Detalhe da pesquisa
1.
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.
Cell
; 153(2): 389-401, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23582328
2.
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Cell
; 148(5): 1001-14, 2012 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22385964
3.
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage.
Cell
; 158(6): 1444, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28915370
4.
MYC determines lineage commitment in KRAS-driven primary liver cancer development.
J Hepatol
; 79(1): 141-149, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36906109
5.
Exploiting lipotoxicity for the treatment of liver cancer.
Br J Cancer
; 125(11): 1459-1461, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34302061
6.
Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC).
Mol Cell Proteomics
; 17(4): 810-825, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29363612
7.
Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling.
PLoS Comput Biol
; 14(9): e1006458, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30199525
8.
Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
Am J Pathol
; 187(2): 228-235, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27939741
9.
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models.
Gastroenterology
; 151(6): 1192-1205, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27614046
10.
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Nature
; 479(7374): 547-51, 2011 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22080947
11.
Optimized Target Residence Time: Typeâ I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Angew Chem Int Ed Engl
; 56(19): 5363-5367, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28397331
12.
Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.
Hepatology
; 60(3): 884-95, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799195
13.
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles.
J Med Chem
; 67(8): 6549-6569, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38604131
14.
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
J Med Chem
; 66(11): 7304-7330, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37226670
15.
HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1.
Cancers (Basel)
; 14(2)2022 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35053620
16.
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Nat Cancer
; 2(2): 201-217, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35122079
17.
Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Eur J Med Chem
; 208: 112721, 2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035818
18.
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.
Nat Commun
; 11(1): 1335, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32165639
19.
Nucleoporin Nup155 is part of the p53 network in liver cancer.
Nat Commun
; 10(1): 2147, 2019 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31089132
20.
Cardiac glycosides are broad-spectrum senolytics.
Nat Metab
; 1(11): 1074-1088, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31799499