Detalhe da pesquisa
1.
Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents.
Bioorg Med Chem
; 101: 117645, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401456
2.
2-Methoxyestradiol-3,17-O,O-bis-sulfamate (STX140) Inhibits Proliferation and Invasion via Senescence Pathway Induction in Human BRAFi-Resistant Melanoma Cells.
Int J Mol Sci
; 24(14)2023 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37511073
3.
Synthesis and In Vitro Antimicrobial SAR of Benzyl and Phenyl Guanidine and Aminoguanidine Hydrazone Derivatives.
Molecules
; 28(1)2022 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615201
4.
Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451.
Molecules
; 27(12)2022 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35744942
5.
Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.
Br J Cancer
; 113(8): 1158-67, 2015 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26461061
6.
Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations.
Antibiotics (Basel)
; 12(3)2023 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36978428
7.
2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.
Biochim Biophys Acta Mol Cell Res
; 1870(6): 119485, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37150482
8.
Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin.
Eur J Pharmacol
; 960: 176119, 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37852569
9.
2-Difluoromethoxy-Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition.
ChemMedChem
; 17(23): e202200408, 2022 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36109340
10.
2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: Identification of a new and potent inhibitor.
Biochim Biophys Acta Mol Cell Res
; 1868(6): 118988, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33581218
11.
Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors.
ACS Omega
; 5(44): 28793-28811, 2020 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33195933
12.
3,17ß-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
J Med Chem
; 62(4): 2202-2212, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30721041
13.
Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.
ACS Omega
; 4(1): 755-764, 2019 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30775645
14.
A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic.
Chem Sci
; 10(20): 5382-5390, 2019 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31171961
15.
Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2).
BMC Pharmacol Toxicol
; 20(1): 67, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31730023
16.
A protecting group free synthesis of (+/-)-neostenine via the [5 + 2] photocycloaddition of maleimides.
J Org Chem
; 73(17): 6497-505, 2008 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18656978
17.
Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines.
Drug Des Devel Ther
; 12: 1881-1904, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29983544
18.
Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.
J Med Chem
; 61(3): 1031-1044, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227648
19.
Highly functionalized organomagnesium reagents prepared through halogen-metal exchange.
Angew Chem Int Ed Engl
; 42(36): 4302-20, 2003 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-14502700
20.
Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds.
Org Lett
; 4(11): 1819-22, 2002 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12027622