Detalhe da pesquisa
1.
Exploring modular allostery via interchangeable regulatory domains.
Proc Natl Acad Sci U S A
; 115(12): 3006-3011, 2018 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507215
2.
Structure-function analyses of two plant meso-diaminopimelate decarboxylase isoforms reveal that active-site gating provides stereochemical control.
J Biol Chem
; 294(21): 8505-8515, 2019 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962284
3.
First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.
Proc Natl Acad Sci U S A
; 113(9): 2394-9, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26884182
4.
Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain.
Proc Natl Acad Sci U S A
; 110(6): 2111-6, 2013 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23345433
5.
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - The importance of accommodating the active site water.
Bioorg Chem
; 57: 242-250, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25245459
6.
Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.
J Biol Chem
; 286(12): 10216-24, 2011 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21282100
7.
A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals.
Front Mol Biosci
; 5: 29, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29682508
8.
The Functional Unit of Neisseria meningitidis 3-Deoxy-á´ -Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.
PLoS One
; 11(2): e0145187, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26828675
9.
Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism.
Curr Opin Struct Biol
; 29: 102-11, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25543886
10.
Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.
FEBS Lett
; 587(18): 3063-8, 2013 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916814
11.
Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
Protein Sci
; 22(8): 1087-99, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754471
12.
Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.
J Mol Biol
; 415(4): 716-26, 2012 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22154807