-two percent of the workers reported being concerned about their safety at work.

Examining self-perceived first-aid abilities after the Northridge earthquake.

INTRODUCTION: This study examines those factors predictive of self-perceived first-aid abilities among a community-based sample after the 1994 Northridge earthquake. METHODS: A probabilities-proportionate-to-size (pps) sample of residents of Los Angeles Country and 11 pre-selected zip codes from southeastern Ventura County was selected using computer-generated random digit-dialing (rdd) procedures 7-11 months after the earthquake. Data were collected from 506 individuals in 45 minute interviews. A unidimensional scale of self-perceived first-aid ability was created and represents the dependent variable in a causal path model. RESULTS: In a causal path model, standardized path coefficients suggested that while reports of taking first-aid courses were the most influential factors in predicting higher self-perceived first-aid abilities, other factors including being white, younger, speaking English in the home, and lower income also predicted higher self-perceived first-aid abilities that were independent from taking formal first-aid courses. CONCLUSIONS: First-aid training should be directed towards target segments of the population that are not likely to have had instruction in these basic skills. Those individuals who self-report high first-aid proficiency, independent of formal first-aid training, should be evaluated to assess their abilities to perform these skills.

Correlates of self-reported dental health status upon enrollment in the Rand Health Insurance Experiment.

This study explored the personal impact of dental problems in terms of pain, worry, and conversation avoidance, and factors associated with this impact. A self-reported dental health index, comprising three questions asked of participants in the Rand Health Insurance Experiment, was examined. Index reliability was 0.69. One-way analysis of variance and Pearson's product-moment correlations were used to explore the bivariate associations between the index and sociodemographic variables, provider-assessed clinical indicators, and the respondent's report of a toothache. Perceived dental health of the study sample (N = 1,658) was notably lower in the presence of a toothache, increasing numbers of decayed teeth, and worsening periodontal health. Weaker, but statistically significant, associations were observed for sociodemographic factors. Nonwhites and those persons with lower educational and income levels reported more impact. In regression analysis, standardized coefficients indicated that the respondent's report of a toothache and, secondarily, numbers of decayed teeth were the most important explanatory factors. These findings suggest that in the future improved self-reported measures, in addition to clinical indicators, may be an acceptable and cost-effective method of epidemiological data collection and dental health outcome assessment.

Suicide among adolescents in Sacramento County, California 1950-1979.

Suicide is one of the three leading causes of death among adolescents. More importantly, the rate of suicide is on the increase among both male and female adolescents (Tischler, McKenry, & Morgan, 1981). Data from the United States show that approximately 25,000 persons commit suicide each year (Coleman, 1976), and almost one-fifth of these are in the 15 to 24 year age group (Hendin, 1975). More disturbing is that a large number of adolescent suicides go unreported and that up to 50% of all these unreported suicides are categorized as "accidents" (Toolan, 1964). Utilizing suicide data collected in Sacramento County, California between 1925 and 1979, we analyzed suicides among persons aged 10 to 24 to determine if there are sociodemographic factors or presuicide behaviors which discriminate between male and female suicides, suicides of different ages, or explain the increase in suicide rates, and to compare adolescent suicide rates in Sacramento County with national findings.

A randomized controlled trial of facilitating information giving to patients with chronic medical conditions: effects on outcomes of care.

BACKGROUND: The purpose of this study was to assess the impact of an intervention to facilitate information giving to patients with chronic medical conditions on outcomes of care. METHODS: A consecutive sample of 276 eligible patients with chronic medical conditions at a family medicine clinic was randomized to control and experimental interventions. A total of 205 completed the study. Experimental group patients received copies of their medical record progress notes, and they completed question lists for physician review, while control group patients received health education sheets and completed suggestion lists for improving clinic care. Self-reported physical functioning, global health, and patient satisfaction and adherence were measured at enrollment and after the interventions. Visit lengths and patient response to medical record sharing after the interventions were also measured. RESULTS: After the intervention, experimental group patients reported 3.7% better overall physical functioning than did control patients (mean = 83.6, standard deviation [SD] = 17.6 vs mean = 79.9, SD = 25.3; P = .005 after adjusting for covariates). The experimental group was more satisfied with their physician's care (mean = 31.4, SD = 4.6 vs mean = 31.3, SD = 5.2; P = .045 after adjusting for covariates). They were also more interested in seeing their medical records than were control patients (mean = 12.0, SD = 2.8 vs mean = 11.2, SD = 2.8; P = .002 after adjusting for covariates). Experimental group patients also reported an 8.3% improvement in overall health status (postintervention mean = 3.0, SD = 1.1) compared with their pre-intervention health status (mean = 2.8, SD = 1.0; P =.001). Visit lengths for patients in the experimental group did not differ from those of the control group. CONCLUSIONS: A simple patient-centered intervention to facilitate information giving in the primary health care of patients with chronic medical conditions can improve self-reported health, physical functioning, and satisfaction with care.

Risk perceptions and behavioral intentions for Hepatitis B: how do young adults fare?

Young adults are at risk for Hepatitis B infection. Little is known about their attitudes and beliefs concerning Hepatitis B, which are determinants of getting immunized. This investigation examined risk perceptions and behavioral intentions concerning Hepatitis B among a convenience sample of 1070 young adults, 18-24 years old who participated in a Hepatitis B campaign that aired a prevention-based advertisement in movies. The campaign did not produce any significant effects. Therefore, analyses presented in this paper explored whether risk perceptions and intentions vary by sociodemographic characteristics. Most young adults do not perceive themselves to be at risk for Hepatitis B, but perceive other people to be at risk. Gender and ethnic differences in behavioral intentions to seek out Hepatitis B information were also observed. This study offers insight about important factors to consider when designing Hepatitis B prevention interventions for young adults and suggests that increasing health-promotion efforts for this group, while accounting for differences in age, culture and gender, are warranted.

Life graphs and life events.

The present study investigates changes in personal satisfaction over the whole life course by means of life graphs and their determinants. The life graphs were administered within a 4-year interval to 371 individuals (age 45-70). A modified version of the Holmes and Rahe life events scale, administered in the second interview, was used to ascertain the occurrence of four kinds of events: (1) children leaving home, (2) ill health, (3) death of family or friends, and (4) changes in work. Differences in height between the peak of the graph and the height at the current age is the measurement technique used with the life graphs. Events are found to play a different role at different stages of life and seem to be measured against an implicit schedule according to which the events are seen as traumatic or acceptable. Thus, the same event has different effects on perception of emotional state according to age.