Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34822784
2.
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
ACS Med Chem Lett
; 13(11): 1776-1782, 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385934
3.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
ACS Chem Neurosci
; 13(6): 751-765, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245037
4.
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
J Med Chem
; 63(14): 7906-7920, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558564
5.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J Med Chem
; 51(2): 196-218, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020435
6.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol Cancer Ther
; 6(4): 1198-211, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17431102
7.
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
J Med Chem
; 48(13): 4212-5, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974572
8.
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
Cancer Res
; 68(8): 2850-60, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18413753