[Regional differences in compulsory treatment in mental health care in the Netherlands during 2013-2017]. / Gedwongen opnames en ambulante dwang in de ggz: onderzoek naar regionale verschillen tussen arrondissementen, leeftijdsgroepen en unieke personen, 2013-2017.

BACKGROUND: Compulsory treatment in mental health care has continuously increased for years. Registration of court ordered compulsory psychiatric care is based upon counts of legal authorisations. These counts do not refer to number of individual persons involved.
AIM: To report the number age-specific prevalence of coercion in psychiatric care, number of persons involved, age distribution and regional differences.
METHOD: Analysis of the number of requests for compulsory care and population size according to the age groups for the years 2013-2017. We used direct age standardisation at the level of jurisdiction regions.
RESULTS: The annual number of unique persons for whom compulsory care was requested was 28% less than the number of requested court orders. The annual increase in compulsory care was 3%. Per specific treatment order the increase during 2013-2017 was 12% for emergency compulsory admissions, 8% for hospital admissions, 10% for extended hospital admissions and 43% for community treatment order.
CONCLUSION: The number of persons for whom compulsory mental care is requested increased on average by 3% each year. Greatest increase was observed for age groups 25-44 years and 80 years and older. After age-standardisation substantial differences remain between jurisdiction regions.

Association between physical exercise and psychosocial problems in 96 617 Dutch adolescents in secondary education: a cross-sectional study.

Background: Psychosocial problems negatively affect school performance, social skills and mental development. In recent years, researchers have investigated the relationship between physical activity and psychological health. With this large school-based study, we examined whether physically inactive adolescents and slightly active adolescents experience more psychosocial problems compared with active adolescents. Methods: This study is based on the Dutch National Youth Health Monitor. This monitor uses a, school-based, cross-sectional questionnaire conducted among 96 617 adolescents in 2015. To examine the association between physical exercise and psychosocial problems, multi-level linear regression was carried out. Results: The weighted average Strengths and Difficulties Questionnaire score of active adolescents was lower than that of inactive adolescents. Adolescents who are inactive had 12% (ß = 1.12; 95% CI: 1.10-1.14; P <0 .001) more psychosocial problems compared with active adolescents. Further, inactive adolescents had a higher score on the subscales emotional problems (ß = 1.19; 95% CI: 1.17-1.22; P < 0.001) and problems with peers (ß = 1.16; 95% CI: 1.14-1.19; P < 0.001). There was no statistical significant difference in total score of the Strengths and Difficulties Questionnaire between active and slightly active adolescents. Conclusion: Physically active adolescents have fewer psychosocial problems compared with physically inactive adolescents. Not only is this association significant, but there is an indication that it is also of clinical relevance.

[The number of compulsory admissions continues to rise: implications for the new Dutch law on obligatory mental health care]. / Stijgende trend in dwangtoepassing onder de Wet Bopz zet door; implicaties voor de nieuwe Wet verplichte geestelijke gezondheidszorg.

BACKGROUND: Since the introduction of the new Dutch law on compulsory mental health care, the Bopz, there has been a marked increase in the number of compulsory admissions in mental health care in the Netherlands. When the new law underwent its third evaluation in 2002, it was decided that the law no longer reflected current views on the admission policy in mental health care. The draft on a new law on compulsory admissions to mental health care has already been published. One of the goals of the new law is to reduce the number of compulsory hospital admissions and to ensure that patients with mental health problems receive compulsory community care and outpatient care. AIM: To describe and analyse the use of compulsory admissions and community treatment orders (CTOs), and to make recommendations. METHOD: We analyse the number of CTOs and court-ordered admissions in the Netherlands between 2003 and 2013 on the basis of figures supplied by the Council for the Judiciary. RESULTS: In the period 2003-2013 the number of compulsory emergency admissions increased from 43 to 47 per 100,000 inhabitants. During the same period the number of court-ordered admissions rose from 44 per 100,000 inhabitants in 2003 to 89 per 100,000 in 2013. (These figures include CTOs.) We were unable to perform more detailed studies because of the lack of records giving, for instance, the characteristics of patients who have undergone compulsory admission. CONCLUSION: Emergency compulsory admissions, CTOs and court-ordered admissions to mental health care continued to rise in the period 2003-2013. There is an urgent need for more detailed registration of the type an duration of compulsory admissions to psychiatric care and for more research into the type of treatment that can prevent the use of coercion to mental health care.

[The obligatory notification of pertussis is not effective for the protection of unvaccinated children]. / Meldingsplicht voor kinkhoest niet effectief om ongevaccineerde kinderen te beschermen.

OBJECTIVE: To determine the effectiveness of the obligatory notification of pertussis in the Netherlands and the measures based on this notification in the prevention of infection in unvaccinated or insufficiently vaccinated children. DESIGN: Descriptive, retrospective. METHOD: The period between the first day of the illness and the date of notification was calculated for all 9310 cases of pertussis that were notified in the Netherlands in 2004. A period of 21 days is the maximum during which appropriate measures can be taken in the family of the index patient to protect unprotected siblings at risk from infection. For the province of Groningen (n = 411 notified cases), it was also determined whether there were actually children that were not or insufficiently vaccinated in the immediate environment and whether preventive measures were necessary. RESULTS: In the Netherlands in 2004, 890 (10.7%) of all notified pertussis cases were notified within a three-week period after the first day of illness. In Groningen, this number was 30 (9.1%) and in none of these cases was there an insufficiently vaccinated child in the family. CONCLUSION: In an endemic situation with severe under-reporting, the obligatory notification of pertussis is not effective to prevent infection of insufficiently vaccinated children. Alternative vaccination strategies directed at the prevention of the spread of pertussis among insufficiently vaccinated children would probably be more effective and merit further investigation.

Changing patterns in emergency involuntary admissions in the Netherlands in the period 2000-2004.

BACKGROUND: In England, rates of involuntary admissions increased in subgroups of patients. It is unknown whether this is true in other European countries. AIMS: To establish whether the increase in emergency commitments was uniform across subgroups of patients and dangerousness criteria used to justify commitment in The Netherlands. METHOD: National data on all commitments in the period 2000-2004. RESULTS: Commitments increased from 40.2 to 46.5 (16%) per 100,000 inhabitants. Controlling for population changes in age and sex, relatively large increases were found in patients over 50 years (25-40% increase), in patients with dementia (59%), 'other organic mental disorders' (40%) and substance abuse (36%). 'Arousing aggression', increased most strongly as a dangerousness criterion for commitment (30%). CONCLUSION: Changing patterns of commitments in The Netherlands and England might indicate a wider European shift in diagnoses and reasons for admission of committed patients.

[Accelerated increase in the number of involuntary admissions following the implementation of the Dutch Act on Compulsory Admission to Psychiatric Hospitals (BOPZ)]. / Versnelde stijging van het aantal inbewaringstellingen na de invoering van de Wet Bijzondere Opnemingen in Psychiatrische Ziekenhuizen (BOPZ).

OBJECTIVE: To determine whether the observed accelerated increase in the number of involuntary admissions in The Netherlands coincides with the implementation of the Dutch Act on Compulsory Admission to Psychiatric Hospitals (BOPZ) in 1994. DESIGN: Retrospective. METHOD: The extent to which the number of involuntary admissions changed after implementation of the BOPZ was examined by means of Poisson regression on the basis of national data from the Patient Registration of Intramural Mental Healthcare for the period 1979-1995 and data from the Healthcare Inspectorate for the period 1992-2004. For this purpose, the curve prior to implementation of the BOPZ was compared with that following its implementation. RESULTS: The number of involuntary admissions of psychiatric patients had more than doubled in 25 years, from 3101 in 1979 to 7450 in 2004. The increase in annual numbers accelerated significantly after implementation of the BOPZ in 1994. CONCLUSION: There was an accelerated increase in the number of involuntary admissions after the implementation of the BOPZ. Other possible contributing factors include an increased number of admissions, shorter hospital stays, and changes in social concepts.

[Reduction in the consumption of benzodiazepines due to a letter to chronic users from their own general practitioner]. / Vermindering van gebruik van benzodiazepinen door een brief van de eigen huisarts aan chronische gebruikers.

OBJECTIVE: To investigate the effectiveness of a minimal intervention in reducing the volume of prescription of benzodiazepines at the regional level. DESIGN: Prospective. METHOD: Patients on compulsory health insurance who had received 180 or more daily doses of benzodiazepines in the course of one year received a letter from their general practitioner (GP) with information about the risks of chronic use, the advice to reduce or stop use, and an invitation to make an appointment to discuss the problem. This intervention took place in 19 GP practices in East Groningen. A reminder was sent six months later to the patients who had not responded in 9 randomly selected GP-practices. Thirty-seven practices in East Groningen and 91 practices in Northwest Groningen served as controls. Outcome measures were: (a) the percentage of patients who stopped, and (b) the change in average benzodiazepine consumption. RESULTS: During the period 6-12 months after the first letter in the intervention group (n = 1343), 11.3% of the patients (95% CI: 9.6-13.1) received no prescription whatsoever for benzodiazepines compared to 5.4% (4.6-6.3) and 4.9% (4.2-5.5) in East Groningen (n = 2932) and in Northwest Groningen (n = 4562), respectively. The average decrease in prescription volume was 13% (-9.9 to -15.1) in the intervention group compared to 3% (-0.1 to -4.1) and 3% (-1.5 to -4) in the control groups. The reminder sent half a year later had no additional effect. CONCLUSION: The informative letter from the GP to chronic users of benzodiazepines with the advice to stop or reduce this use was effective.

Longer pre-hospital delay in acute myocardial infarction in women because of longer doctor decision time.

STUDY OBJECTIVE: To measure the pre-hospital delay times in patients with proven acute myocardial infarction (AMI) and to identify possibilities for reduction of treatment delay. DESIGN: Descriptive three centre study. SETTING: One university teaching hospital and two regional hospitals in Groningen, the Netherlands. PATIENTS: 400 consecutive confirmed AMI patients, age below 75 years, admitted to coronary care departments. MAIN RESULTS: Mean age was 59 years and 78% of patients were men. Within two hours after onset of symptoms half of the patients with AMI arrived at the hospital. Patient, doctor, and ambulance delay times (median values) were 30, 38, and 35 minutes respectively. Calling the personal general practitioner (GP) or the locum tenens and whether or not the AMI occurred during a weekend or on a working day had no consequences for pre-hospital delay times. At night patients waited longer before calling a GP than in the daytime. There was a positive correlation between patient and doctor delay. Twenty two per cent of AMI patients waited two hours or more before calling a GP. Total pre-hospital delay times differed between men and women. Longer doctor delay in women (36 minutes for men and 52 minutes for women) was caused by displacement of specific symptoms, in particular in women. AMI patients who were alone during onset of symptoms showed higher patients delay (72 compared with 23 minutes). CONCLUSION: In hospital admitted patients younger than 75 years pre-hospital delay times are within acceptable limits. In some subgroups further reduction is attainable, for example in patient delay outside office hours and when patients are alone during onset of symptoms, in doctor delay in cases where women present with symptoms suggestive for AMI. Improvement of facilities for pre-hospital electrocardiographic diagnosis may facilitate decision making by GPs. Good opportunities for further reduction of treatment delay exist in shortening of hospital delay.

The recombinant human histones H1 zero and H1.2 cause different toxicity profiles on the human leukemia cell line K562.

The human histones H1 zero and H1.2 were expressed in E. coli and purified to homogenity. Their cytotoxicity on the human leukemia cell line K562 and on PBMC from healthy volunteers was compared with the cytotoxic effect of a bovine histone H1 preparation. In this preparation, histone H1.2 was identified as the main compound. All three histone preparations induced a significant dose-dependent toxicity on the leukemia cell line. Compared with the recombinant histone H1 zero, the bovine preparation and recombinant H1.2 showed stronger cytotoxicities. Cytotoxic effects on K562 cells were observed immediately after addition of the histones, whereas the histone preparations failed to induce significant cytotoxicity on PBMC during the first hour of incubation. However, after 24 hours all three histone preparations induced toxic effects on PBMC which were comparable to those observed on the leukemia cell line.

Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease.

BACKGROUND: Prevention of coronary heart disease (CHD) in high-risk subjects. OBJECTIVE: To investigate the associations of dietary intake of alpha-linolenic acid (ALA) and linoleic acid (LA) as assessed by food frequency questionnaire and in the plasma cholesteryl ester (CE), with CHD risk factors. DESIGN: Baseline data of a double-blind, randomized placebo-controlled trial. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two other CHD risk factors (n=266). RESULTS: The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r=0.37, r=0.21, and r=0.42, respectively; P<0.01). In multivariate analysis, CE ALA was inversely associated with diastolic blood pressure (r=-0.13; P<0.05) and positively with serum triacylglycerol (r=0.13; P<0.05), and CE LA was inversely associated with serum triacylglycerol (r=-0.32; P<0.01). The CE LA/ALA ratio was strongly inversely associated with CE ALA (r=-0.95; P<0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energy % ALA (1.2 g/day), 8.4 energy % LA and an LA/ALA ratio of 21, and in the highest quintile 0.6 energy % ALA (1.7 g/day), 6.8 energy % LA and 12 (ratio). In the lowest quintile of CE ALA the diastolic blood pressure was 4 mm Hg lower (P trend<0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile. CONCLUSIONS: In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration.

Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis.

OBJECTIVE: To investigate the effects of increased alpha-linolenic acid (ALA)-intake on intima-media thickness (IMT), oxidized low-density lipoprotein (LDL) antibodies, soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP), and interleukins 6 and 10. DESIGN: Randomized double-blind placebo-controlled trial. SUBJECTS: Moderately hypercholesterolaemic men and women (55 +/- 10 y) with two other cardiovascular risk factors (n = 103). INTERVENTION: Participants were assigned to a margarine enriched with ALA (fatty acid composition 46% LA, 15% ALA) or linoleic acid (LA) (58% LA, 0.3% ALA) for 2 y. RESULTS: Dietary ALA intake was 2.3 en% among ALA users, and 0.4 en% among LA users. The 2-y progression rate of the mean carotid IMT (ALA and LA: +0.05 mm) and femoral IMT (ALA:+0.05 mm; LA:+0.04 mm) was similar, when adjusted for confounding variables. After 1 and 2 y, ALA users had a lower CRP level than LA users (net differences -0.53 and -0.56 mg/l, respectively, P < 0.05). No significant effects were observed in oxidized LDL antibodies, and levels of sICAM-1, interleukins 6 and 10. CONCLUSIONS: A six-fold increased ALA intake lowers CRP, when compared to a control diet high in LA. The present study found no effects on markers for atherosclerosis. SPONSORSHIP: The Dutch 'Praeventiefonds'.

[High mortality due to infectious diseases and unnatural causes of death among asylum seekers in the Netherlands, 1998-1999]. / Hoge sterfte door infectieziekten en niet-natuurlijke doodsoorzaak onder asielzoekers in 1998-1999.

OBJECTIVE: Description of causes of death among asylum seekers in the Netherlands compared to the Dutch standard population and identification of preventive measures to avoid preventable death. METHODS: An analysis of the causes of death of asylum seekers accommodated in housing facilities of the Central Organ Asylum seekers (COA) for the period 1998-1999 was performed. The primary cause of death was attributed using the International Classification of Diseases (ICD-10) and grouped according to the most important causes of death list issued by Statistics Netherlands. After stratification for gender and age standardised mortality ratios (SMR) were computed. RESULTS: In 82% of the observed deaths amongst asylum seekers a description of the cause and circumstances of death could be obtained. During the 2-year study period 156 asylum seekers died (of which 49 due to an unnatural cause of death and 15 due to infectious diseases). Fourteen stillbirths were registered in an index population of 37,688 in 1998 and 54,110 in 1999. The crude mortality rate was 1.95 per 1000 for male asylum seekers and 1.25 per 1000 for female asylum seekers. Compared to the Dutch standard population, the SMR was 1.23 (95%-CI: 1.01-1.42) for male asylum seekers and 0.85 (0.59-1.11) for female asylum seekers. The elevated mortality in male asylum seekers was due to the high mortality for infectious diseases with an SMR of 4.1 (1.3-6.9) and unnatural death with an SMR of 2.5 (1.7-3.2). More specifically, drowning had an SMR of 11.1 (2.3-20.7), murder and manslaughter 7.3 (2.5-12.0) and suicide 2.8 (1.5-4.1). AIDS accounted for half of the mortality due to infectious diseases. CONCLUSION: In 1998-1999, drowning, murder, manslaughter and suicide contributed significantly to an elevated mortality rate amongst male asylum seekers in the Netherlands. Some of these unnatural deaths could be avoided by implementing preventive measures.

[The organization and implementation of influenza vaccination in Groningen, 1993-1996]. / Organisatie en uitvoering van de influenzavaccinatie in Groningen, 1993-1996.

OBJECTIVE: To find out to what extent the recommendations from the standard 'Influenza and influenza vaccination' of the Dutch association of general practitioners (NHG) were implemented by the GPs in the period 1993-1996. DESIGN: Descriptive questionnaire study. SETTING: Municipal Health Services Groningen, the Netherlands. METHOD: All GPs active in the province of Groningen were sent a questionnaire in the period 1993-1996. Practical support of GPs in organizing influenza vaccination was offered as a part of the project 'Preventie: maatwerk' (Prevention made to measure). RESULT: Automated selection of risk patients showed a distinct increase over the years. This increase was greatest in 1996, especially in rural practices. Inviting by personal letter, as recommended in the NHG standard increased to 48% in 1996. Not all GPs organized special vaccination office hours. An increasing number offered vaccination at other times as well. In urban municipalities, vaccine was available in the practice less often. Half the GPs reminded risk patients of the vaccination if they failed to appear. The recorded number of vaccinated patients in Groningen was 9.5% of the population in 1994 (nation-wide: 10.8%), 10.8% in 1995 (nation-wide: 11.5%) and 15.4% in 1996 (nation-wide: 15.2%). CONCLUSION: The attention for programmed prevention in general practice went together with an increase of activities regarding influenza vaccination. Regional monitoring of the influenza vaccination provides data with which the prevention programme can be improved.

[Psychosocial consequences of screening for microalbuminuria and for some other risk factors]. / Psychosociale gevolgen van een screening op microalbuminurie en op enkele andere risicofactoren.

OBJECTIVE: Obtaining insight into the psychosocial consequences of a screening programme for the progression of heart, vessel and kidney damage. DESIGN: Questionnaire investigation. METHOD: This study addressed participants in the 'Prevention of renal and vascular end-stage disease' (PREVEND) study, which included about 40,000 inhabitants of Groningen, the Netherlands, aged 28-75 years, who were asked to send in a vial with morning urine in order to detect microalbuminuria. People with microalbuminuria were invited to a general practitioners' laboratory to determine the risk factors: urinary protein concentration, blood pressure and blood cholesterol level. A questionnaire was sent to 335 participants of the screening who had received the screening results two weeks before. RESULTS: The response rate was 75%. A minority of the respondents diagnosed with risk factors, expressed some concern. No influence on the wellbeing of this group of participants was established. Almost one-third of the respondents stated that they now 'lived according to healthier principles' because of the screening. On the other hand, there was a certain 'certificate of health effect': about half the smokers and the physically inactive saw the favourable screening result as a legitimation for their life style. An unfavourable screening result had led to additional medical consumption in almost half the respondents. The respondents appreciated the screening and especially the lower-educated had a very positive attitude towards early diagnosis in general. CONCLUSION: The screening positives showed no diminished wellbeing; their health behaviour improved due to the screening and they had a higher medical consumption. About half the screening negatives regarded the results as a legitimation of their unhealthy life style.

[Regional differences in prehospital time delay for patients with acute myocardial infarction; Rotterdam and Groningen, 1990-1995]. / Regionale verschillen in de tijd tot ziekenhuisopname bij patiënten met een acuut myocardinfarct; Rotterdam en Groningen, 1990-1995.

OBJECTIVE: To describe pre-hospital delay times in patients with acute myocardial infarction (AMI) in two regions in the Netherlands: Groningen (a region with high mortality for coronary heart disease (CHD)) and Rotterdam (a region with low CHD mortality). DESIGN: Descriptive. METHOD: The pre-hospital treatment delay of AMI patients in Rotterdam in 1990-1991 versus 1993-1995 was compared and also compared between Groningen en Rotterdam (1993-1995). In each region 3 hospitals participated (1 academic, 2 regional). The data were collected with a structured interview within 7 days after onset of symptoms in hospitalized AMI patients (n = 924) or by interviewing relatives of deceased patients (n = 40). The median patient, general practitioner (GP) and ambulance delays were calculated. RESULTS: Total median pre-hospital delay was 2.5 hours (5-95-percentile: 50 min-36 hours). Median patient delay time was shorter in Groningen than in Rotterdam (respectively 30 and 45 min) and the same applied to doctor delay times (respectively 38 and 72 min). In Rotterdam doctor delay time decreased by 23 min between 1990-1991 and 1993-1995. Median ambulance delay was 30 min in Rotterdam and 35 min in Groningen. Total pre-hospital delay times of self referred patients were 32-78 min shorter than those of patients who consulted a GP before admission. CONCLUSION: Reduction of pre-hospital delay in Rotterdam between 1990-1991 and 1993-1995 was due to faster decision time by the GP. The short pre-hospital treatment delay in Groningen in hospitalized patients suggests that relatively more AMI patients die outside hospital which may contribute to the high CHD mortality in this region.

Simultaneous strategies to reduce demand for and problematic use of hard drugs.

The primary responsibility of (local) governments is to enable people to make healthy choices in order to promote public health. Social circumstances are important determinants of choices that people make. Social risk factors for problematic use of drugs should be reduced to a minimum. Health education goals need to be matched to the different developmental stages of drug use behaviours of subgroups in the population. Employment perspectives for school leavers form an essential ingredient of policies which aim to reduce the demand for 'hard' drugs in order to divert (young) people from drug careers. Primary preventive strategies form the backbone of public policies focused on reduction of demand for hard drugs. Primary preventive strategies are population based and implemented by the public and private sector. Secondary preventive strategies are focused on specific high-risk groups and aim to prevent the development of drug dependence and/or to reduce harm for drug users. Tertiary preventive strategies are directed at individual hard drug users and emphasize harm reduction and rehabilitation of drug users and seek to reduce the side-effects of problematic hard drugs use for the general population. Innovative applied research is needed to improve field methods for timely detection of problematic hard drug use. More information about 'invisible' (hidden) populations of integrated drug users may offer new insights and ingredients for preventive policies on hard drugs.

Psychosocial consequences of screening for albuminuria and certain other risk factors.

OBJECTIVE: To gain insight into the psychosocial consequences of a screening programme on the progression of heart, vascular and kidney damage. DESIGN: Over 85,000 people aged 28-75 were invited to participate in a screening for albuminuria. Nearly half of them sent in their morning urine of which almost 10,000 had a (slightly) elevated urinary albumin level. This latter group was invited to participate in a follow-up screening (24-hour urine samples, blood pressure, glucose, cholesterol) together with ±3,000 randomly selected subjects with a normal urinary albumin concentration. A questionnaire on the psychosocial consequences of the screening was sent to 335 participants of the screening programme each of whom had received their (positive or negative) screening results two weeks previously. RESULTS: The response rate was 75%. A minority of the respondents, diagnosed for risk factors, expressed some concern. No influence on the well-being of this group of participants could be established. Almost one third of the respondents claimed to follow a healthier lifestyle as a result of the screening. There are, however, also indications for a certain 'certificate of health effect': about half of the smokers and the physically inactive considered that the favourable screening results legitimated their unhealthy lifestyle. An unfavourable screening result led to additional medical consumption in almost half of the respondents. The respondents appreciated the screening and especially the less educated had a very positive attitude towards early diagnosis in general. CONCLUSIONS: Those screened positive showed no diminished well-being; their health behaviour improved because of the screening and their medical consumption increased. Many of those screened negative considered the test result a reason to continue their unhealthy lifestyle.

Molecular radiotherapy: the NUKFIT software for calculating the time-integrated activity coefficient.

PURPOSE: Calculation of the time-integrated activity coefficient (residence time) is a crucial step in dosimetry for molecular radiotherapy. However, available software is deficient in that it is either not tailored for the use in molecular radiotherapy and/or does not include all required estimation methods. The aim of this work was therefore the development and programming of an algorithm which allows for an objective and reproducible determination of the time-integrated activity coefficient and its standard error. METHODS: The algorithm includes the selection of a set of fitting functions from predefined sums of exponentials and the choice of an error model for the used data. To estimate the values of the adjustable parameters an objective function, depending on the data, the parameters of the error model, the fitting function and (if required and available) Bayesian information, is minimized. To increase reproducibility and user-friendliness the starting values are automatically determined using a combination of curve stripping and random search. Visual inspection, the coefficient of determination, the standard error of the fitted parameters, and the correlation matrix are provided to evaluate the quality of the fit. The functions which are most supported by the data are determined using the corrected Akaike information criterion. The time-integrated activity coefficient is estimated by analytically integrating the fitted functions. Its standard error is determined assuming Gaussian error propagation. The software was implemented using MATLAB. RESULTS: To validate the proper implementation of the objective function and the fit functions, the results of NUKFIT and SAAM numerical, a commercially available software tool, were compared. The automatic search for starting values was successfully tested for reproducibility. The quality criteria applied in conjunction with the Akaike information criterion allowed the selection of suitable functions. Function fit parameters and their standard error estimated by using SAAM numerical and NUKFIT showed differences of <1%. The differences for the time-integrated activity coefficients were also <1% (standard error between 0.4% and 3%). In general, the application of the software is user-friendly and the results are mathematically correct and reproducible. An application of NUKFIT is presented for three different clinical examples. CONCLUSIONS: The software tool with its underlying methodology can be employed to objectively and reproducibly estimate the time integrated activity coefficient and its standard error for most time activity data in molecular radiotherapy.