1.
J Org Chem
; 88(12): 7849-7857, 2023 Jun 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36696680
RESUMO
In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine (3) as the amine source, asymmetric biomimetic transamination of trifluoromethyl ketones produces optically active α-trifluoromethyl amines 6 in 81-98% yields with 88-95% ee's under mild conditions.