Detalhe da pesquisa
1.
Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome.
Mol Cell
; 75(3): 631-643.e8, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31279658
2.
Internal RNA 2'O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect.
Nucleic Acids Res
; 51(6): 2501-2515, 2023 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36354007
3.
5'-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2'-O-methyltransferases.
Bioorg Chem
; 143: 107035, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38199140
4.
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome.
Nucleic Acids Res
; 50(19): 11186-11198, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36265859
5.
Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus.
J Biol Chem
; 298(9): 102337, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35931116
6.
Access to High-Purity 7m G-cap RNA in Substantial Quantities by a Convenient All-Chemical Solid-Phase Method.
Chembiochem
; 24(22): e202300544, 2023 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37666794
7.
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation.
PLoS Pathog
; 17(5): e1009562, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33956914
8.
Reversible methylation of m6Am in the 5' cap controls mRNA stability.
Nature
; 541(7637): 371-375, 2017 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002401
9.
First insights into the structural features of Ebola virus methyltransferase activities.
Nucleic Acids Res
; 49(3): 1737-1748, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33503246
10.
Facile access to 4'-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14.
Org Biomol Chem
; 20(38): 7582-7586, 2022 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36156055
11.
The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation.
J Virol
; 94(12)2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32269120
12.
FTO controls reversible m6Am RNA methylation during snRNA biogenesis.
Nat Chem Biol
; 15(4): 340-347, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30778204
13.
La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.
Nucleic Acids Res
; 46(3): 1457-1469, 2018 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29244122
14.
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.
Nucleic Acids Res
; 46(15): 7902-7912, 2018 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30192980
15.
Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers.
Molecules
; 25(11)2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32545345
16.
Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5' Caps.
Chembiochem
; 20(13): 1693-1700, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30768827
17.
Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.
J Virol
; 91(5)2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28031370
18.
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
J Virol
; 91(5)2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28031359
19.
A 2',2'-disulfide-bridged dinucleotide conformationally locks RNA hairpins.
Org Biomol Chem
; 16(17): 3181-3188, 2018 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29645048
20.
Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2'-position.
Bioorg Med Chem
; 26(16): 4635-4643, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30121212