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1.
Ann Surg Oncol ; 30(12): 7157-7164, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37605083

RESUMO

BACKGROUND: Whether to sacrifice or spare the recurrent laryngeal nerve (RLN) when papillary thyroid carcinoma (PTC) involves a functioning RLN remains controversial. Oncological outcomes after shaving PTC with gross remnant on the RLN have been rarely reported. The objective of this study was to evaluate the oncological outcomes of patients who underwent shaving of a PTC from the RLN, leaving a gross residual tumor with the intent of vocal function preservation. METHODS: A retrospective, cohort study was conducted in 47 patients who were determined to have PTC invasion of the RLN via intraoperative inspection and underwent tumor shaving with macroscopic remnant (R2 resection) less than 1 cm in length and 4 mm in thickness. Median follow-up period was 93 (range, 60-215) months. The primary endpoint was the recurrence-free survival and the progression-free survival. Secondary endpoints were biochemical outcomes (serum thyroglobulin) and vocal cord function. RESULTS: Of the 47 patients, five (10.6%) patients showed recurrence (central neck, 3; lateral neck, 2) without death or distant metastasis. The RLN was resected along with the tumor in one (2.1%) patient who presented with progression of the residual tumor. Postoperative temporary vocal cord paralysis occurred in six (12.8%) patients without permanent cases. The final nonstimulated serum thyroglobulin was 0.7 ± 1.8 ng/ml. CONCLUSIONS: Shaving a tumor from a RLN with gross residual disease may be considered an alternative strategy to preserve vocal function when complete tumor resection with nerve preservation is impossible in patients with PTC invading a functioning RLN.


Assuntos
Carcinoma Papilar , Neoplasias da Glândula Tireoide , Humanos , Câncer Papilífero da Tireoide/cirurgia , Câncer Papilífero da Tireoide/patologia , Tireoglobulina , Neoplasias da Glândula Tireoide/patologia , Estudos Retrospectivos , Nervo Laríngeo Recorrente/cirurgia , Nervo Laríngeo Recorrente/patologia , Estudos de Coortes , Neoplasia Residual/patologia , Carcinoma Papilar/patologia , Tireoidectomia/efeitos adversos
2.
Graefes Arch Clin Exp Ophthalmol ; 261(4): 1127-1139, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36383278

RESUMO

PURPOSE: To describe clinical manifestations and short-term prognosis of ocular motility disorders following coronavirus disease-2019 (COVID-19) vaccination. METHODS: Ocular motility disorders were diagnosed by clinical assessment, high-resolution magnetic resonance imaging, and laboratory testing. Clinical manifestations, short-term prognosis, and rate of complete recovery were analyzed. RESULTS: Sixty-three patients (37 males, 26 females) with a mean age of 61.6 ± 13.3 years (range, 22-81 years) were included in this study. Among 61 applicable patients with sufficient information regarding medical histories, 38 (62.3%) had one or more significant underlying past medical histories including vasculopathic risk factors. The interval between initial symptoms and vaccination was 8.6 ± 8.2 (range, 0-28) days. Forty-two (66.7%), 14 (22.2%), and 7 (11.1%) patients developed symptoms after the first, second, and third vaccinations, respectively. One case of internuclear ophthalmoplegia, 52 cases of cranial nerve palsy, two cases of myasthenia gravis, six cases of orbital diseases (such as myositis, thyroid eye disease, and IgG-related orbital myopathy), and two cases of comitant vertical strabismus with acute onset diplopia were found. Among 42 patients with follow-up data (duration: 62.1 ± 40.3 days), complete improvement, partial improvement, no improvement, and exacerbation were shown in 20, 15, 3, and 4 patients, respectively. CONCLUSION: This study provided various clinical features of ocular motility disorders following COVID-19 vaccination. The majority of cases had a mild clinical course while some cases showed a progressive nature. Close follow-up and further studies are needed to elucidate the underlying mechanisms and long-term prognosis.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Miastenia Gravis , Transtornos da Motilidade Ocular , Estrabismo , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , COVID-19/diagnóstico , COVID-19/epidemiologia , Vacinas contra COVID-19/efeitos adversos , Transtornos da Motilidade Ocular/diagnóstico , Transtornos da Motilidade Ocular/etiologia , Estrabismo/diagnóstico
3.
J Korean Med Sci ; 38(12): e95, 2023 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-36974402

RESUMO

BACKGROUND: To report the clinical manifestations of non-arteritic anterior ischemic optic neuropathy (NAION) cases after coronavirus disease 2019 (COVID-19) vaccination in Korea. METHODS: This multicenter retrospective study included patients diagnosed with NAION within 42 days of COVID-19 vaccination. We collected data on vaccinations, demographic features, presence of vascular risk factors, ocular findings, and visual outcomes of patients with NAION. RESULTS: The study included 16 eyes of 14 patients (6 men, 8 women) with a mean age of 63.5 ± 9.1 (range, 43-77) years. The most common underlying disease was hypertension, accounting for 28.6% of patients with NAION. Seven patients (50.0%) had no vascular risk factors for NAION. The mean time from vaccination to onset was 13.8 ± 14.2 (range, 1-41) days. All 16 eyes had disc swelling at initial presentation, and 3 of them (18.8%) had peripapillary intraretinal and/or subretinal fluid with severe disc swelling. Peripapillary hemorrhage was found in 50% of the patients, and one (6.3%) patient had peripapillary cotton-wool spots. In eight fellow eyes for which we were able to review the fundus photographs, the horizontal cup/disc ratio was less than 0.25 in four eyes (50.0%). The mean visual acuity was logMAR 0.6 ± 0.7 at the initial presentation and logMAR 0.7 ± 0.8 at the final visit. CONCLUSION: Only 64% of patients with NAION after COVID-19 vaccination have known vascular and ocular risk factors relevant to ischemic optic neuropathy. This suggests that COVID-19 vaccination may increase the risk of NAION. However, overall clinical features and visual outcomes of the NAION patients after COVID-19 vaccination were similar to those of typical NAION.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Neuropatia Óptica Isquêmica , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vacinas contra COVID-19/efeitos adversos , Neuropatia Óptica Isquêmica/diagnóstico , Neuropatia Óptica Isquêmica/epidemiologia , Neuropatia Óptica Isquêmica/etiologia , República da Coreia/epidemiologia , Estudos Retrospectivos , Tomografia de Coerência Óptica
4.
Am J Otolaryngol ; 43(6): 103560, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36029620

RESUMO

PURPOSE: Palatal surgery remains a major option for patients with obstructive sleep apnea (OSA). We sought to evaluate the therapeutic outcomes of the palatopharyngeal muscle suspension suture technique (PSST) as a novel palatal surgery for patients with OSA. MATERIALS AND METHODS: Of the 816 patients who underwent polysomnography (PSG) from February 1, 2017, to June 30, 2020, 30 patients with OSA who underwent PSST were retrospectively reviewed. The medical records of the patients were also recorded. Among the 30 patients with OSA, nine who underwent preoperative and postoperative PSG were analyzed. RESULTS: Of the 30 patients with OSA, 28 (93.3 %) were male. The mean (SD, standard deviation) age was 43.3 (12.7) years, and the mean (SD) body mass index was 27.3 (3.2). As objective parameters, the mean (SD) apnea-hypopnea index was significantly decreased from 45.9 (21.20) to 29.03 (21.62) (p < 0.05) and the mean (SD) lowest oxygen saturation improved significantly from 77.6 % (7.14 %) to 84.6 (5.17 %) (p < 0.05). As a subjective parameter, the mean (SD) Epworth Sleepiness Scale score decreased significantly from 10 (4.95) to 6.9 (4.57) (p < 0.05), and the mean (SD) visual analog scale score for snoring decreased significantly from 6.3 (1.8) to 3.1 (1.9) (p < 0.001). No complications, such as upper airway obstruction, intractable postoperative bleeding, or velopharyngeal insufficiency, were observed in any of the patients postoperatively. CONCLUSIONS: A novel palatal surgery, PSST, has numerous advantages as a useful surgical option for patients with OSA. It is minimally invasive, easy, time-saving, and relatively reversible.


Assuntos
Apneia Obstrutiva do Sono , Humanos , Masculino , Adulto , Feminino , Estudos Retrospectivos , Resultado do Tratamento , Apneia Obstrutiva do Sono/cirurgia , Técnicas de Sutura , Músculos Faríngeos/cirurgia
8.
Graefes Arch Clin Exp Ophthalmol ; 256(5): 1005-1010, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29305730

RESUMO

PURPOSE: To evaluate the early postoperative changes of the angle of deviation after surgery for intermittent exotropia. METHODS: We retrospectively reviewed the medical records of 114 patients who had been surgically treated for intermittent exotropia and followed-up on postoperatively for 1 month or more. Patients were observed at postoperative 6 h, 1 day, 1 week, and 1 month. The main outcome measure was the change of the angle of deviation during the early postoperative period (from 6 h to 1 day postoperatively). RESULTS: The mean preoperative angle of exodeviation was 26.3 ± 7.6 PD at distance and 25.4 ± 10.3 PD at near. The angle of deviation was -3.3 (esodeviation) ± 7.0 PD at distance and -0.7 ± 7.1 PD at near at postoperative 6 h, and -3.7 ± 6.9 PD and -0.8 ± 6.8 PD at postoperative 1 day. Neither of these sets represented a significant change from 6 h to 1 day postoperatively (p = 0.300 at distance, p = 0.945 at near). However, in 25 patients (21.9%) the angle of deviation changed 5 PD or more from 6 h to 1 day. Among them, ten showed exodrift and 15 esodrift. At postoperative 1 month, the deviations became significantly more exotropic compared with postoperative 1 day (p < 0.001). CONCLUSIONS: The mean angle of deviation showed no significant change from 6 h to 1 day postoperatively, but 21.9% of patients showed a change of 5 PD or more in this period. These results should be considered in determining the time and the target angle of adjustment in adjustable strabismus surgery for exotropia.


Assuntos
Exotropia/cirurgia , Músculos Oculomotores/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Exotropia/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Músculos Oculomotores/fisiopatologia , Período Pós-Operatório , Estudos Retrospectivos , Resultado do Tratamento , Visão Binocular/fisiologia , Adulto Jovem
9.
Graefes Arch Clin Exp Ophthalmol ; 255(12): 2487-2492, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28889226

RESUMO

PURPOSE: To evaluate the level of stereopsis and fusion in patients with anisometropia according to the presence of amblyopia. METHODS: We included 107 children with anisometropia, divided into groups with non-amblyopic anisometropia (NA, n = 72) and amblyopic anisometropia (AA, n = 35). Normal subjects without anisometropia were enrolled in the control group (n = 73). Main outcome measures were the level of stereopsis and sensory fusion as evaluated by Titmus stereotest and Worth 4-dot test, respectively, using anisometropic glasses. RESULTS: The degree of anisometropia in the NA, AA, and control groups was 2.54 diopters (D), 4.29 D, and 0.30 D, respectively (P = 0.014). Stereopsis (arcsec) was significantly worse in the AA group than the NA and control groups (641.71, 76.25, 54.52, respectively, P < 0.001), while no significant difference was found between the NA and control groups. The rate of fusion was significantly lower in the AA than the NA group (14.3% vs. 65.3%, P < 0.001), and was significantly lower in the NA than the control group (65.3% vs. 80.6%, P = 0.001). CONCLUSIONS: The levels of stereopsis and sensory fusion with anisometropic glasses were significantly worse in the AA than in the NA group. The level of stereopsis in the NA group, however, did not differ significantly from that in the isometropic control, while the rate of fusion was significantly lower. Early prescription of anisometropic glasses is needed to improve visual acuity and binocularity in children with possible amblyopic anisometropia.


Assuntos
Ambliopia/fisiopatologia , Anisometropia/fisiopatologia , Percepção de Profundidade/fisiologia , Fusão Flicker/fisiologia , Visão Binocular/fisiologia , Acuidade Visual , Adolescente , Ambliopia/diagnóstico , Ambliopia/terapia , Anisometropia/diagnóstico , Anisometropia/terapia , Criança , Pré-Escolar , Óculos , Feminino , Humanos , Masculino , Estudos Retrospectivos , Testes Visuais
10.
BMC Ophthalmol ; 17(1): 130, 2017 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-28738831

RESUMO

BACKGROUND: To analyze the surgical outcomes for patients diagnosed with acquired nonaccommodative esotropia (ANAET). METHODS: In this retrospective study, the medical records of 35 patients who had undergone the surgery for ANAET with a postoperative follow-up period of 6 months or more were reviewed. The main outcome measures were postoperative esodeviation angle, final success rate, and factors affecting surgical outcome. Surgical success was considered to be an alignment within 8 prism diopters (PD) at distance and near. RESULTS: The preoperative mean esodeviation angles were 37.3 ± 13.7 PD at distance and 38.6 ± 16.6 PD at near. The postoperative mean esodeviation angles at distance were as follows: 4.2 PD at day 1, 4.0 PD at month 1, 3.9 PD at month 3, 4.9 PD at month 6, 4.7 PD at year 1, and 4.8 PD at final follow-up. There was no statistically significant difference in angle of esodeviation between the initial postoperative period (day 1 to month 6) and the final follow-up day (p > 0.05). The surgical success rate at final follow-up was 65.7% (23/35). Among the 12 patients for whom the surgery failed, 9 (24.3%) showed esotropia and 3 (8.1%) exotropia of more than 8 PD. Six patients (16.2%) underwent reoperation (4 for esotropia and 2 for exotropia). There was no factor influencing surgical outcome (p > 0.05). CONCLUSIONS: The surgical outcome in patients with ANAET was relatively favorable: the final success rate was 65.7% and the reoperation rate was 17.1%.


Assuntos
Acomodação Ocular , Esotropia/cirurgia , Músculos Oculomotores/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Visão Binocular/fisiologia , Acuidade Visual , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Esotropia/fisiopatologia , Feminino , Seguimentos , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Músculos Oculomotores/fisiopatologia , Período Pós-Operatório , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
11.
BMC Ophthalmol ; 17(1): 117, 2017 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-28679404

RESUMO

BACKGROUND: The aim of this study was to compare the primary surgery and reoperation outcomes of unilateral lateral rectus recession and medial rectus resection (R&R) for intermittent exotropia. METHODS: We retrospectively reviewed the medical records of 80 patients, all of whom had undergone unilateral R&R for intermittent exotropia as a primary surgery or reoperation and been followed-up on postoperatively for 6 months or more. The patients were divided into two groups: unilateral R&R as primary surgery (group A, 44 patients) and unilateral R&R as reoperation (group B, 36 patients). The outcome measures were postoperative angle of deviation, surgical success rate, and mean dose-effect ratio (PD/mm, corrected angle of deviation / sum of amount of recession of lateral rectus and of resection of medial rectus). Surgical success was defined as exo- or esodeviation within 8 PD. RESULTS: The mean postoperative follow-up duration was 49.91 ± 14.83 months in group A and 43.17 ± 26.91 months in group B (p = 0.160). The mean angles of deviation at postoperative 1 day were -5.18 PD (overcorrection) in group A and -5.28 PD in group B (p = 0.932). However, there was a significant difference in the mean angle of deviation between the two groups at each visit from postoperative 3 months to final follow-up (p < 0.05): in short, group A had become more exotropic than group B. And the surgical success rate was higher in group B than in group A at each visit from postoperative 12 months to final follow-up (47.7% in group A and 83.3% in group B at final follow-up) (p < 0.05). The mean dose-effect ratio at 6 months after surgery was 1.89 ± 0.58 PD/mm in group A and 2.26 ± 0.32 PD/mm in group B (p = 0.001). CONCLUSIONS: Unilateral R&R as reoperation presented better results for the surgical treatment of recurrent exotropia, showing a smaller exodrift pattern and higher surgical success rates compared with R&R as a primary surgery. The mean effect per millimeter (the mean dose-effect ratio, PD/mm) of R&R as reoperation was significantly greater than that of R&R as primary surgery at postoperative 6 months. These results could serve as useful guidelines in the planning of surgical correction for primary and recurrent exotropia.


Assuntos
Exotropia/cirurgia , Movimentos Oculares/fisiologia , Músculos Oculomotores/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Visão Binocular , Pré-Escolar , Doença Crônica , Exotropia/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Músculos Oculomotores/fisiopatologia , Período Pós-Operatório , Recidiva , Reoperação , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento
12.
BMC Ophthalmol ; 16: 97, 2016 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-27391365

RESUMO

BACKGROUND: The aim of this study was to investigate the type of exotropia (XT) based on the distance-near (D/N) difference in recurrent XT after bilateral lateral rectus (BLR) recession to treat intermittent XT (IXT) to look into the possibility of secondary convergence insufficiency (CI)-type strabismus. METHODS: A total of 121 patients with recurrent XT after BLR recession for basic-type and divergence excess (DE)-type IXT were retrospectively enrolled at a single institution. The distributions in the XT types were compared according to the D/N difference between primary and recurrent XT. RESULTS: Preoperatively, the population comprised 14 divergence excess (DE) types and 107 basic types. After the BLR recession, the XT-type composition changed to 59 basic types, 33 CI types, and 29 DE types. In one of the 14 preoperatively identified DE-type XT cases, the XT type changed to CI type, it changed to basic type in four cases, and the remaining nine cases showed no change in the DE type. The 107 preoperatively identified basic-type XT cases postoperatively became 55 basic-type, 32 CI-type, and 20 DE-type recurrent XT cases, and their postoperative distance XT control grades and near stereoacuity values did not significantly differ. CONCLUSION: The XT type composition changed after the BLR recession. The XT types in recurrent XT after BLR recession showed an increasing proportion of CI-type. We suspect that an individual fusion mechanism might also influence the XT-type in recurrent XT in view of the somewhat increased DE-type in recurrent XT.


Assuntos
Exotropia/cirurgia , Músculos Oculomotores/cirurgia , Procedimentos Cirúrgicos Oftalmológicos , Criança , Pré-Escolar , Convergência Ocular/fisiologia , Exotropia/diagnóstico , Exotropia/fisiopatologia , Feminino , Seguimentos , Humanos , Modelos Logísticos , Masculino , Recidiva , Estudos Retrospectivos , Acuidade Visual/fisiologia
13.
Sex Transm Dis ; 42(6): 345-6, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25970315

RESUMO

We describe an unusual case of hemorrhagic exudative optic neuropathy as an initial presentation of neurosyphilis in an immunocompetent patient. The clinicians have to be alert to consider a diagnosis of syphilitic optic neuropathy in cases with hemorrhagic exudative optic neuropathy.


Assuntos
Antibacterianos/uso terapêutico , Neurossífilis/diagnóstico , Disco Óptico/patologia , Nervo Óptico/patologia , Neurite Óptica/diagnóstico , Penicilina G/uso terapêutico , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neurossífilis/microbiologia , Neurossífilis/patologia , Neurite Óptica/microbiologia , Neurite Óptica/patologia , Resultado do Tratamento
14.
BMC Ophthalmol ; 14: 46, 2014 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-24708678

RESUMO

BACKGROUND: The purpose of this study was to compare surgical outcomes of unilateral lateral rectus recession (ULR) and unilateral recess-resect (RR) for intermittent exotropia of 20-25 prism diopters (PD). METHODS: In this retrospective study, ULR was performed on 82 patients and RR on 98 patients for the treatment of intermittent exotropia of 20-25 PD with a follow-up period of 24 months or more. The main outcome measures were postoperative exodeviation angles and final success rates. A surgical success was considered to be an alignment within 10 PD. RESULTS: The mean follow-up duration after the surgery was 53.8 ± 26.4 months in the ULR group and 52.5 ± 27.4 months in the RR group (p = 0.482). The mean deviation angles at postoperative 1 day were -0.49 PD (esodeviation) in the ULR group and -1.98 PD in the RR group. Subsequently, at postoperative 1 week, 1 and 3 months, the deviations became more exotropic in the ULR group than in the RR group (p < 0.05). However, the mean deviation angles at 6 months, 1 and 2 years and at the final follow-up did not significantly differ between the two groups. Surgical success at the final follow-up was achieved for 50 patients (60.9%) in the ULR group and 55 patients (56.1%) in the RR group (p = 0.511). CONCLUSIONS: ULR is an effective surgical method for treatment of moderate-angle intermittent exotropia of 20-25 PD, showing results similar to those of RR.


Assuntos
Exotropia/cirurgia , Músculos Oculomotores/cirurgia , Criança , Pré-Escolar , Percepção de Profundidade/fisiologia , Exotropia/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Procedimentos Cirúrgicos Oftalmológicos/métodos , Estudos Retrospectivos , Acuidade Visual/fisiologia
15.
Acta Ophthalmol ; 102(3): e339-e345, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-37688371

RESUMO

PURPOSE: This study aimed to compare the periods for exodrift stabilization and the long-term surgical outcomes among different surgical methods in intermittent exotropia. METHODS: The medical records of 350 patients who had undergone intermittent exotropia correcting surgery [unilateral lateral rectus recession-medial rectus resection (R&R, n = 221), bilateral lateral rectus recession (BLR, n = 51) and unilateral lateral rectus recession (ULR, n = 78)] with a postoperative follow-up period of 1.5 years or more were retrospectively reviewed. The deviation angles every 6 months after surgery, periods of exodrift stabilization and surgical outcomes were analysed. The period of postoperative exodrift stabilization was defined as when exodrift was no longer significantly different from that at the next visit (p > 0.05). An alignment of 5 PD (prism diopters) esotropia to 10 PD exotropia at a distance and near fixation was considered surgical success. RESULTS: The mean angle of exodeviation was significantly different among surgical procedures at postoperative 1 month (BLR > ULR > R&R, p < 0.001); however, there were no differences among the procedures at 6 months (p = 0.088). The periods of exodrift stabilization were 6 months after ULR, 1 year after BLR and 4.5 years after R&R. The surgical success and reoperation rates did not show significant differences among procedures at the final follow-up. CONCLUSION: Patients undergoing R&R showed smaller exodeviation shortly after surgery but required a longer period to stabilize the exodrift. Following ULR, exodeviation was larger in the early postoperative period, but the exodrift was stabilized earlier. Therefore, the long-term surgical outcomes were similar among ULR, BLR and R&R.


Assuntos
Exotropia , Humanos , Seguimentos , Exotropia/cirurgia , Estudos Retrospectivos , Visão Binocular , Procedimentos Cirúrgicos Oftalmológicos/métodos , Músculos Oculomotores/cirurgia , Período Pós-Operatório , Doença Crônica , Resultado do Tratamento
16.
PLoS One ; 18(4): e0284112, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37014902

RESUMO

PURPOSE: In patients with strabismus, the stereopsis and Worth 4-dot (W4d) tests have often been used to evaluate whether sensory fusion is achieved. However, if patients face difficulties undergoing the Titmus or W4d test because of poor visual acuity (VA) due to refractive error abnormalities, the results of these tests cannot be appropriately interpreted. Therefore, we evaluated the correlation between distance uncorrected VA (UCVA) and sensory status in children with reduced VA due to refractive error abnormalities to identify the effects of refractive errors on sensory test results. METHODS: We retrospectively reviewed the medical records of 195 children with reduced VA with VA improvement ≥ 20/25, Titmus stereoacuity ≤ 50 arcsec, and fusion in the W4d result after refractive error correction with spectacles. We evaluated the correlation between distance UCVA in logMAR and sensory status measured by the near Titmus stereotest and distance W4d test. Additionally, the minimum required UCVA for interpreting Titmus or W4d results was assessed using a receiver operating characteristic (ROC) curve. RESULTS: The UCVA showed a marginal but non-significant correlation with Titmus stereoacuity (p = 0.053) and a significant correlation with fusion in W4d (p < 0.001). The ROC curve analysis showed an optimal cut-point value of VA required for interpreting the results of W4d test as 0.3 logMAR (20/40 in Snellen acuity). CONCLUSIONS: Correcting refractive error in advance may help appropriately interpret sensory status in school-aged children with reduced VA due to refractive error abnormalities.


Assuntos
Basidiomycota , Erros de Refração , Humanos , Criança , Estudos Retrospectivos , Percepção de Profundidade , Acuidade Visual , Transtornos da Visão
17.
Sci Rep ; 13(1): 4066, 2023 03 11.
Artigo em Inglês | MEDLINE | ID: mdl-36906702

RESUMO

This retrospective study evaluated long-term visual outcomes in children with regressed retinopathy of prematurity (ROP) and correlations between visual acuity (VA) and clinical variables, including fundus findings. We reviewed the medical records of 57 consecutive patients diagnosed with ROP. We analyzed the correlations between best-corrected VA and anatomical fundus findings, such as macular dragging and retinal vascular tortuosity, after ROP regression. The correlations between VA and clinical variables such as gestational age (GA), birth weight (BW), and refractive errors (hyperopia and myopia in spherical equivalent [SE], astigmatism, and anisometropia) were also evaluated. Of 110 eyes, 33.6% had macular dragging; the presence of macular dragging and poor VA were significantly correlated (p = 0.002). Patients with larger macula-to-disc distance/disc diameter ratios had significantly poorer VA (p = 0.036). However, no significant correlation was observed between the VA and vascular tortuosity. Patients with smaller GA and BW had poorer visual outcomes (both, p = 0.007). The larger SE in absolute values, myopia, astigmatism, and anisometropia were significantly associated with poorer visual outcomes as well (all, p < 0.001). In children with regressed ROP, macular dragging, small GA and BW, large SE in absolute values, myopia, astigmatism, and anisometropia may be predictors of poor visual outcomes at early ages.


Assuntos
Anisometropia , Astigmatismo , Miopia , Retinopatia da Prematuridade , Humanos , Recém-Nascido , Anisometropia/complicações , Astigmatismo/complicações , Peso ao Nascer , Idade Gestacional , Recém-Nascido Prematuro , Miopia/complicações , Retinopatia da Prematuridade/diagnóstico , Estudos Retrospectivos
18.
Sci Rep ; 13(1): 1329, 2023 01 24.
Artigo em Inglês | MEDLINE | ID: mdl-36693891

RESUMO

The Korean Intermittent Exotropia Multicenter Study (KIEMS) was a retrospective, cross-sectional and multicenter study for the investigation of intermittent exotropia involved 65 strabismus specialists from 53 institutions in Korea. Purpose of this study was to present ophthalmologic findings of intermittent exotropia from the KIEMS. Consecutive patients with intermittent exotropia of ≥ 8 prism diopters (PD) at distance or near fixation were included. Best-corrected visual acuity, cycloplegic refraction data, angles of deviation at several cardinal positions, ocular dominance, fusion control, oblique muscle function, and binocular sensory outcomes were collected. A total of 5385 participants (2793 females; age 8.2 years) were included. Non-dominant eye was more myopic than the dominant eye (- 0.60 vs. - 0.47 diopters, P < 0.001). Mean exodeviation angles were 23.5 PD at distance and 25.0 PD at near fixation. Basic type (86.2%) was the most, followed by convergence insufficiency (9.4%) and divergence excess (4.4%) types. Alternating ocular dominance and good fusion control were more common at near than at distance fixation. Good stereopsis at 40 cm was observed in 49.3% in Titmus stereo test (≤ 60 arcsec) and in 71.0% in Randot stereo test (≤ 63 arcsec). Intermittent exotropia was mostly diagnosed in childhood and patients with the condition showed relatively good binocular functions. This study may provide objective findings of intermittent exotropia in a most reliable way, given that the study included a large study population and investigated comprehensive ophthalmology examinations.


Assuntos
Exotropia , Oftalmologia , Feminino , Humanos , Criança , Exotropia/cirurgia , Estudos Transversais , Estudos Retrospectivos , População do Leste Asiático , Procedimentos Cirúrgicos Oftalmológicos , Visão Binocular/fisiologia
19.
Ophthalmology ; 119(5): 965-71, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22330961

RESUMO

PURPOSE: To investigate whether ethanol administration disturbs the tear film and ocular surface. DESIGN: Case-control study. PARTICIPANTS: Twenty healthy male subjects were recruited. Ethanol was administered to 10 subjects and another 10 subjects served as controls. METHODS: Twenty healthy male subjects with no ocular disease were recruited. Ethanol (0.75 g/kg) was administered orally at 8 pm for 2 hours to 10 subjects. MAIN OUTCOME MEASURES: The tear film and ocular surface were evaluated at 6 pm before drinking, at midnight, and immediately (6 am) and 2 hours (8 am) after waking the next morning. Tear osmolarity, ethanol concentration in tears and serum, Schirmer's test results, tear film break-up time (TBUT), corneal punctuate erosion, and corneal sensitivity were measured. RESULTS: Ethanol was detected in tears and serum at midnight, but it was not detected the next morning. The mean tear osmolarity level increased in the alcohol group at midnight compared with that in the control group (P<0.001). The alcohol group showed a significantly shorter TBUT compared with the control group after drinking alcohol (P<0.001 at 12 am, P<0.001 at 6 am, and P = 0.002 at 8 am). There were significantly higher fluorescein staining scores in the alcohol group compared with those in the control group at 6 am and 8 am (P = 0.001 and P<0.001, respectively). No significant change was shown in corneal sensitivity or Schirmer's test results in either group. CONCLUSIONS: Orally administered ethanol was secreted into the tears. Ethanol in tears induced tear hyperosmolarity and shortened TBUT and triggered the development of ocular surface diseases. Similar changes could exacerbate signs and symptoms in patients with ocular surface disease.


Assuntos
Consumo de Bebidas Alcoólicas/efeitos adversos , Doenças da Córnea/etiologia , Síndromes do Olho Seco/etiologia , Etanol/sangue , Lágrimas/efeitos dos fármacos , Administração Oral , Adulto , Índice de Massa Corporal , Estudos de Casos e Controles , Córnea/fisiologia , Doenças da Córnea/sangue , Doenças da Córnea/fisiopatologia , Síndromes do Olho Seco/sangue , Síndromes do Olho Seco/fisiopatologia , Fluorofotometria , Humanos , Masculino , Concentração Osmolar , Lágrimas/metabolismo , Adulto Jovem
20.
Sci Rep ; 12(1): 8591, 2022 05 21.
Artigo em Inglês | MEDLINE | ID: mdl-35597850

RESUMO

To determine the efficacy of unilateral lateral rectus recession (ULR) for convergence insufficiency-type intermittent exotropia (CI-type IXT), we compared surgical outcomes following ULR and recess‒resect (RR) procedures for CI-type IXT. In this retrospective study, medical records of 57 children who underwent ULR (n = 30) or RR (n = 27) for CI-type IXT of less than 25 PD at distance with a postoperative follow-up of 6 months or more were reviewed. Surgical success was defined as an alignment between 10 PD exodeviation and 5 PD esodeviation at distance and near fixation. The postoperative exodeviation showed no significant difference between the two groups at the last follow-up. A significant reduction in the mean near-distance difference was achieved postoperatively in both groups: from 5.4 PD preoperatively to 2.5 at last follow-up after ULR, and from 8.2 to 2.4 after RR (both p = 0.001). However, this difference between ULR and RR was not statistically significant (p > 0.05). The success rate at the last follow-up was 63.3% for ULR and 70.4% for RR (p = 0.574). ULR was found to be an effective treatment for CI-type IXT, with similar surgical outcomes to RR.


Assuntos
Exotropia , Transtornos da Motilidade Ocular , Criança , Doença Crônica , Exotropia/cirurgia , Seguimentos , Humanos , Procedimentos Cirúrgicos Oftalmológicos/métodos , Estudos Retrospectivos , Resultado do Tratamento , Visão Binocular
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