Detalhe da pesquisa
1.
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.
Bioorg Med Chem Lett
; 27(21): 4805-4811, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29029933
2.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Proc Natl Acad Sci U S A
; 110(29): E2724-32, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818614
3.
Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough.
J Clin Invest
; 132(18)2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35900863
4.
Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).
Mol Pharmacol
; 77(1): 58-68, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19805508
5.
Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.
Bioorg Med Chem Lett
; 19(11): 3063-6, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19398199
6.
The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons.
Anesth Analg
; 109(2): 632-40, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608841
7.
PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels.
Br J Pharmacol
; 175(14): 2926-2939, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29791744
8.
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Br J Pharmacol
; 175(12): 2272-2283, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29150838
9.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456800
10.
Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells.
PLoS One
; 11(8): e0161450, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27556810
11.
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
PLoS One
; 11(4): e0152405, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050761
12.
Aquaporins as targets for drug discovery.
Drug Discov Today
; 10(7): 485-93, 2005 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15809194
13.
Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation.
Br J Pharmacol
; 172(20): 4905-18, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26220736
14.
In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
Br J Pharmacol
; 143(1): 81-90, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15302680
15.
Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy.
Expert Opin Ther Pat
; 20(11): 1471-503, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20726689
16.
Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.
Expert Rev Clin Pharmacol
; 3(3): 385-96, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22111618
17.
Voltage-gated potassium channels as therapeutic targets.
Nat Rev Drug Discov
; 8(12): 982-1001, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19949402
18.
Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.
Bioorg Med Chem Lett
; 17(10): 2849-53, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350840
19.
Electrophysiological analysis of heterologously expressed Kv and SK/IK potassium channels.
Curr Protoc Pharmacol
; Chapter 11: Unit11.5, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21956802
20.
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Bioorg Med Chem Lett
; 13(10): 1741-4, 2003 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12729655