Characterization of a Vigorous sucking style in early infancy and its predictive value for weight gain and eating behaviors at 12 months.

This study sought to identify sucking profiles among healthy, full-term infants and assess their predictive value for future weight gain and eating behaviors. Pressure waves of infant sucking were captured during a typical feeding at age 4 months and quantified via 14 metrics. Anthropometry was measured at 4 and 12 months, and eating behaviors were measured by parent report via the Children's Eating Behavior Questionnaire-Toddler (CEBQ-T) at 12 months. Sucking profiles were created using a clustering approach on the pressure wave metrics, and utility of these profiles was assessed for predicting which infants will have weight-for-age (WFA) percentile changes from ages 4-12 months that exceed thresholds of 5, 10, and 15 percentiles, and for estimating each CEBQ-T subscale score. Among 114 infants, three sucking profiles were identified: Vigorous (51%), Capable (28%), and Leisurely (21%). Sucking profiles were found to improve estimation of change in WFA from 4 to 12 months and 12-month maternal-reported eating behaviors above infant sex, race/ethnicity, birthweight, gestational age, and pre-pregnancy body mass index alone. Infants with a Vigorous sucking profile gained significantly more weight during the study period than infants with a Leisurely profile. Infant sucking characteristics may aid in predicting which infants may be at greater risk of obesity, and therefore sucking profiles deserve more investigation.

Sensitization of the reinforcing value of high energy density foods is associated with increased zBMI gain in adolescents.

BACKGROUND/OBJECTIVES: Characterizing behavioral phenotypes that predict increased zBMI gain during adolescence could identify novel intervention targets and prevent the development of obesity. The purpose of this study was to determine if sensitization of the relative reinforcing value (RRV) of high (HED) or low energy density (LED) foods predicts adolescent weight gain trajectories. A secondary aim was to test the hypothesis that relationships between sensitization of the RRV of food and weight change are moderated by delay discounting (DD). SUBJECTS/METHODS: We conducted a prospective, longitudinal cohort study in 201 boys and girls with an average zBMI of 0.4, who began the study between the ages of 12 and 14 years and completed the study 2 years later. Participants completed five laboratory visits where the RRV of HED and LED, and DD were assessed at a baseline (visits 1, 2, and 4) and then RRV was measured again after participants consumed a portion of the same HED and LED food for 2 weeks (visits 3 and 5; order counterbalanced). Increases (>1) in the RRV from baseline to post-daily intake were categorized as "sensitization" and decreases (≤1) were categorized as "satiation." Participants returned to the laboratory for follow-up visits at 6, 15, and 24 months to have height and weight taken and to complete additional assessments. RESULTS: Sensitization to HED food was associated with a greater zBMI change over time (ß = 0.0070; p = 0.035). There was no impact of sensitization to LED food or interaction between sensitization to HED and LED food on zBMI change and no moderation of DD on the relationship between HED sensitization and zBMI change (all p > 0.05). CONCLUSION: Our prior work showed that sensitization to HED food is cross-sectionally associated with greater zBMI. This study extends this work by demonstrating that sensitization to HED food prospectively predicts increased zBMI gain over time in adolescents without obesity. Future studies should determine if sensitization can be modified or reduced through behavioral intervention. TRIAL REGISTRATION: Clinicaltrials.gov: NCT04027608.

The effect of food insecurity and stress on delay discounting across families: a COVID-19 natural experiment.

BACKGROUND: Delay Discounting is the extent to which one prioritizes smaller immediate rewards over larger, delayed rewards. The ability to prospect into the future is associated with better health decision-making, which suggests that delay discounting is an important intervention target for the prevention and treatment of chronic disease. Delay discounting decreases throughout development and stressful experiences, particularly those that accompany poverty, may influence this developmental trajectory. The current study leveraged the COVID-19 pandemic and resulting economic downturn as a natural experiment to understand how changes in food insecurity and psychological stress may associated with changes in delay discounting among parents, adolescents, and children. METHODS: A stratified cohort of families (N = 76 dyads), established prior to the initial pandemic lockdowns, were asked to complete a follow-up survey in the summer of 2020, during reopening. Thirty-seven (49%) families had an older adolescent (aged 15 - 18 years) in the study and 39 (51%) had an elementary aged child (aged 7 - 12 years) in the follow-up study. Both data collection points included measurements of economic position, psychological stress, food security status, and delay discounting. RESULTS: The results showed that pandemic food insecurity was associated with greater stress among parents (ß = 2.22, t(65.48) = 2.81, p = 0.007). Parents, Adolescents, and children significantly differed in their response to psychological stress during the pandemic (ß = -0.03, t(102.45) = -2.58, p = 0.011), which was driven by a trend for children to show greater delay discounting associated with an increase in psychological stress during the pandemic (ß = -0.01, p = 0.071), while adolescents and parents showed no change. CONCLUSIONS: These findings add to the evidence that food insecurity is uniquely stressful among parents with no effects on delay discounting. Despite this, we found no evidence that food insecurity was stressful for child or adolescents. A trend in our data suggested that childhood, as compared with adolescence, may be an important developmental period for the association between stress and delay discounting. Future research should continue the longitudinal investigation of childhood stress and the developmental trajectory of delay discounting to ascertain how these effects may persist in adulthood.

Having less and wanting more: an investigation of socioeconomic status and reinforcement pathology.

BACKGROUND: In the United states obesity and socioeconomic status (SES), or one's standing in society based on income, education, and/or occupation, are strongly associated. The mechanisms for this relationship may include having high levels of motivation to get food (reinforcing value of food; RRV) and low levels of inhibitory control (delay discounting; DD) which, when combined, is referred to as reinforcement pathology (RP). We sought to examine the relationships among multiple measures of household SES, RP, and age-adjusted body mass index (zBMI) among adolescents. METHODS: These data were collected as part of ongoing longitudinal study of risk factors for obesity in 244 adolescents. The adolescents and one parent/guardian had height and weight measured and completed surveys. The adolescents completed an adjusting amount DD task and a computer-based RRV task. Analyses consisted of correlations among measures of SES and RRV, DD, and BMI z-scores. In the case of significant associations, multiple regression models were created with theoretically informed covariates. RESULTS: Household income, parent/guardian education, parent/guardian occupation, and food insecurity status were all related to one another. Among the adolescents, a significant portion of the variance in RRV was accounted for by household income after controlling for covariates. For DD, it was parent/guardian education that was most associated after controlling for covariates. CONCLUSION: When low income and low parent/guardian education occur together, there may be an increased risk of RP. Separately, food insecurity was predictive of higher parent/guardian BMI. Future research should continue to explore the effects of low income and parent/guardian education on RP among youth by examining them over time.

Sensitization of the reinforcing value of food: a novel risk factor for overweight in adolescents.

BACKGROUND AND OBJECTIVES: The relative reinforcing value (RRV) of food is associated with increased energy intake and obesity and increases in RRV of food after repeated intake (sensitization) are related cross-sectionally and prospectively to higher BMI in adults. We examined the factors, such as delay discounting (DD), associated with sensitization of RRV to high energy density (HED) and low energy density (LED) food and how sensitization relates to zBMI in adolescents. We hypothesized that sensitization to HED food would be positively associated with zBMI, that sensitization to LED food would be negatively associated with zBMI, that DD would be associated with HED sensitization, and that LED sensitization and DD would moderate the relationships between HED sensitization and zBMI. SUBJECTS AND METHODS: A population-based sample of 207 adolescents without obesity, aged 12-14 years was studied from June 2016-March 2019. The RRV of LED and HED foods were measured before and after two weeks of daily consumption along with zBMI and other potential factors related to eating and weight, including dietary restraint, hunger, food liking, and delay discounting (DD). Hierarchical regression models were used to determine the associations between these factors and sensitization and zBMI. We also examined LED sensitization and DD as potential moderators of the relationship between sensitization and zBMI. RESULTS: As hypothesized, dietary restraint and sensitization to HED food were associated with greater zBMI. Contrary to our original hypotheses, DD was not associated with sensitization, there was no relationship between sensitization to LED food and zBMI and neither LED sensitization or DD moderated the relationship between HED sensitization and zBMI. CONCLUSIONS: Sensitization to repeated intake of HED food was associated with higher zBMI in adolescents without obesity. Sensitization may be a novel behavioral phenotype that may relate to overweight in youth.

The association of food insecurity with the relative reinforcing value of food, BMI, and gestational weight gain among pregnant women.

OBJECTIVE: Food insecurity is associated with obesity among adults. During pregnancy, food insecurity increases obesity risk among mothers and infants. This study investigated the association of food security with pre-pregnancy body mass index (BMI), gestational weight gain (GWG) adequacy to date, and the relative reinforcing value (RRV) of food during pregnancy. METHODS: This secondary data analysis examined 258 pregnant women (mean gestational age = 21.21 ± 10.21 weeks) surveyed on pre-pregnancy weight, height, pregnancy due date and GWG to date, current diagnoses related to eating and pregnancy, and demographics. The survey also assessed current food security and RRV of meals, snacks, cognitive activities, and active activities. BMI was calculated from pre-pregnancy height and weight (kg/m2). Gestational weight gain adequacy to date was derived from the Institute of Medicine guidelines. Multivariable linear regression models were used to examine the relation of food security with pre-pregnancy BMI and RRVs of foods/activities. The relation between food security and GWG adequacy to date was examined using multinomial regression models. RESULTS: Lower food security was related to both greater pre-pregnancy BMI (ß = 0.60, p < .001) and greater RRV of snack foods (ß = 3.46, p < .05), after controlling for covariates. Lower food security was also related to GWG to date below recommended levels (OR = 1.25, p < .05). CONCLUSIONS: Food insecurity is related to higher relative food reinforcement during pregnancy, and greater pre-pregnancy weight status. Future research should replicate and extend these findings by assessing them longitudinally to better evaluate the directions of these relationships.

The relationships between eating disorder pathology and relative reinforcing value of food, delay discounting, and related constructs in adolescents.

Food is a primary reinforcer that motivates behavior in the absence of learning or conditioning. Both the relative reinforcing value (RRV) of food and delay discounting are associated with weight status. While dietary restraint and disinhibition have been shown to influence the RRV of food, limited work has examined the relationships between eating disorder pathology and RRV of food and delay discounting. Therefore, the purpose of this study was to examine how eating disorder pathology predicts RRV of food, proportion of food consumed, delay discounting, reinforcement pathology (i.e., high motivation to eat and high delay discounting), and sensitization of high energy dense food (HED; i.e., increases in RRV of HED food after daily repeated exposure). Participants were 167 adolescents ages 12-14 without obesity participating in a longitudinal study examining predictors of weight change who completed a series of laboratory assessments assessing the RRV of food of HED food, delay discounting, reinforcement pathology, sensitization of HED food, and a questionnaire assessing eating disorder pathology. Eating disorder pathology was not related to the RRV of food or delay discounting, but did predict reinforcement pathology and the sensitization of HED food. When explored by weight status, these relationships were only observed for those with overweight. There were no other significant relationships for either adolescents with normal weight or overweight. Given that weight status appeared to moderate some of the relationships between eating disorder pathology and reinforcement-related constructs, future work should examine how reinforcement pathology and eating disorder pathology are related to changes in weight status over time.

Experimental scarcity increases the relative reinforcing value of food in food insecure adults.

People with fewer financial resources are at greater risk for obesity, but the mechanisms of this relationship are not fully understood. One factor that is related, both cross-sectionally and prospectively, to obesity is the relative reinforcing value of food. It is possible that the experience of scarcity increases this reinforcing value. To date, no studies have examined this potential relationship experimentally in humans. The purpose of the studies presented here was to test the hypothesis that experimental manipulations of perceived scarcity would impact the relative reinforcing value of food. A secondary hypothesis was that individuals who report experiencing food insecurity would be more sensitive to these experimental manipulations. In order to test these hypotheses, we investigated the effects of experimentally manipulated scarcity on the relative reinforcing value of food in a laboratory setting. Study 1 had a within-subjects design and included 25 adults. Scarcity was manipulated by placing time and resource limits on the relative reinforcing value task and examining responding for a high calorie snack food versus that of an alternative reinforcer. Study 1 showed a tendency for food insecure participants to respond more for all reinforcers across conditions and have a higher proportional response for food when resources were limited. Study 2 also made use of a within-subjects design with 30 adults and primed scarcity by creating financial gains and losses on the Iowa Gambling Task. We observed higher relative reinforcing values of food among food insecure participants in the control condition, which decreased in the financial gain condition. When taken together, these two studies suggest that individuals who report experiencing food insecurity respond to acute manipulations of scarcity by increasing their reinforcing value of snack food.

The effect of acute and chronic scarcity on acute stress: A dyadic developmental examination.

BACKGROUND: Food insecurity, obesity, and psychological stress are interrelated constructs which are thought to be connected through increased energy intake, but the underlying mechanisms for these relationships remain unclear. The current study used experimental methods to investigate how financial losses may influence acute stress in the context of food insecurity for both parents and offspring. This study also sought to examine the effect of acute stress related to financial losses on the reinforcing value of food (RRVfood) and delay discounting (DD). METHODS: One hundred and six families stratified by both offspring age (53 children aged 7-10, 53 adolescents aged 15-17) and household financial resources, visited our laboratory for three separate appointments. Each appointment included the experimental manipulation of financial gains and losses, saliva samples for cortisol assay, continuous heart rate monitoring, self-rated tension, and computer-based DD and RRVfood tasks. Participants also completed surveys to report perceived life stress level and food insecurity status. RESULTS: Among all participants, financial losses were related to decreased heart rates and increased self-rated tension. Among parents reporting food insecurity, acute financial losses resulted in an increase in cortisol levels. Changes in cortisol, heart rate, and tension were not related to RRVfood or DD. CONCLUSION: Food insecure parents are sensitive to financial losses and respond with an increase in cortisol. However, we found no evidence for a relationship between cortisol and RRVfood or DD. This sensitivity to financial losses did not extend to children or adolescents.

The Effect of Financial Scarcity on Reinforcer Pathology: A Dyadic Developmental Examination.

This study investigated the effects of experimentally manipulated scarcity on the reinforcing value of food (RRVfood) and delay discounting (DD), which, together, create reinforcer pathology (RP) among parents and offspring. A stratified sample of 106 families (53 parent/child aged 7−10 dyads & 53 parent/adolescent aged 15−17 dyads) from high- and low-income households visited our laboratory for three appointments. Each appointment included an experimental manipulation of financial gains and losses and DD and RRV tasks. The results showed that, regardless of food insecurity or condition, children had greater RP (ß = 1.63, p < 0.001) than adolescents and parents. DD was largely unaffected by acute scarcity in any group, but families with food insecurity had greater DD (ß = −0.09, p = 0.002) than food-secure families. Food-insecure parents with children responded to financial losses with an increase in their RRVfood (ß = −0.03, p = 0.011), while food-secure parents and food-insecure parents of adolescents did not significantly change their responding based on conditions. This study replicates findings that financial losses increase the RRVfood among adults with food insecurity and extends this literature by suggesting that this is strongest for parents of children.

Alcohol mixed energy drink usage and risk-taking among college students in Western New York State.

Alcohol mixed energy drinks (AmED) may promote excessive alcohol intake and risk-taking among college students. Objective: To understand the relationship between AmED use and risky behavior as well as attitudes and motivations for AmED use. Participants: Undergraduate college students N = 422 (Study 1), N = 37 (Study 2). Methods: Using a mixed-methods approach, we first surveyed undergraduate students about their AmED and alcohol consumption and a series of risk behaviors, self-efficacy, and beliefs (Study 1). We then conducted focus groups within the same population to better understand attitudes, knowledge, and motivations for using AmED (Study 2). Results: Recent AmED use was significantly associated with an increased number of reported binge drinking occasions and self-reported driving while intoxicated events. Our qualitative data analyses revealed two major themes associated with AmED consumption: factors encouraging AmED use and decisions about driving while under the influence of alcohol. Conclusions: These findings add to the literature of beliefs and motivations for AmED use among college students.

The effect of repeated episodic future thinking on the relative reinforcing value of snack food.

Obesity is related to delay discounting and relative reinforcing value of food. Episodic future thinking reduces delay discounting after one engagement. The effects of repeated engagement in episodic future thinking are unknown. We explored the effects of daily episodic future thinking on delay discounting, energy intake, and relative reinforcing value of food. Participants completed a delay discounting task, ad libitum buffet, and relative reinforcing value task following one engagement in episodic future thinking/episodic recent thinking and again after 1 week. One week of daily episodic future thinking did not reduce delay discounting compared to one engagement or episodic recent thinking. Engaging in episodic future thinking daily does not impact delay discounting, relative reinforcing value of snack food, or ad lib energy intake compared to one engagement in episodic future thinking.

The Effects of Messages about the Causes of Obesity on Disciplinary Action Decisions for Overweight Employees.

We investigated the impact of messages about the causes of obesity (controllable or uncontrollable) on the disciplinary action consequences selected for obese employees in response to a work-related mistake. Participants read about either the controllable or uncontrollable causes of obesity before reviewing an ostensible employee file that included a description of an employee mistake. Depending on condition, the file contained a photo of the employee that either depicted them as obese or average weight. Participants were more willing to withhold a raise or promotion from an obese employee than from an average-weight employee. Further, there was little evidence that the messages about the causes of obesity affected participants' perceived control and self-efficacy for healthy behaviors.

Reinforcing Value of Caffeinated and Noncaffeinated Beverages After Acute Exposure in Children and Adolescents.

Background: When caffeine is added to beverages, it increases beverage liking and the relative reinforcing value (RRV) of these beverages after repeated exposure. The purpose of this study was to test the hypothesis that a single acute exposure to caffeine increases liking and motivation to consume sugar-sweetened beverages (SSBs) relative to placebo. Methods: Participants were children ages 8-9 years (n = 36) and adolescents ages 15-17 years (n = 41) with an approximately equal number of boys and girls. A double-blind, placebo-controlled crossover study was conducted where participants sampled a SSB containing caffeine (1 and 2 mg/kg) on one visit and placebo (quinine 0.01 and 0.02 mg/kg) on a second visit day and then, on a third visit, played a computer game to earn points for the beverages and rated liking and taste sensations. They returned to the laboratory after a 1-week washout and had the alternate dose combination. Results: Acute exposure to the higher dose of caffeine increased the RRV of the SSB relative to placebo, but only when that dose was presented in the first week and only in female participants. The liking of the caffeine-containing SSB at the higher dose was lower than the placebo at all time points. Conclusions: These data suggest that a single exposure to a caffeinated SSB can impact its RRV and liking, but only under certain conditions and only in females. This supports previous work suggesting that caffeine can increase desire to consume SSB.

Daily exposure to either a high- or low-energy-dense snack food reduces its reinforcing value in adolescents.

OBJECTIVE: To examine the impact of daily exposure to a low-energy-dense (LED) or a high-energy-dense (HED) snack food on its reinforcing value (RRV) in adolescents with healthy weight, overweight, or obesity. METHODS: A parallel-group, randomized trial was used to assess RRV of LED or HED snack food at baseline and again after exposure to that snack food daily for 2 weeks in 77 adolescents, aged 13 to 17 years. Information on eating-related subject characteristics was also collected at baseline. RESULTS: After 2 weeks of daily exposure, the RRV of the snack foods was significantly reduced in all participants, regardless of energy density or participant weight status. Among individuals who were high in dietary restraint only, those randomized to LED food found their snack food less reinforcing at baseline than those who were randomized to HED food. Baseline eating-related variables also differed as a function of weight status. CONCLUSIONS: Daily exposure to snack food in adolescents reduces the RRV of that food regardless of snack food energy density or weight status of the adolescent. This finding differs from adults, suggesting that increases in RRV of HED food after repeated exposure may develop after adolescence.