Detalhe da pesquisa
1.
Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer.
Respir Res
; 24(1): 272, 2023 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37932762
2.
Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation.
Proc Natl Acad Sci U S A
; 116(15): 7308-7313, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902895
3.
Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV.
J Gen Virol
; 102(12)2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34904939
4.
Non-nucleoside Reverse Transcriptase Inhibitors Inhibit Reverse Transcriptase through a Mutually Exclusive Interaction with Divalent Cation-dNTP Complexes.
Biochemistry
; 58(16): 2176-2187, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30900874
5.
An Evolutionary/Biochemical Connection between Promoter- and Primer-Dependent Polymerases Revealed by Systematic Evolution of Ligands by Exponential Enrichment.
J Bacteriol
; 200(7)2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339418
6.
Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.
Biochemistry
; 56(1): 33-46, 2017 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27936595
7.
Selection of 2'-deoxy-2'-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity.
Nucleic Acids Res
; 43(20): 9587-99, 2015 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26476448
8.
Human immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.
J Virol
; 88(15): 8514-27, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24850729
9.
Alternative divalent cations (Zn²âº, Co²âº, and Mn²âº) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.
BMC Biochem
; 16: 12, 2015 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25934642
10.
Synthetic, structural mimetics of the ß-hairpin flap of HIV-1 protease inhibit enzyme function.
Bioorg Med Chem
; 23(21): 7095-109, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26474665
11.
Inhibition of SARS-CoV-2 Infection in Human Airway Epithelium with a Xeno-Nucleic Acid Aptamer.
bioRxiv
; 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37808754
12.
Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.
J Biol Chem
; 286(47): 40433-42, 2011 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953456
13.
Duplex structural differences and not 2'-hydroxyls explain the more stable binding of HIV-reverse transcriptase to RNA-DNA versus DNA-DNA.
Nucleic Acids Res
; 38(13): 4426-35, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20338878
14.
Selection of Primer-Template Sequences That Bind with Enhanced Affinity to Vaccinia Virus E9 DNA Polymerase.
Viruses
; 14(2)2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35215961
15.
Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX approaches.
Trends Biotechnol
; 40(5): 549-563, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34756455
16.
Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing.
Drug Discov Today
; 27(7): 1832-1846, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35218925
17.
Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation.
Sci Adv
; 8(27): eabn9874, 2022 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35857464
18.
A primer-free method that selects high-affinity single-stranded DNA aptamers using thermostable RNA ligase.
Anal Biochem
; 414(2): 246-53, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21420926
19.
HIV Reverse Transcriptase Pre-Steady-State Kinetic Analysis of Chain Terminators and Translocation Inhibitors Reveals Interactions between Magnesium and Nucleotide 3'-OH.
ACS Omega
; 6(22): 14621-14628, 2021 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34124485
20.
Xeno-Nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding.
Viruses
; 13(10)2021 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34696413