Detalhe da pesquisa
1.
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Bioorg Med Chem
; 103: 117577, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38518735
2.
Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipidâ II.
Chembiochem
; 21(6): 789-792, 2020 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31552694
3.
Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.
Proc Natl Acad Sci U S A
; 113(35): 9691-8, 2016 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27512044
4.
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
Proc Natl Acad Sci U S A
; 111(43): E4587-95, 2014 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25267638
5.
Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase.
Chembiochem
; 16(13): 1875-1879, 2015 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147653
6.
Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.
J Am Chem Soc
; 136(5): 1922-9, 2014 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24422534
7.
A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity.
Chembiochem
; 15(15): 2216-20, 2014 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25212124
8.
Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses.
Bioorg Med Chem
; 22(17): 4836-47, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25087050
9.
Synthetic Approaches to the New Drugs Approved During 2022.
J Med Chem
; 67(6): 4376-4418, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38488755
10.
Synthetic Approaches to the New Drugs Approved During 2021.
J Med Chem
; 66(15): 10150-10201, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37528515
11.
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science
; 382(6671): eabo7201, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37943932
12.
Synthetic Approaches to the New Drugs Approved During 2020.
J Med Chem
; 65(14): 9607-9661, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35833579
13.
Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions.
J Org Chem
; 76(24): 10279-85, 2011 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22044401
14.
Synthetic Approaches to the New Drugs Approved during 2019.
J Med Chem
; 64(7): 3604-3657, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33783211
15.
Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.
J Med Chem
; 60(17): 7591-7604, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28857558
16.
A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus.
PLoS One
; 11(4): e0153912, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27101010
17.
Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules.
ACS Infect Dis
; 1(1): 53-8, 2015 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27620145