Effects of Experiencing CS-US Pairings on Instructed Fear Reversal.

Fear learning allows us to identify and anticipate aversive events and adapt our behavior accordingly. This is often thought to rely on associative learning mechanisms where an initially neutral conditioned stimulus (CS) is repeatedly paired with an aversive unconditioned stimulus (US), eventually leading to the CS also being perceived as aversive and threatening. Importantly, however, humans also show verbal fear learning. Namely, they have the ability to change their responses to stimuli rapidly through verbal instructions about CS-US pairings. Past research on the link between experience-based and verbal fear learning indicated that verbal instructions about a reversal of CS-US pairings can fully override the effects of previously experienced CS-US pairings, as measured through fear ratings, skin conductance, and fear-potentiated startle. However, it remains an open question whether such instructions can also annul learned CS representations in the brain. Here, we used a fear reversal paradigm (female and male participants) in conjunction with representational similarity analysis of fMRI data to test whether verbal instructions fully override the effects of experienced CS-US pairings in fear-related brain regions or not. Previous research suggests that only the right amygdala should show lingering representations of previously experienced threat ("pavlovian trace"). Unexpectedly, we found evidence for the residual effect of prior CS-US experience to be much more widespread than anticipated, in the amygdala but also cortical regions like the dorsal anterior cingulate or dorsolateral prefrontal cortex. This finding shines a new light on the interaction of different fear learning mechanisms, at times with unexpected consequences.SIGNIFICANCE STATEMENT Humans are able to learn about aversive stimuli both from experience (i.e., repeated pairings of conditioned stimulus (CS) and unconditioned stimulus (US; pavlovian conditioning), and from verbal instructions about stimulus pairings. Understanding how experience-based and verbal learning processes interact is key for understanding the cognitive and neural underpinnings of fear learning. We tested whether prior aversive experiences (CS-US pairings) affected subsequent verbal learning, searching for lingering threat signals after verbal instructions reversed a CS from being threatening to being safe. While past research suggested such threat signals can only be found in the amygdala, we found evidence to be much more widespread, including the medial and lateral PFC. This highlights how experience-based and verbal learning processes interact to support adaptive behavior.

Thinking of learning phenomena as instances of relational behavior.

We explore the idea that some learning phenomena can be thought of as instances of relational behavior-more specifically, arbitrarily applicable relational responding (AARR). After explaining the nature of AARR, we discuss what it means to say that learning phenomena such as evaluative and fear conditioning are instances of AARR. We then list several implications of this perspective for empirical and theoretical research on learning, as well as for how learning phenomena relate to other psychological phenomena in human and nonhuman animals.

Putting relating at the core of language-of-thought.

Propositional representations are units of information with a relational content. Their relational nature allows for the six distinctive properties of language-of-thought representations. Putting relating at the core of language-of-thought also fits well with the idea that thinking and reasoning are instances of relational behavior. These propositional and behavioral perspectives can be combined within a functional-cognitive framework.

What is intuiting and deliberating? A functional-cognitive perspective.

We applaud De Neys for drawing attention to the interaction between intuiting and deliberating without committing to single- or dual process models. It remains unclear, however, how he conceptualizes the distinction between intuiting and deliberating. We propose several levels at which the distinction can be made and discuss the merits of defining intuiting and deliberating as different types of behavior.

Learned helplessness and its relevance for psychological suffering: a new perspective illustrated with attachment problems, burn-out, and fatigue complaints.

We develop a new perspective on various forms of psychological suffering - including attachment issues, burn-out, and fatigue complaints - by drawing on the construct of learned helplessness. We conceptualise learned helplessness in operant terms as the behavioural effects of a lack of reinforcement and in goal-directed terms as the dysregulation of goal-directed behaviour. Our central claim is that if one fails to reach a goal (e.g. the goal to secure a job), then not only this goal but also other related goals (e.g. the goal to maintain social relationships) may lose their motivating effects. The similarity relation between goal stimuli can therefore shed light on how failure in one life domain can come to affect various other life domains. We detail the relation between our proposal and existing theories and discuss new research and clinical directions.

Incidental Attitude Formation via the Surveillance Task: A Preregistered Replication of the Olson and Fazio (2001) Study.

Evaluative conditioning is one of the most widely studied procedures for establishing and changing attitudes. The surveillance task is a highly cited evaluative-conditioning paradigm and one that is claimed to generate attitudes without awareness. The potential for evaluative-conditioning effects to occur without awareness continues to fuel conceptual, theoretical, and applied developments. Yet few published studies have used this task, and most are characterized by small samples and small effect sizes. We conducted a high-powered (N = 1,478 adult participants), preregistered close replication of the original surveillance-task study (Olson & Fazio, 2001). We obtained evidence for a small evaluative-conditioning effect when "aware" participants were excluded using the original criterion-therefore replicating the original effect. However, no such effect emerged when three other awareness criteria were used. We suggest that there is a need for caution when using evidence from the surveillance-task effect to make theoretical and practical claims about "unaware" evaluative-conditioning effects.

The impact of valenced verbal information on implicit and explicit evaluation: the role of information diagnosticity, primacy, and memory cueing.

Previous research has shown that the presentation of valenced information about a target stimulus sometimes has different effects on implicit and explicit stimulus evaluations. Importantly, however, research examining the moderators of implicit-explicit dissociations has often failed to account for differences in the properties of the instruments used to measure implicit and explicit evaluations, preventing a clear interpretation of the results. In an effort to overcome these limitations, we conducted a study that probed the impact of valenced information on implicit and explicit evaluations as measured with procedures that were matched on methodological factors. Participants first read positive and negative information about a person named Bob and then completed measures of implicit and explicit evaluations of Bob. We examined the moderating effect of three characteristics: information diagnosticity, primacy, and whether information retrieval was cued during evaluation. Results of two high-powered experiments showed an effect of diagnosticity on implicit and explicit evaluations, replicating previous work, and extending it to new evaluation measures. We observed primacy effects on explicit evaluations in Experiment 1 and on implicit evaluations in Experiment 2. However, we did not observe memory cueing effects or any interactions. We discuss practical implications as well as implications for cognitive evaluation theories.

The impact of instruction- and experience-based evaluative learning on IAT performance: a Quad model perspective.

Learning procedures such as mere exposure, evaluative conditioning, and approach/avoidance training have been used to establish evaluative responses as measured by the Implicit Association Test (IAT). In this paper, we used the Quad model to disentangle the processes driving IAT responses instantiated by these evaluative learning procedures. Half of the participants experienced one of these three procedures whereas the other half only received instructions about how the procedure would work. Across three experiments (total n = 4231), we examined the extent to which instruction-based versus experience-based evaluative learning impacted Quad estimates of the Activation of evaluative information in IAT responses. Relative to a control condition, both instruction- and experience-based evaluative learning procedures influenced Activation. Moreover, and contrary to what prevailing models of implicit evaluations would predict, in no instance did experience-based procedures influence (positive or negative) Activation more strongly than instruction-based procedures. This was true for analyses which combined procedures and also when testing all three procedures individually. Implications for the processes that mediate evaluative learning effects and the conditions under which those processes operate are discussed.

Hypnotic Suggestions Can Induce Rapid Change in Implicit Attitudes.

We sometimes evaluate our environment (e.g., persons, objects, situations) in an automatic fashion. These automatic or implicit evaluations are often considered to be based on qualitatively distinct mental processes compared with more controlled or explicit evaluations. Important evidence for this claim comes from studies showing that implicit evaluations do not change as the result of counterattitudinal information, in contrast to their explicit counterparts. We examined the impact of counterattitudinal information on implicit evaluations in two experiments (N = 60, N = 72) that included an innovative manipulation: hypnotic suggestions to participants that they would strongly process upcoming counterattitudinal information. Both experiments indicated that hypnotic suggestions facilitated effects of counterattitudinal information on implicit evaluations. These findings extend recent evidence for rapid revision of implicit evaluations on the basis of counterattitudinal information and support the controversial idea that belief-based processes underlie not only explicit but also implicit evaluations.

How Do Actions Influence Attitudes? An Inferential Account of the Impact of Action Performance on Stimulus Evaluation.

Over the past decade, an increasing number of studies have shown that the performance of specific actions (e.g., approach and avoidance) in response to a stimulus can lead to changes in how that stimulus is evaluated. In contrast to the reigning idea that these effects are mediated by the automatic formation and activation of associations in memory, we describe an inferential account that specifies the inferences underlying the effects and how these inferences are formed. We draw on predictive processing theories to explain the basic processes underlying inferential reasoning and their main characteristics. Our inferential account accommodates past findings, is supported by new findings, and leads to novel predictions as well as concrete recommendations for how action performance can be used to influence real-world behavior.

Toward a cumulative science of emotion: a functional-cognitive framework for emotion research.

Definitions of emotion and emotional phenomena are often infused with intuitions and theoretical ideas about what is "truly" emotional. Although these intuitions and ideas motivate people to study emotion, their prominence at the conceptual level can hamper progress in emotion research. In this paper, we argue that there is merit in defining emotional phenomena as much as possible in terms of behavioural principles that have been developed outside of emotion research. We clarify that such a functional approach is compatible with, and can even strengthen, cognitive approaches to emotion research. This functional-cognitive perspective reveals ways to increase the cumulative nature of emotion research and to surpass initial intuitions and theoretical ideas.

Evaluative conditioning effects are modulated by the nature of contextual pairings.

Across two studies participants completed a learning phase comprised of two types of trials: context pairing trials in which two (valenced or non-valenced) words were identical or opposite to one another and evaluative conditioning (EC) trials in which a CS was paired with a US. Based on the idea that EC occurs because CS-US pairings function as a symbolic cue about the relation between the CS and the US, we hypothesised that the nature of context pairings (identical or opposite) might moderate EC effects. Results indicate that identity-based context pairs led to typical assimilative explicit and implicit effects whereas opposition-based pairs led to attenuated effects. Implications and different accounts of our findings are discussed.

Pattern Analyses Reveal Separate Experience-Based Fear Memories in the Human Right Amygdala.

Learning fear via the experience of contingencies between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) is often assumed to be fundamentally different from learning fear via instructions. An open question is whether fear-related brain areas respond differently to experienced CS-US contingencies than to merely instructed CS-US contingencies. Here, we contrasted two experimental conditions where subjects were instructed to expect the same CS-US contingencies while only one condition was characterized by prior experience with the CS-US contingency. Using multivoxel pattern analysis of fMRI data, we found CS-related neural activation patterns in the right amygdala (but not in other fear-related regions) that dissociated between whether a CS-US contingency had been instructed and experienced versus merely instructed. A second experiment further corroborated this finding by showing a category-independent neural response to instructed and experienced, but not merely instructed, CS presentations in the human right amygdala. Together, these findings are in line with previous studies showing that verbal fear instructions have a strong impact on both brain and behavior. However, even in the face of fear instructions, the human right amygdala still shows a separable neural pattern response to experience-based fear contingencies.SIGNIFICANCE STATEMENT In our study, we addressed a fundamental problem of the science of human fear learning and memory, namely whether fear learning via experience in humans relies on a neural pathway that can be separated from fear learning via verbal information. Using two new procedures and recent advances in the analysis of brain imaging data, we localized purely experience-based fear processing and memory in the right amygdala, thereby making a direct link between human and animal research.

Encoding of Novel Verbal Instructions for Prospective Action in the Lateral Prefrontal Cortex: Evidence from Univariate and Multivariate Functional Magnetic Resonance Imaging Analysis.

Verbal instructions are central to humans' capacity to learn new behaviors with minimal training, but the neurocognitive mechanisms involved in verbally instructed behaviors remain puzzling. Recent functional magnetic resonance imaging (fMRI) evidence suggests that the right middle frontal gyrus and dorsal premotor cortex (rMFG-dPMC) supports the translation of symbolic stimulus-response mappings into sensorimotor representations. Here, we set out to (1) replicate this finding, (2) investigate whether this region's involvement is specific to novel (vs. trained) instructions, and (3) study whether rMFG-dPMC also shows differences in its (voxel) pattern response indicative of general cognitive processes of instruction implementation. Participants were shown instructions, which they either had to perform later or merely memorize. Orthogonal to this manipulation, the instructions were either entirely novel or had been trained before the fMRI session. Results replicate higher rMFG-dPMC activation levels during instruction implementation versus memorization and show how this difference is restricted to novel, but not trained, instruction presentations. Pattern similarity analyses at the voxel level further reveal more consistent neural pattern responses in rMFG-dPMC during the implementation of novel versus trained instructions. In fact, this more consistent neural pattern response seemed to be specific to the first instruction presentation and disappeared after the instruction had been applied once. These results further support a role of rMFG-dPMC in the implementation of novel task instructions and highlight potentially important differences in studying this region's gross activation levels versus (the consistency of) its response patterns.

Consequence-Based Approach-Avoidance Training: A New and Improved Method for Changing Behavior.

The repeated performance of approach or avoidance actions in response to specific stimuli (e.g., alcoholic drinks) is often considered a most promising type of cognitive-bias modification that can reduce unwanted behavior (e.g., alcohol consumption). Unfortunately, approach-avoidance training sometimes fails to produce desired outcomes (e.g., in the context of unhealthy eating). We introduce a novel training task in which approach-avoidance actions are followed by affective consequences. Four experiments (total N = 1,547) found stronger changes in voluntary approach-avoidance behavior, implicit and explicit evaluations, and consumer choices for consequence-based approach-avoidance training in the food domain. Moreover, this novel type of training reduced self-reported unhealthy eating behavior after a 24-hr delay and unhealthy snacking in a taste test. Our results contrast with dominant (association-formation) accounts of the effects of approach-avoidance training and support an inferential explanation. They further suggest that consequence-based approach-avoidance training, and inference training more generally, holds promise for the treatment of clinical behavior.

Placebo Effects of Open-label Verbal Suggestions on Itch.

Placebo effects are positive outcomes that are not due to active treatment components, which may be elicited even when patients are aware of receiving an inert substance (open-label). This proof-of-principle study investigated for the first time whether open-label placebo effects on itch can be induced by verbal suggestions alone. Ninety-two healthy volunteers were randomized to experimental (open-label suggestions) or control (no suggestions) groups. Self-reported itch evoked by histamine iontophoresis was the primary study outcome. In addition, itch expectations, skin condition and affect were assessed. The experimental group expected lower itch than the control group, which was, in turn, related to less experienced itch in this group only, although no significantly different itch levels were reported between groups. The results illustrate a potential role for open-label placebo effects in itch, and suggest that further study of verbal suggestions through an extensive explanation of placebo effects might be promising for clinical practice.

The contextual malleability of approach-avoidance training effects: approaching or avoiding fear conditioned stimuli modulates effects of approach-avoidance training.

Previous research showed that the repeated approaching of one stimulus and avoiding of another stimulus typically leads to more positive evaluations of the former stimuli. In the current study, we examined whether approach and avoidance training (AAT) effects on evaluations of neutral stimuli can be modulated by introducing a regularity between the approach-avoidance actions and a positive or negative (feared) stimulus. In an AAT task, participants repeatedly approached one neutral non-word and avoided another neutral non-word. Half of the participants also approached a negative fear-conditioned stimulus (CS+) and avoided a conditioned safe stimulus (CS-). The other half of the participants avoided the CS+ and approached the CS-. Whereas participants in the avoid CS+ condition exhibited a typical AAT effect, participants in the approach CS+ condition exhibited a reversed AAT effect (i.e. they evaluated the approached neutral non-word as more negative than the avoided non-word). These findings provide evidence for the malleability of the AAT effect when strongly valenced stimuli are approached or avoided. We discuss the practical and theoretical implications of our findings.

Body Dissatisfaction Revisited: On the Importance of Implicit Beliefs about Actual and Ideal Body Image.

Body dissatisfaction (i.e., a negative attitude towards one's own physical appearance) is assumed to originate from a perceived discrepancy between the actual physical appearance (i.e., actual body image) and the desired ideal state of the body (i.e., ideal body image). We assessed implicit beliefs about these two aspects of the body image independently using two Relational Responding Tasks (RRT) in a sample of participants who were either low or high in explicitly reported body dissatisfaction. As hypothesized, differences in body dissatisfaction exerted a differential influence on the two RRT scores. The implicit belief that one is thin was less pronounced in participants who were strongly dissatisfied with their body relative to participants who were more satisfied with their body. The implicit desire to be thin (i.e., thin ideal body image), in contrast, tended to be more pronounced in participants who exhibited a high degree of body dissatisfaction as compared to participants who exhibited a low degree of body dissatisfaction. Hierarchical regression analyses also revealed that the RRT scores were predictive of self-reported body dissatisfaction, even over and above the predictive validity of some (but not all) explicit predictors of body dissatisfaction that were included in the present study. More generally, these findings contribute to the empirical validation of the RRT as a measure of implicit beliefs in the context of body dissatisfaction.

Paul Eelen: Reflections on Life and Work.

This manuscript is part of a special issue to commemorate professor Paul Eelen, who passed away on August 21, 2016. Paul was a clinically oriented scientist, for whom learning principles (Pavlovian or operant) were more than salivary responses and lever presses. His expertise in learning psychology and his enthusiasm to translate this knowledge to clinical practice inspired many inside and outside academia. Several of his original writings were in the Dutch language. Instead of editing a special issue with contributions of colleagues and friends, we decided to translate a selection of his manuscripts to English to allow wide access to his original insights and opinions. Even though the manuscripts were written more than two decades ago, their content is surprisingly contemporary. This introductory article presents a reflection on Paul's career and legacy and introduces the selected manuscripts that are part of this special issue.

The Actual and Ideal Sexual Self Concept in the Context of Genital Pain Using Implicit and Explicit Measures.

BACKGROUND: The experience of pain during sexual intercourse generates significant distress and sexual impairments, which is likely to affect sexual identity and become a threat to the sense of self. AIM: To explore the role of the concept of the sexual self in the context of genital pain by measuring different states of self (ie, actual vs ideal) at different levels of responding (ie, explicit vs implicit) and examine their associations with sexual, emotional, and pain-related variables. METHODS AND MAIN OUTCOMES: Thirty young women who identified with genital pain and 29 women without pain completed (i) two versions of the Relational Responding Task as a measurement of implicit actual and ideal sexual self; (ii) explicit ratings of the actual and the ideal sexual self; and (iii) measurements of sexual self-esteem, global self-esteem, depression, sexual satisfaction, sexual distress or depression, sexual frequency, and pain experiences. RESULTS: Women with genital pain scored lower on the explicit and implicit actual-self measurements than women without pain but did not differ in their ideal self. Furthermore, the pain group reported higher ideal- than actual-self scores at the explicit level. Actual- and ideal-self measurements had differential effects on sexual, emotional, and behavioral outcome variables. In general, rating the ideal self higher than the actual self was related to more negative outcomes. Pain-related variables were predicted only by the implicit measurements, showing that the high pain group reported more pain, fear of pain, and a stronger tendency to continue with sex despite the pain when perceiving themselves as sexually less competent and when this perception did not match their ideal self. CLINICAL IMPLICATIONS: Therapeutic interventions might benefit from discussing women's internal guides for self, decreasing potential discrepancies, and developing identity-related motivational treatments that target the emotional discomfort and maladaptive behavioral strategies that result from trying to conform with their guides of self. Setting idealistically high sexual standards, feeling pressure to perform as a sexual partner, and fearing to be sexually unqualified could be key factors in developing, maintaining, and exacerbating sexual dysfunctions. STRENGTHS AND LIMITATIONS: This is the first study to systematically examine different components of the concept of the sexual self in the context of genital pain. Despite the small sample and the use of a non-clinical group of women, we found a theoretically and clinically interesting pattern of results. CONCLUSIONS: Differentiating between different components of the sexual self is relevant to explain sexual, emotional, and pain-related responses. Dewitte M, De Schryver M, Heider N, De Houwer J. The Actual and Ideal Sexual Self Concept in the Context of Genital Pain Using Implicit and Explicit Measures. J Sex Med 2017;14:702-714.